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Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor

Xiao-Yan Zhao
Peter J. Malloy
David Feldman
Research01 Jun 2000
Nature Medicine

Volume: 6, P: 703-706
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment

Giafaglione et al. define metabolic regulation of prostate epithelial lineage identity and show that modulation of lactate metabolism alters response to antiandrogen therapy.

Jenna M. Giafaglione
Preston D. Crowell
Andrew S. Goldstein
ResearchOpen Access04 Dec 2023
Nature Cell Biology

Volume: 25, P: 1821-1832
The future of patient-derived xenografts in prostate cancer research

This Perspective covers existing patient-derived xenografts (PDXs) of prostate cancer, and their features and uses in basic and preclinical research. The authors also discuss the need for additional PDXs, and how collaboration in prostate cancer PDX research can be improved.

Mitchell G. Lawrence
Renea A. Taylor
Gail P. Risbridger
Reviews17 Jan 2023
Nature Reviews Urology

Volume: 20, P: 371-384
Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer

The gene CHD1 is synthetic essential in PTEN-deficient prostate and breast cancers.

Di Zhao
Xin Lu
Ronald A. DePinho
Research06 Feb 2017
Nature

Volume: 542, P: 484-488
Autophagy inhibition by targeting PIKfyve potentiates response to immune checkpoint blockade in prostate cancer

Chinnaiyan and colleagues perform a high-throughput compound screen and identify PIKfyve inhibition as a therapeutic strategy to enhance immune checkpoint blockade responses in advanced prostate cancer.

Yuanyuan Qiao
Jae Eun Choi
Arul M. Chinnaiyan
Research02 Aug 2021
Nature Cancer

Volume: 2, P: 978-993
Author Correction: Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer

Lanbo Xiao
Abhijit Parolia
Arul M. Chinnaiyan
Amendments and CorrectionsOpen Access22 Apr 2024
Nature

Volume: 629, P: E9
Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer

PROTAC degrader–induced SWI/SNF inactivation abolishes DNA accessibility at enhancer elements of oncogenes and also tempers supra-physiologic expression of driver transcription factors, resulting in potent inhibition of tumour growth in mouse models.

Lanbo Xiao
Abhijit Parolia
Arul M. Chinnaiyan
ResearchOpen Access22 Dec 2021
Nature

Volume: 601, P: 434-439
Prostate cancer castrate resistant progression usage of non-canonical androgen receptor signaling and ketone body fuel

Estefania Labanca
Juan Bizzotto
Geraldine Gueron
ResearchOpen Access28 Sept 2021
Oncogene

Volume: 40, P: 6284-6298
Game-changing restraint of Ros-damaged phenylalanine, upon tumor metastasis

Geraldine Gueron
Nicolás Anselmino
Elba Vazquez
ResearchOpen Access02 Feb 2018
Cell Death & Disease

Volume: 9, P: 1-15
Optimizing the diagnosis and management of ductal prostate cancer

Ductal adenocarcinoma of the prostate is the most common variant histological subtype of prostate cancer. The diagnosis can be challenging and evidence for treatment is predominantly based on retrospective data. This Review discusses the histopathology, characteristics, treatment options and future molecular targets for treatment of this disease.

Weranja Ranasinghe
Daniel D. Shapiro
Brian F. Chapin
Reviews06 Apr 2021
Nature Reviews Urology

Volume: 18, P: 337-358
The expression of YWHAZ and NDRG1 predicts aggressive outcome in human prostate cancer

Using integrative tissue-omics, Lage-Vickers, Bizzotto et al. classify prostate cancer patients into high YWHAZ and NDRG1 expression subgroups that correlate with a high and intermediate risk of disease progression. This study identifies molecular biomarkers associated with aggressive prostate cancer.

Sofia Lage-Vickers
Juan Bizzotto
Geraldine Gueron
ResearchOpen Access22 Jan 2021
Communications Biology

Volume: 4, P: 1-13
Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition

Chao Wang
Gang Wang
Junjie Chen
Research07 Dec 2018
Oncogene

Volume: 38, P: 2451-2463
Oncogenic and osteolytic functions of histone demethylase NO66 in castration-resistant prostate cancer

Krishna M. Sinha
Rozita Bagheri-Yarmand
Johnny Huard
Research11 Mar 2019
Oncogene

Volume: 38, P: 5038-5049
Heme oxygenase-1 in the forefront of a multi-molecular network that governs cell–cell contacts and filopodia-induced zippering in prostate cancer

Alejandra V Paez
Carla Pallavicini
Geraldine Gueron
ResearchOpen Access29 Dec 2016
Cell Death & Disease

Volume: 7, P: e2570

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