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PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression

The integrated stress response (ISR) allows cells to restore cellular homeostasis upon a wide range of stress stimuli. Here, the authors show that PIM2 inhibition activates the ISR and promotes NOXA expression, in turn making tumour cells vulnerable to MCL1 inhibition.

Marion Haas
Sabrina Cherfa
Thierry Fest
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-20
P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia

Wood and colleagues report that the XPO1 inhibitor selinexor activates PI3Ky-dependent AKT signaling in AML via upregulation of P2RY2 and demonstrate a synergistic effect of combining selinexor with inhibition of prosurvival AKT signaling.

Kevin H. Lin
Justine C. Rutter
Kris C. Wood
Research06 Jun 2022
Nature Cancer

Volume: 3, P: 837-851
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

Transcriptomic and metabolic profiling reveals that the creatine kinase pathway is essential for growth of acute myeloid leukemias expressing the transcription factor EVI1.

Nina Fenouille
Christopher F Bassil
Kimberly Stegmaier
Research13 Feb 2017
Nature Medicine

Volume: 23, P: 301-313
Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice

Here, the authors present the upstream pathway that controls the activation of the NLRP3 inflammasome during bacteraemia. The CNF1 toxin from Escherichia coli activates the Rho GTPase Rac2 and its activity is sensed by NLRP3, which is activated by a signalling cascade involving p21-activated kinases 1 and 2.

Océane Dufies
Anne Doye
Laurent Boyer
Research11 Jan 2021
Nature Microbiology

Volume: 6, P: 401-412
IL-34 and CSF-1 display an equivalent macrophage differentiation ability but a different polarization potential

Sonia Boulakirba
Anja Pfeifer
Arnaud Jacquel
ResearchOpen Access10 Jan 2018
Scientific Reports

Volume: 8, P: 1-11
Retraction Note: LAMP2 expression dictates azacytidine response and prognosis in MDS/AML

Alix Dubois
Nathan Furstoss
Guillaume Robert
Amendments and CorrectionsOpen Access14 Jul 2020
Leukemia

Volume: 34, P: 2544
RETRACTED ARTICLE: LAMP2 expression dictates azacytidine response and prognosis in MDS/AML

Alix Dubois
Nathan Furstoss
Guillaume Robert
Research03 Jan 2019
Leukemia

Volume: 33, P: 1501-1513
The oncogenic tyrosine kinase Lyn impairs the pro-apoptotic function of Bim

Lazaro E. Aira
Elodie Villa
Sandrine Marchetti
Research02 Feb 2018
Oncogene

Volume: 37, P: 2122-2136
REDD1 is a gatekeeper of murine hematopoietic stem cell functions during stress responses

Vilma Barroca
Elia Henry
Marie-Laure Arcangeli
Research31 May 2022
Leukemia

Volume: 36, P: 2140-2143
Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation

Frederic Luciano
Jean-Ehrland Ricci
Patrick Auberger
Research28 Aug 2001
Oncogene

Volume: 20, P: 4935-4941
Differential requirements for ERK1/2 and P38 MAPK activation by thrombin in T cells. Role of P59Fyn and PKCε

Laurence Maulon
Bernard Mari
Patrick Auberger
Research12 Apr 2001
Oncogene

Volume: 20, P: 1964-1972
Cleavage and relocation of the tyrosine kinase P59FYN during Fas-mediated apoptosis in T lymphocytes

Jean-Ehrland Ricci
Laurence Maulon
Patrick Auberger
Research14 Jul 1999
Oncogene

Volume: 18, P: 3963-3969
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function

Frederic Luciano
Arnaud Jacquel
Patrick Auberger
Research02 Oct 2003
Oncogene

Volume: 22, P: 6785-6793
Helicobacter pylori Lipopolysaccharide Hinders Polymorphonuclear Leucocyte Apoptosis

Véronique Hofman
Vittorio Ricci
Paul Hofman
Research01 Mar 2001
Laboratory Investigation

Volume: 81, P: 375-384
High caspase 3 and vulnerability to dual BCL2 family inhibition define ETO2::GLIS2 pediatric leukemia

Zakia Aid
Elie Robert
Thomas Mercher
Research30 Dec 2022
Leukemia

Volume: 37, P: 571-579
Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma

Dufies et al. find high Plk1 expression levels in aggressive clear cell renal cell carcinoma and discover that Plk1 is transcriptionally upregulated in a manner dependent on HIF-2. They also find that high Plk1 expression is correlated to a poor prognosis and resistance to tyrosine kinase inhibitor against VEGF receptor, suggesting a critical role for hypoxia/HIF-2-induced Plk1 in disease progression.

Maeva Dufies
Annelies Verbiest
Gilles Pagès
ResearchOpen Access05 Feb 2021
Communications Biology

Volume: 4, P: 1-16
The protective effect of phorbol esters on Fas-mediated apoptosis in T cells. Transcriptional and postranscriptional regulation

Magali Herrant
Frédéric Luciano
Patrick Auberger
Research16 Jul 2002
Oncogene

Volume: 21, P: 4957-4968
Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis

Magali Herrant
Arnaud Jacquel
Patrick Auberger
Research20 Sept 2004
Oncogene

Volume: 23, P: 7863-7873
The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production

G Robert
A Puissant
P Auberger
Research04 May 2012
Cell Death & Differentiation

Volume: 19, P: 1769-1778
CXCL7 is a predictive marker of sunitinib efficacy in clear cell renal cell carcinomas

Maeva Dufies
Sandy Giuliano
Gilles Pagès
ResearchOpen Access29 Aug 2017
British Journal of Cancer

Volume: 117, P: 947-953
Blocking NF-κB activation in Jurkat leukemic T cells converts the survival agent and tumor promoter PMA into an apoptotic effector

Valère Busuttil
Virginie Bottero
Jean-François Peyron
Research07 May 2002
Oncogene

Volume: 21, P: 3213-3224
Gene expression profiling of normal human pulmonary fibroblasts following coculture with non-small-cell lung cancer cells reveals alterations related to matrix degradation, angiogenesis, cell growth and survival

Olivia Fromigué
Krystel Louis
Bernard Mari
Research20 Nov 2003
Oncogene

Volume: 22, P: 8487-8497
Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases

Céline Charvet
Isabelle Alberti
Marcel Deckert
Research17 Jul 2003
Oncogene

Volume: 22, P: 4557-4568
Evidence for a p23 caspase-cleaved form of p27^[KIP1] involved in G₁ growth arrest

Agnès Loubat
Nathalie Rochet
Gilles Ponzio
Research14 Jun 1999
Oncogene

Volume: 18, P: 3324-3333

Search

PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression

P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice

IL-34 and CSF-1 display an equivalent macrophage differentiation ability but a different polarization potential

Retraction Note: LAMP2 expression dictates azacytidine response and prognosis in MDS/AML

RETRACTED ARTICLE: LAMP2 expression dictates azacytidine response and prognosis in MDS/AML

The oncogenic tyrosine kinase Lyn impairs the pro-apoptotic function of Bim

REDD1 is a gatekeeper of murine hematopoietic stem cell functions during stress responses

Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation

Differential requirements for ERK1/2 and P38 MAPK activation by thrombin in T cells. Role of P59Fyn and PKCε

Cleavage and relocation of the tyrosine kinase P59FYN during Fas-mediated apoptosis in T lymphocytes

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function

Helicobacter pylori Lipopolysaccharide Hinders Polymorphonuclear Leucocyte Apoptosis

High caspase 3 and vulnerability to dual BCL2 family inhibition define ETO2::GLIS2 pediatric leukemia

Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma

The protective effect of phorbol esters on Fas-mediated apoptosis in T cells. Transcriptional and postranscriptional regulation

Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis

The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production

CXCL7 is a predictive marker of sunitinib efficacy in clear cell renal cell carcinomas

Blocking NF-κB activation in Jurkat leukemic T cells converts the survival agent and tumor promoter PMA into an apoptotic effector

Gene expression profiling of normal human pulmonary fibroblasts following coculture with non-small-cell lung cancer cells reveals alterations related to matrix degradation, angiogenesis, cell growth and survival

Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases

Evidence for a p23 caspase-cleaved form of p27^[KIP1] involved in G₁ growth arrest

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