Nature Search

Identification of undetected SARS-CoV-2 infections by clustering of Nucleocapsid antibody trajectories

Many SARS-CoV-2 infections may go undetected through conventional PCR or lateral flow tests. Here, the authors analyse the utility of analysing longitudinal nucleocapsid antibody trajectories to improve identification of prior SARS-CoV-2 infections using surveillance data from the UK.

Leslie R. Zwerwer
Tim E. A. Peto
Chris Cunningham
ResearchOpen Access14 May 2025
Nature Communications

Volume: 16, P: 1-13
Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population

The factors influencing risk of reinfection with SARS-CoV-2 are poorly understood. Here, the authors use data from the UK COVID-19 Infection Survey, a community based longitudinal study, to assess characteristics of ~45,000 reinfections compared to initial infections.

Jia Wei
Nicole Stoesser
Chris Cunningham
ResearchOpen Access02 Feb 2024
Nature Communications

Volume: 15, P: 1-14
Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification

Estimates of infection rates from the UK COVID-19 Infection Survey may have been biased by the characteristics of people who chose to take part. Here, the authors show that the survey population had unusually high vaccination rates and adjust infection estimates taking this into account.

Koen B. Pouwels
David W. Eyre
Chris Cunningham
ResearchOpen Access24 Jun 2024
Nature Communications

Volume: 15, P: 1-12
A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors

Confining plasma and managing disruptions in tokamak devices is a challenge. Here the authors demonstrate a method predicting and possibly preventing disruptions and macroscopic instabilities in tokamak plasma using data from JET.

Andrea Murari
Riccardo Rossi
Michela Gelfusa
ResearchOpen Access18 Mar 2024
Nature Communications

Volume: 15, P: 1-19
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits

The RNA for ALS- and frontotemporal dementia-associated C9ORF72 gene is exported from nucleus via an unknown mechanism. This study shows that reduction of nuclear export adaptor SRSF1 can alleviate neuronal cell death and nuclear export of C9ORF72 inDrosophilaand patient-derived induced motor neurons.

Guillaume M. Hautbergue
Lydia M. Castelli
Pamela J. Shaw
ResearchOpen Access05 Jul 2017
Nature Communications

Volume: 8, P: 1-18
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

Post-acute sequelae of SARS-CoV-2 (PASC) is still not well understood. Here the authors provide patient reported outcomes from 590 hospitalized COVID-19 patients and show association of PASC with higher respiratory SARS-CoV-2 load and circulating antibody titers, and in some an elevation in circulating fibroblast growth factor 21.

Al Ozonoff
Naresh Doni Jayavelu
Nadine Rouphael
ResearchOpen Access03 Jan 2024
Nature Communications

Volume: 15, P: 1-17
SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection

The impact of prior infection on the immune response to COVID-19 vaccination has not been fully characterised. Here, the authors use data from ~100,000 adults in the UK and find that a single vaccine dose in those with prior infection produces a comparable or stronger response to two doses in those without infection.

Jia Wei
Philippa C. Matthews
Chris Cunningham
ResearchOpen Access29 Jun 2022
Nature Communications

Volume: 13, P: 1-9
Anti-spike antibody response to natural SARS-CoV-2 infection in the general population

Most people who are infected with SARS-CoV-2 seroconvert within a few weeks, but the determinants and duration of the antibody response are not known. Here, the authors characterise these features of the immune response using data from a large representative community sample of the UK population.

Jia Wei
Philippa C. Matthews
Chris Cunningham
ResearchOpen Access29 Oct 2021
Nature Communications

Volume: 12, P: 1-12
Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom

Longitudinal tracing of antibody responses to the ChAdOx1 and the BNT162b2 COVID-19 vaccines in 45,965 adults from the United Kingdom give indications for vaccine prioritization.

Jia Wei
Nicole Stoesser
Jessica Lee
ResearchOpen Access21 Jul 2021
Nature Microbiology

Volume: 6, P: 1140-1149
Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK

The duration and strength of protection against SARS-CoV-2 infection resulting from a booster vaccine dose or breakthrough infection are not well understood. This study uses data from the UK COVID-19 Infection Survey to investigate correlates of protection against Omicron BA.4/5 infection and assess antibody responses to booster vaccination and breakthrough infections.

Jia Wei
Philippa C. Matthews
Chris Cunningham
ResearchOpen Access16 May 2023
Nature Communications

Volume: 14, P: 1-15
Enhanced performance in fusion plasmas through turbulence suppression by megaelectronvolt ions

Experiments at the Joint European Torus tokamak show improved thermal ion confinement in the presence of highly energetic ions and Alfvénic instabilities in the plasma.

S. Mazzi
J. Garcia
I. Zychor
Research30 Jun 2022
Nature Physics

Volume: 18, P: 776-782
Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines

A large study in the United Kingdom shows that virus-specific antibody levels associated with at least 67% protection against SARS-CoV-2 Delta variant infection last longer after two doses of BNT162b2 vaccine than after two doses of ChAdOx1 vaccine in previously uninfected individuals.

Jia Wei
Koen B. Pouwels
Chris Cunningham
ResearchOpen Access14 Feb 2022
Nature Medicine

Volume: 28, P: 1072-1082
NTSR1 glycosylation and MMP dependent cleavage generate three distinct forms of the protein

Fotine Libanje
Raphael Delille
Stephan Klinz
ResearchOpen Access22 Mar 2023
Scientific Reports

Volume: 13, P: 1-16
Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples

A method enabling copy-number analysis of single cells from formalin-fixed paraffin-embedded samples is described, validated and applied to analyze samples of synchronous ductal carcinoma in situ and invasive breast carcinoma.

Luciano G Martelotto
Timour Baslan
Jorge S Reis-Filho
Research06 Feb 2017
Nature Medicine

Volume: 23, P: 376-385
COVID-19 vaccination, risk-compensatory behaviours, and contacts in the UK

John Buckell
Joel Jones
Helen Fryer
ResearchOpen Access25 May 2023
Scientific Reports

Volume: 13, P: 1-15
Disruption prediction with artificial intelligence techniques in tokamak plasmas

Tokamak plasmas are prone to sudden collapses that terminate the nuclear fusion reactions. This perspective discusses the prediction of these so-called disruptions with artificial intelligence techniques.

J. Vega
A. Murari
I. Zychor
Reviews06 Jun 2022
Nature Physics

Volume: 18, P: 741-750
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Cord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety

Douglas C. Dean III
Andy Madrid
Pamela J. Kling
ResearchOpen Access09 Jun 2021
Scientific Reports

Volume: 11, P: 1-12
A collaborative and near-comprehensive North Pacific humpback whale photo-ID dataset

Ted Cheeseman
Ken Southerland
Phil Clapham
ResearchOpen Access23 Jun 2023
Scientific Reports

Volume: 13, P: 1-17

Search

Identification of undetected SARS-CoV-2 infections by clustering of Nucleocapsid antibody trajectories

Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population

Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification

A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits

Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection

Anti-spike antibody response to natural SARS-CoV-2 infection in the general population

Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom

Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK

Enhanced performance in fusion plasmas through turbulence suppression by megaelectronvolt ions

Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines

NTSR1 glycosylation and MMP dependent cleavage generate three distinct forms of the protein

Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples

COVID-19 vaccination, risk-compensatory behaviours, and contacts in the UK

Disruption prediction with artificial intelligence techniques in tokamak plasmas

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Cord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety

A collaborative and near-comprehensive North Pacific humpback whale photo-ID dataset

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