Nature Search

Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

Jie Shen
Wander Valentim
Gita A. Pathak
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
Measuring the burden of hundreds of BioBricks defines an evolutionary limit on constructability in synthetic biology

Engineered DNA will slow the growth of a host cell if it redirects limiting resources or otherwise interferes with homeostasis. Here the authors measure how 301 BioBrick plasmids affected Escherichia coli growth and found that 19.6% were burdensome, primarily because they depleted the limited gene expression resources of host cells.

Noor Radde
Genevieve A. Mortensen
Jeffrey E. Barrick
ResearchOpen Access24 Jul 2024
Nature Communications

Volume: 15, P: 1-17
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
A lower critical ordering transition in a diblock copolymer melt

T. P. Russell
T. E. Karis
A. M. Mayes
Research21 Apr 1994
Nature

Volume: 368, P: 729-731
Direct observation of magnetic flux lattice melting and decomposition in the high-T_c superconductor Bi_2.15Sr_1.95CaCu₂O_8+x

R. Cubitt
E. M. Forgan
K. Mortensen
Research30 Sept 1993
Nature

Volume: 365, P: 407-411
Morphology of iodine-doped polyacetylene

M. Rolland
M. Aldissi
F. Schue
Research05 Nov 1981
Nature

Volume: 294, P: 60-61
Inhibition of platelet aggregation by a myeloma protein with anti-phosphocholine specificity

BARRY A. FIEDEL
ALEXANDER P. OSMAND
HENRY GEWURZ
Research01 Oct 1976
Nature

Volume: 263, P: 687-689
Interleukin-3 supports growth of mouse pre-B-cell clones in vitro

Ronald Palacios
Geoffrey Henson
John P. McKearn
Research10 May 1984
Nature

Volume: 309, P: 126-131
Fermentation of Lactose by Cell-free Extracts of Bacillus anthracis

B. R. CHATTERJEE
R. P. WILLIAMS
Research01 Jun 1963
Nature

Volume: 198, P: 909-910
Cancer risk among users of neuroleptic medication: a population-based cohort study

S O Dalton
C Johansen
S Friis
ResearchOpen Access22 Aug 2006
British Journal of Cancer

Volume: 95, P: 934-939
Production of Hydrogen Sulphide by a Thermophilic Blue-green Alga

RICHARD P. SHERIDAN
RICHARD W. CASTENHOLZ
Research16 Mar 1968
Nature

Volume: 217, P: 1063-1064
Bound Carnitine in Bovine Brain

P. R. PROULX
Research21 Dec 1963
Nature

Volume: 200, P: 1210-1211
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Niamh Mullins
Andreas J. Forstner
Ole A. Andreassen
Research17 May 2021
Nature Genetics

Volume: 53, P: 817-829
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD

This study describes an approach to segment and extract key biophysical parameters from live-cell three-dimensional single-molecule imaging trajectories. The authors use this approach to study how NuRD assembles on chromatin and how it regulates enhancer dynamics.

S. Basu
O. Shukron
E. D. Laue
ResearchOpen Access28 Sept 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1628-1639
Associations between common genetic variants and income provide insights about the socio-economic health gradient

This genome-wide association study identifies 162 genetic loci linked to income, shedding light on the complex interplay between genetics, income, education and health.

Hyeokmoon Kweon
Casper A. P. Burik
Philipp D. Koellinger
ResearchOpen Access28 Jan 2025
Nature Human Behaviour

Volume: 9, P: 794-805
Asexual reproduction by oceanic planktotrophic echinoderm larvae

Isidro Bosch
Richard B. Rivkin
Stephen P. Alexander
Research12 Jan 1989
Nature

Volume: 337, P: 169-170
Microscopic coexistence of magnetism and superconductivity in ErNi₂B₂C

U. Yaron
P. L. Gammel
M. R. Eskildsen
Research18 Jul 1996
Nature

Volume: 382, P: 236-238
Photo-antagonism of the GABA_A receptor

The GABA_A receptor has an important role in brain function. Here Mortenson et al. design and synthesize photoactivatable compounds based on the GABA_Aantagonist gabazine and show that these can be used to inactivate the receptor, to identify new residues at the GABA binding site and can be adapted for trafficking studies.

Martin Mortensen
Favaad Iqbal
Trevor G. Smart
ResearchOpen Access29 Jul 2014
Nature Communications

Volume: 5, P: 1-13
CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis

Mehra et al. investigate the role of CdGAP in early biochemical recurrence and bone metastasis in prostate cancer. The authors find that knocking down CdGAP leads to reduced cell motility, invasion and proliferation in PC-3 and 22Rv1 cells while orthotopic injection of CdGAP-depleted PC-3 cells reduces distant metastatic burden.

Chahat Mehra
Ji-Hyun Chung
Nathalie Lamarche-Vane
ResearchOpen Access07 Sept 2021
Communications Biology

Volume: 4, P: 1-15
Demonstration of the tunnel-diode effect on an atomic scale

P. Bedrossian
D. M. Chen
J. A. Golovchenko
Research16 Nov 1989
Nature

Volume: 342, P: 258-260
Genome-wide association study identifies 30 loci associated with bipolar disorder

Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including schizophrenia and depression.

Eli A. Stahl
Gerome Breen
Pamela Sklar
Research01 May 2019
Nature Genetics

Volume: 51, P: 793-803
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

Multi-ancestry genome-wide analyses identify 95 loci associated with post-traumatic stress disorder and implicate candidate genes, pathways and neurobiological systems underlying its pathophysiology.

Caroline M. Nievergelt
Adam X. Maihofer
Karestan C. Koenen
Research18 Apr 2024
Nature Genetics

Volume: 56, P: 792-808
On the Biologic Origin of C₆-C₁₀-Dicarboxylic and C₆-C₁₀-ω-1-Hydroxy Monocarboxylic Acids in Human and Rat with Acyl-CoA Dehydrogenation Deficiencies: in Vitro Studies on the ω- and ω-1-Oxidation of Medium-Chain (C₆-C₁₂) Fatty Acids in Human and Rat Liver

N Gregersen
P B Mortensen
S Kølvraa
Research01 Oct 1983
Pediatric Research

Volume: 17, P: 828-834
Possibility of Incomplete Sex Linkage in Mammals

C. D. DARLINGTON
J. B. S. HALDANE
P. CH. ROLLER
Research17 Mar 1934
Nature

Volume: 133, P: 417
Distinct genetic liability profiles define clinically relevant patient strata across common diseases

Stratified medicine promises to tailor treatment for individual patients, however it remains a major challenge to leverage genetic risk data to aid patient stratification. Here the authors introduce an approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue-specific gene expression levels, and highlight its ability to identify biologically meaningful and clinically actionable patient subgroups, supporting the notion of different patient ‘biotypes’ characterized by partially distinct disease mechanisms.

Lucia Trastulla
Georgii Dolgalev
Michael J. Ziller
ResearchOpen Access01 Jul 2024
Nature Communications

Volume: 15, P: 1-28
Biological Potency of Zeta-Tocopherol

J. BUNYAN
J. GREEN
S. MARCINKIEWICZ
Research23 Feb 1957
Nature

Volume: 179, P: 418-419
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

Alexander Tarakhovsky
Martin Turner
Victor L. J. Tybulewicz
Research30 Mar 1995
Nature

Volume: 374, P: 467-470
High-resolution epidemiological landscape from ~290,000 SARS-CoV-2 genomes from Denmark

A high proportion of confirmed SARS-CoV-2 cases in Denmark were sequenced during the pandemic and linked to demographic, spatial and temporal data. Here, the authors analyse 290,000 genomes sampled in 2021 to demonstrate the value of this high coverage, detailed data set.

Mark P. Khurana
Jacob Curran-Sebastian
Samir Bhatt
ResearchOpen Access20 Aug 2024
Nature Communications

Volume: 15, P: 1-16
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent risk loci. Comparisons with other psychiatric disorders and candidate gene analyses provide new insights into major depressive disorder.

Naomi R. Wray
Stephan Ripke
Patrick F. Sullivan
Research26 Apr 2018
Nature Genetics

Volume: 50, P: 668-681
Modification of a Soil Percolation Apparatus for Soils of a High Organic Matter Content

T. M. B. PAYNE
P. H. H. GRAY
Research23 Aug 1952
Nature

Volume: 170, P: 325
Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

Debabrata Mukhopadhyay
Leonidas Tsiokas
Vikas P. Sukhatme
Research15 Jun 1995
Nature

Volume: 375, P: 577-581
Imaging tumour hypoxia with positron emission tomography

I N Fleming
R Manavaki
F J Gilbert
ReviewsOpen Access16 Dec 2014
British Journal of Cancer

Volume: 112, P: 238-250
Is annual reproduction in deep-sea echinoderms a response to variability in their environment?

P. A. Tyler
A. Grant
J. D. Gage
Research23 Dec 1982
Nature

Volume: 300, P: 747-750
Citrullinated and MMP-degraded vimentin is associated with chronic pulmonary diseases and genetic variants in PADI3/PADI4 and CFH in postmenopausal women

Cecilie Liv Bager
Joseph P. M. Blair
Morten Asser Karsdal
ResearchOpen Access27 Dec 2023
Scientific Reports

Volume: 13, P: 1-8
An atomic switch realized with the scanning tunnelling microscope

D. M. Eigler
C. P. Lutz
W. E. Rudge
Research15 Aug 1991
Nature

Volume: 352, P: 600-603
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

This study uses gene expression predictors for the dorsolateral prefrontal cortex and other brain regions to perform a transcriptomic imputation analysis of schizophrenia, identifying 413 genic associations across 13 brain regions and 36 significantly enriched pathways.

Laura M. Huckins
Amanda Dobbyn
Eli A. Stahl
Research25 Mar 2019
Nature Genetics

Volume: 51, P: 659-674
Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

Establishing the relative transmissibility of emerging variants of SARS-CoV-2 is key for pandemic management. Here, the authors use full-population administrative data from Denmark linked to PCR test results and estimate that the Alpha variant was ~60% higher than other strains circulating in early 2021.

Frederik Plesner Lyngse
Kåre Mølbak
Carsten Thure Kirkeby
ResearchOpen Access13 Dec 2021
Nature Communications

Volume: 12, P: 1-8
Regulation of embryonic growth and lysosomal targeting by the imprintedIgf2/Mpr gene

Zhao-Qi Wang
Marion R. Fung
Erwin F. Wagner
Research01 Dec 1994
Nature

Volume: 372, P: 464-467
Two different areas within the primary motor cortex of man

Stefan Geyer
Anders Ledberg
Per E. Roland
Research29 Aug 1996
Nature

Volume: 382, P: 805-807
A Palaeocene proboscidean from Morocco

Emmanuel Gheerbrant
Jean Sudre
Henri Cappetta
Research05 Sept 1996
Nature

Volume: 383, P: 68-70
Rare coding variants in ten genes confer substantial risk for schizophrenia

Whole-exome sequencing identifies ten risk genes for schizophrenia implicated by rare protein-coding variants, a subset of which overlap with risk genes in other neurodevelopmental disorders.

Tarjinder Singh
Timothy Poterba
Mark J. Daly
Research08 Apr 2022
Nature

Volume: 604, P: 509-516
Deep structure of an Archaean greenstone terrane

A. G. Green
B. Milkereit
A. Simard
Research22 Mar 1990
Nature

Volume: 344, P: 327-330
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Post-traumatic stress disorder (PTSD) is a common mental health problem. Here, the authors report a GWAS from the Psychiatric Genomics Consortium in which they identify two risk loci in European ancestry and one locus in African ancestry individuals and find that PTSD is genetically correlated with several other psychiatric traits.

Caroline M. Nievergelt
Adam X. Maihofer
Karestan C. Koenen
ResearchOpen Access08 Oct 2019
Nature Communications

Volume: 10, P: 1-16
Plant species’ origin predicts dominance and response to nutrient enrichment and herbivores in global grasslands

It remains unclear whether exotic and native species are functionally different. Using a global grassland experiment, Seabloomet al. show that native and exotic species respond differently to two globally pervasive environmental changes, addition of mineral nutrients and alteration of herbivore density.

Eric W. Seabloom
Elizabeth T. Borer
Louie Yang
ResearchOpen Access15 Jul 2015
Nature Communications

Volume: 6, P: 1-8
Increased potency of an erythropoietin peptide mimetic through covalent dimerization

Nicholas C. Wrighton
Palaniappan Balasubramanian
William J. Dower
Research01 Nov 1997
Nature Biotechnology

Volume: 15, P: 1261-1265
Electronic states and phases of K_xC₆₀ from photoemission and X-ray absorption spectroscopy

C. T. Chen
L. H. Tjeng
E. W. Plummer
Research15 Aug 1991
Nature

Volume: 352, P: 603-605
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

A genome-wide association study for attention deficit/hyperactivity disorder (ADHD) identifies 12 loci and implicates neurodevelopmental pathways and conserved regions of the genome as being involved in underlying ADHD biology.

Ditte Demontis
Raymond K. Walters
Benjamin M. Neale
Research26 Nov 2018
Nature Genetics

Volume: 51, P: 63-75

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