Nature Search

Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity

Tutas et al. show an unconventional role for autophagy in the regulation of glycolytic flux in cerebellar Purkinje cells by maintaining the levels of the glucose transporter GLUT2.

Janine Tutas
Marianna Tolve
Natalia L. Kononenko
ResearchOpen Access15 Jan 2025
Nature Metabolism

Volume: 7, P: 297-320
Neanderthal ancestry drives evolution of lipid catabolism in contemporary Europeans

Modern human genomes contain Neanderthal sequences, but it is unclear whether these were selected. Here, Khrameeva et al.show that Neanderthal sequences associated with lipid catabolism are three times more frequent in Europe, suggesting that these sequences might have been beneficial to Europeans.

Ekaterina E. Khrameeva
Katarzyna Bozek
Philipp Khaitovich
ResearchOpen Access01 Apr 2014
Nature Communications

Volume: 5, P: 1-8
Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver

Dysfunctions of the mitochondrial OXPHOS system lead to severe human disorders. Here, the authors analyzed a mouse mutant that mimics a mitochondrial disorder patient and find that reactive oxygen species trigger RNA release and inflammatory pathway in liver.

Abhishek Aich
Angela Boshnakovska
Peter Rehling
ResearchOpen Access12 Aug 2024
Nature Communications

Volume: 15, P: 1-20
Small-molecule inhibitors of human mitochondrial DNA transcription

Inhibitors of mitochondrial transcription that target human mitochondrial RNA polymerase provide a chemical biology tool for studying the role of mitochondrial DNA expression in a wide range of pathologies.

Nina A. Bonekamp
Bradley Peter
Nils-Göran Larsson
Research16 Dec 2020
Nature

Volume: 588, P: 712-716
Lipidome determinants of maximal lifespan in mammals

Katarzyna Bozek
Ekaterina E. Khrameeva
Philipp Khaitovich
ResearchOpen Access31 Jan 2017
Scientific Reports

Volume: 7, P: 1-10
Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7

Deshwal et al. show that the protease PARL regulates coenzyme Q (CoQ) via the lipid transfer protein STARD7. Mitochondrial STARD7 ensures CoQ synthesis; cytosolic STARD7 preserves CoQ transport to the membrane, protecting cells against ferroptosis.

Soni Deshwal
Mashun Onishi
Thomas Langer
ResearchOpen Access19 Jan 2023
Nature Cell Biology

Volume: 25, P: 246-257
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

Viruses manipulate host cell pathways to support infection. Here the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.

Nils C. Gassen
Jan Papies
Marcel A. Müller
ResearchOpen Access21 Jun 2021
Nature Communications

Volume: 12, P: 1-15
Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells

Aged mesenchymal stem cells exhibit decreased osteogenesis. Pouikli et al. link impaired MSC differentiation to histone hypoacetylation caused by lower mitochondrial acetyl-CoA export due to enhanced lysosomal degradation of the citrate carrier Slc25a1. Restoring histone acetylation to youthful levels rescues osteogenesis.

Andromachi Pouikli
Swati Parekh
Peter Tessarz
ResearchOpen Access13 Sept 2021
Nature Aging

Volume: 1, P: 810-825
Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity

Sprenger et al. find that cytosolic pyrimidine levels regulate the release of mitochondrial DNA and activation of cGAS–STING.

Hans-Georg Sprenger
Thomas MacVicar
Thomas Langer
ResearchOpen Access26 Apr 2021
Nature Metabolism

Volume: 3, P: 636-650
Bioinformatic and expression analysis of the Brassica napus L. cyclophilins

Patrizia Hanhart
Melanie Thieß
Julia Kehr
ResearchOpen Access04 May 2017
Scientific Reports

Volume: 7, P: 1-17
Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity

Inhibitor of mitochondrial transcription treatment leads to reduced oxidative phosphorylation capacity but increases fatty acid oxidation in the liver, leading to protection from obesity and related pathology.

Shan Jiang
Taolin Yuan
Nils-Göran Larsson
ResearchOpen Access30 Apr 2024
Nature Metabolism

Volume: 6, P: 1024-1035
Spatial and single-cell profiling of the metabolome, transcriptome and epigenome of the aging mouse liver

Using spatial and single-cell multiomics, Nikopoulou et al analyze how different cells within the mouse liver age, revealing zonation-specific aging trajectories and highlighting the importance of the local tissue microenvironment.

Chrysa Nikopoulou
Niklas Kleinenkuhnen
Peter Tessarz
ResearchOpen Access09 Nov 2023
Nature Aging

Volume: 3, P: 1430-1445
Differences in lipidome and metabolome organization of prefrontal cortex among human populations

Anna Tkachev
Vita Stepanova
Philipp Khaitovich
ResearchOpen Access04 Dec 2019
Scientific Reports

Volume: 9, P: 1-10
Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

This Perspective, from a large group of metabolomics experts, provides best practices and simplified reporting guidelines for practitioners of liquid chromatography– and gas chromatography–mass spectrometry-based metabolomics.

Saleh Alseekh
Asaph Aharoni
Alisdair R. Fernie
Reviews08 Jul 2021
Nature Methods

Volume: 18, P: 747-756
Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders

Qianhui Yu
Zhisong He
Philipp Khaitovich
ResearchOpen Access08 Aug 2018
Molecular Psychiatry

Volume: 25, P: 2952-2969
The AtMYB60 transcription factor regulates stomatal opening by modulating oxylipin synthesis in guard cells

Fabio Simeoni
Aleksandra Skirycz
Massimo Galbiati
ResearchOpen Access11 Jan 2022
Scientific Reports

Volume: 12, P: 1-12
Publisher Correction: Lipidome determinants of maximal lifespan in mammals

Katarzyna Bozek
Ekaterina E. Khrameeva
Philipp Khaitovich
Amendments and CorrectionsOpen Access01 May 2019
Scientific Reports

Volume: 9, P: 1
Metabolome signature of autism in the human prefrontal cortex

Kurochkin, Khrameeva et al. show differences in metabolite intensities within the prefrontal cortex of individuals with autism spectrum disorders (ASD) that converge into 16 cellular pathways. Parallel measurements conducted in primates also revealed unique metabolite intensity differences unique to humans, highlighting unique evolutionary cortical mechanism in ASD.

Ilia Kurochkin
Ekaterina Khrameeva
Philipp Khaitovich
ResearchOpen Access21 Jun 2019
Communications Biology

Volume: 2, P: 1-10
Unraveling local tissue changes within severely injured skeletal muscles in response to MSC-based intervention using MALDI Imaging mass spectrometry

Oliver Klein
Kristin Strohschein
Sven Geissler
ResearchOpen Access23 Aug 2018
Scientific Reports

Volume: 8, P: 1-11

Search

Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity

Neanderthal ancestry drives evolution of lipid catabolism in contemporary Europeans

Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver

Small-molecule inhibitors of human mitochondrial DNA transcription

Lipidome determinants of maximal lifespan in mammals

Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells

Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity

Bioinformatic and expression analysis of the Brassica napus L. cyclophilins

Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity

Spatial and single-cell profiling of the metabolome, transcriptome and epigenome of the aging mouse liver

Differences in lipidome and metabolome organization of prefrontal cortex among human populations

Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders

The AtMYB60 transcription factor regulates stomatal opening by modulating oxylipin synthesis in guard cells

Publisher Correction: Lipidome determinants of maximal lifespan in mammals

Metabolome signature of autism in the human prefrontal cortex

Unraveling local tissue changes within severely injured skeletal muscles in response to MSC-based intervention using MALDI Imaging mass spectrometry

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