Light controls animal circadian behavior by regulating gene expression in the circadian clock. Here, Cao et al. reports that a light-activated MAPK/MNK pathway leads to phosphorylation of the cap-binding protein eIF4E and promotes mRNA translation of the clock gene Period 1 and 2 to facilitate clock resetting.
- Ruifeng Cao
- Christos G Gkogkas
- Nahum Sonenberg