Nature Search

Cleavage of the Meckel-Gruber syndrome protein TMEM67 by ADAMTS9 uncouples Wnt signaling and ciliogenesis

How Meckel-Gruber syndrome protein TMEM67 functions in ciliogenesis and Wnt signaling simultaneously is unknown. Here the authors show that TMEM67 is proteolytically cleaved by the matrix metalloproteinase ADAMTS9 generating two functional isoforms.

Manu Ahmed
Sydney Fischer
Sumeda Nandadasa
ResearchOpen Access28 May 2025
Nature Communications

Volume: 16, P: 1-20
Decline of kidney function is associated with lower sweat weight in patients with chronic kidney disease

Tarik Shoumariyeh
Florian Logar
Johannes J. Kovarik
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-8
No impairment of quality of life after radiotherapy for prostate cancer

Maria M. Meier
Oliver Koelbl
Isabella Gruber
ResearchOpen Access31 Dec 2024
Scientific Reports

Volume: 14, P: 1-8
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

Genome-wide association analyses of intracranial and nine subcortical brain volumes in 74,898 participants of European ancestry identify 254 independent loci and yield polygenic scores accounting for brain variation across ancestries.

Luis M. García-Marín
Adrian I. Campos
Miguel E. Rentería
Research21 Oct 2024
Nature Genetics

Volume: 56, P: 2333-2344
Revealing the ___location and dynamics of a concealed binding site in the dopamine transporter

The number of ligand binding sites in the dopamine transporter is enigmatic due to conflicting data from structures and molecular pharmacology. Here, force spectra reveal the position and dynamics of a previously invisible transient site.

Rong Zhu
Walter Sandtner
Peter Hinterdorfer
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-12
Aristotle's Physics

OLIVER LODGE
Research29 Jan 1914
Nature

Volume: 92, P: 606
Disturbed Anterior Prefrontal Control of the Mesolimbic Reward System and Increased Impulsivity in Bipolar Disorder

Sarah Trost
Esther Kristina Diekhof
Oliver Gruber
Research18 Feb 2014
Neuropsychopharmacology

Volume: 39, P: 1914-1923
Asymmetry, cytoarchitectonic morphology and genetics associated with Broca’s area in schizophrenia

In this paper, the authors present findings demonstrating that variations of the MET gene are associated with specific structural differences in key language regions in individuals with schizophrenia.

Saskia Zimmermann
Katrin Sakreida
Timm B. Poeppl
Research29 Jan 2024
Nature Mental Health

Volume: 2, P: 310-319
Genetic architecture of subcortical brain structures in 38,851 individuals

Genome-wide analysis identifies variants associated with the volume of seven different subcortical brain regions defined by magnetic resonance imaging. Implicated genes are involved in neurodevelopmental and synaptic signaling pathways.

Claudia L. Satizabal
Hieab H. H. Adams
M. Arfan Ikram
Research21 Oct 2019
Nature Genetics

Volume: 51, P: 1624-1636
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Barbara Franke
Jason L Stein
Patrick F Sullivan
Research01 Feb 2016
Nature Neuroscience

Volume: 19, P: 420-431
Novel genetic loci associated with hippocampal volume

The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.

Derrek P. Hibar
Hieab H. H. Adams
M. Arfan Ikram
ResearchOpen Access18 Jan 2017
Nature Communications

Volume: 8, P: 1-12
Novel genetic loci underlying human intracranial volume identified through genome-wide association

In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cognitive function and to Parkinson's disease, and enriched near genes involved in growth pathways, including PI3K-AKT signaling.

Hieab H H Adams
Derrek P Hibar
Paul M Thompson
Research03 Oct 2016
Nature Neuroscience

Volume: 19, P: 1569-1582
Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis

Jan Pencik
Michaela Schlederer
Lukas Kenner
Amendments and CorrectionsOpen Access26 Oct 2015
Nature Communications

Volume: 6, P: 1
Investigating the Impact of a Genome-Wide Supported Bipolar Risk Variant of MAD1L1 on the Human Reward System

Sarah Trost
Esther K Diekhof
Oliver Gruber
Research13 May 2016
Neuropsychopharmacology

Volume: 41, P: 2679-2687
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

Mutations in proteins that localize to primary cilia cause devastating diseases, yet the primary cilium is a poorly understood organelle. Here the authors use interaction proteomics to identify a network of human ciliary proteins that provides new insights into several biological processes and diseases.

Karsten Boldt
Jeroen van Reeuwijk
Kathy Williamson
ResearchOpen Access13 May 2016
Nature Communications

Volume: 7, P: 1-13
PSYSCAN multi-centre study: baseline characteristics and clinical outcomes of the clinical high risk for psychosis sample

Stefania Tognin
Sandra Vieira
Philip McGuire
ResearchOpen Access17 Apr 2025
Schizophrenia

Volume: 11, P: 1-9
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition

SARS-CoV-2-specific CD4⁺ and CD8⁺ T cell epitopes are found in both convalescent patients and virus-naive volunteers and are indicative of heterologous recognition shared with seasonal cold viruses.

Annika Nelde
Tatjana Bilich
Juliane S. Walz
Research30 Sept 2020
Nature Immunology

Volume: 22, P: 74-85
Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3′ UTRs

The RNA helicase UPF1 has been implicated in various functions including nonsense-mediated decay (NMD). Transcriptome-wide analysis of UPF1-binding sites in translationally active versus inhibited cells provides evidence for translation-independent UPF1-RNA interactions and also suggests that UPF1 bound to coding sequence may be displaced by translating ribosomes and that NMD substrate selection may occur after UPF1-RNA interaction.

David Zünd
Andreas R Gruber
Oliver Mühlemann
Research07 Jul 2013
Nature Structural & Molecular Biology

Volume: 20, P: 936-943
STAT3 regulated ARF expression suppresses prostate cancer metastasis

IL6-STAT3 signaling is activated in prostate cancer, however inhibiting this pathway has not lead to a survival advantage in patients. Here, Pencik et al.show that loss of the IL6-STAT3 axis in mice and humans leads to metastasis due to loss of ARF, unravelling STAT3 and ARF as potential prognostic markers in prostate cancer.

Jan Pencik
Michaela Schlederer
Lukas Kenner
ResearchOpen Access22 Jul 2015
Nature Communications

Volume: 6, P: 1-15
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

Edith Hofer
Gennady V. Roshchupkin
Sudha Seshadri
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Azimuthal C/O variations in a planet-forming disk

ALMA observations of the protoplanetary disk around HD 100546 reveal an unexpected C/O variation with azimuth. The carbon-dominated wedge of the disk can be reproduced via a model with a shadowing mechanism.

Luke Keyte
Mihkel Kama
Catherine Walsh
Research20 Apr 2023
Nature Astronomy

Volume: 7, P: 684-693
Transport and barrier mechanisms that regulate ciliary compartmentalization and ciliopathies

The compartmentalized structure of primary cilia is maintained via interconnected barrier and active transport systems and underlies its unique composition and function. This Review describes the major compartmentalizing pathways that occur at the cilium and how insights into cilia transport and barrier mechanisms have shed light on the mechanisms underlying ciliary diseases.

Ailis L. Moran
Laura Louzao-Martinez
Oliver E. Blacque
Reviews23 Oct 2023
Nature Reviews Nephrology

Volume: 20, P: 83-100
TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome

The ciliary transition zone (TZ) at the base of cilia is thought to gate entry of proteins into the cilium. The authors characterize a role for TMEM107, a protein mutated in the ciliopathy Joubert syndrome, in organizing a submodule of the TZ.

Nils J. Lambacher
Ange-Line Bruel
Oliver E. Blacque
Research23 Nov 2015
Nature Cell Biology

Volume: 18, P: 122-131
Common genetic variants influence human subcortical brain structures

Genome-wide association studies are used to identify common genetic variants that affect the structure of selected subcortical regions of the human brain; their identification provides insight into the causes of variability in brain development and may help to determine mechanisms of neuropsychiatric dysfunction.

Derrek P. Hibar
Jason L. Stein
Sarah E. Medland
Research21 Jan 2015
Nature

Volume: 520, P: 224-229
Thermophilic archaea activate butane via alkyl-coenzyme M formation

Anaerobic archaea enriched in thermophilic microbial consortia completely degrade butane by modifying mechanisms which were hitherto thought to be specific to methane metabolism.

Rafael Laso-Pérez
Gunter Wegener
Florin Musat
Research17 Oct 2016
Nature

Volume: 539, P: 396-401
Multivariable prediction of functional outcome after first-episode psychosis: a crossover validation approach in EUFEST and PSYSCAN

Margot I. E. Slot
Maria F. Urquijo Castro
René S. Kahn
ResearchOpen Access07 Oct 2024
Schizophrenia

Volume: 10, P: 1-11
Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study

Anna H. Ou
Sara B. Rosenthal
John R. Kelsoe
ResearchOpen Access23 Feb 2024
Translational Psychiatry

Volume: 14, P: 1-9
An eclipsing substellar binary in a young triple system discovered by SPECULOOS

2M1510 is an approximately 45-million-year-old triple system of brown dwarfs, two of which form a close binary in a 20-day orbit and have almost the same mass (3.82% and 3.75% of the mass of the Sun, respectively). Their physical parameters are in good agreement with evolutionary models except for luminosity, suggesting that we might be underestimating the masses of brown dwarfs and massive exoplanets by about 30%.

Amaury H. M. J. Triaud
Adam J. Burgasser
Michaël Gillon
Research09 Mar 2020
Nature Astronomy

Volume: 4, P: 650-657
Structural basis of oligomerization in the stalk region of dynamin-like MxA

Dynamin is a protein that catalyses the scission of clathrin-coated pits at the plasma membrane. The mechanisms of dynamin-catalysed scission remain poorly understood. Here, the structure of the stalk region of human MxA, a dynamin-like protein, is presented. A structural model of MxA oligomerization and stimulated GTP hydrolysis is put forward that has functional implications for all members of the dynamin family.

Song Gao
Alexander von der Malsburg
Oliver Daumke
Research28 Apr 2010
Nature

Volume: 465, P: 502-506
Genome-wide interaction study with major depression identifies novel variants associated with cognitive function

Anbupalam Thalamuthu
Natalie T. Mills
Bernhard T. Baune
Research15 Nov 2021
Molecular Psychiatry

Volume: 27, P: 1111-1119
Single-stranded RNA viruses infecting the invasive Argentine ant, Linepithema humile

Monica A. M. Gruber
Meghan Cooling
Philip J. Lester
ResearchOpen Access12 Jun 2017
Scientific Reports

Volume: 7, P: 1-10
An ultrahot Neptune in the Neptune desert

LTT 9779 b is Neptune-sized planet rotating around its star with a period of 0.79 days and an equilibrium temperature of 2,000 K. It is not clear how it retained its atmospheric envelope, which contains ~10% of H/He, as it should have been photoevaporated by now.

James S. Jenkins
Matías R. Díaz
Andrew W. Mann
Research14 Sept 2020
Nature Astronomy

Volume: 4, P: 1148-1157
The International Climate Psychology Collaboration: Climate change-related data collected from 63 countries

Kimberly C. Doell
Boryana Todorova
Jay J. Van Bavel
ResearchOpen Access01 Oct 2024
Scientific Data

Volume: 11, P: 1-17
Enhanced production of multi-strange hadrons in high-multiplicity proton–proton collisions

Quark–gluon plasma is an exotic state of matter that can emerge in heavy nuclei high-energy collisions. The ALICE collaboration reports the first observation of strangeness enhancement in proton–proton collisions, a possible signature of this state.

J. Adam
D. Adamová
M. Zyzak
ResearchOpen Access24 Apr 2017
Nature Physics

Volume: 13, P: 535-539
Cortical morphology in patients with the deficit and non-deficit syndrome of schizophrenia: a worldwide meta- and mega-analyses

Nerisa Banaj
Daniela Vecchio
Federica Piras
ResearchOpen Access29 Aug 2023
Molecular Psychiatry

Volume: 28, P: 4363-4373
Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

Laura K. M. Han
Richard Dinga
Lianne Schmaal
ResearchOpen Access18 May 2020
Molecular Psychiatry

Volume: 26, P: 5124-5139
Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group

Jeanne Leerssen
Tessa F. Blanken
Eus J. W. Van Someren
ResearchOpen Access08 Dec 2020
Translational Psychiatry

Volume: 10, P: 1-11
Trends and outcomes for non-elective neurosurgical procedures in Central Europe during the COVID-19 pandemic

Lukas Grassner
Ondra Petr
David Netuka
ResearchOpen Access17 Mar 2021
Scientific Reports

Volume: 11, P: 1-7
Patterns of schizophrenia symptoms: hidden structure in the PANSS questionnaire

Jérémy Lefort-Besnard
Gaël Varoquaux
Danilo Bzdok
ResearchOpen Access30 Oct 2018
Translational Psychiatry

Volume: 8, P: 1-10
Bordetella pseudohinzii targets cilia and impairs tracheal cilia-driven transport in naturally acquired infection in mice

Alexander Perniss
Nadine Schmidt
Wolfgang Kummer
ResearchOpen Access09 Apr 2018
Scientific Reports

Volume: 8, P: 1-15
Ecological, social, and intrinsic factors affecting wild orangutans’ curiosity, assessed using a field experiment

Caroline Schuppli
Lara Nellissen
Daniel Haun
ResearchOpen Access14 Aug 2023
Scientific Reports

Volume: 13, P: 1-15
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Maja Kopczynska
Harry Unwin
Judith E. Hall
ResearchOpen Access10 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Clinical features and outcomes in primary nervous system histiocytic neoplasms

Nabeela Nathoo
Joon H. Uhm
Lucinda M. Gruber
CorrespondenceOpen Access20 Jun 2024
Blood Cancer Journal

Volume: 14, P: 1-6
ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

Lianne Schmaal
Elena Pozzi
Dick J. Veltman
ReviewsOpen Access29 May 2020
Translational Psychiatry

Volume: 10, P: 1-19

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