Nature Search

ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors

CAR T cell success requires targeting tumors, but these cells can get trapped in other tissues, such as in the lungs, where they can cause pathology. Here, the authors use a loss-of-function CRISPR screen to identify regulators of CAR T cell tumor trafficking and engineer CAR T cells accordingly to overcome this limitation.

Yeonsun Hong
Brandon L. Walling
Minsoo Kim
Research17 Apr 2023
Nature Immunology

Volume: 24, P: 1007-1019
A transcriptomic atlas of aged human microglia

Aging is associated with various changes in the brain, including transcription alteration. Here, Bradshaw and colleagues describe the transcriptome of aged human cortical microglia, and show age-related gene expression as related to neurodegeneration.

Marta Olah
Ellis Patrick
Elizabeth M. Bradshaw
ResearchOpen Access07 Feb 2018
Nature Communications

Volume: 9, P: 1-8
Regulation of lifespan by neural excitation and REST

Studies of humans, mice and nematodes reveal a conserved role of neural activity and the transcription factor REST in extended longevity.

Joseph M. Zullo
Derek Drake
Bruce A. Yankner
Research16 Oct 2019
Nature

Volume: 574, P: 359-364
A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

The authors constructed and validated a molecular network of the aging human cortex from RNA sequencing data from 478 individuals and identified genes that affect cognitive decline or neuropathology in Alzheimer’s disease.

Sara Mostafavi
Chris Gaiteri
Philip L. De Jager
Research25 May 2018
Nature Neuroscience

Volume: 21, P: 811-819
A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus

Cue reactivity measured by functional magnetic resonance imaging is used in studies of substance-use disorders. This Consensus Statement is the result of a Delphi process to arrive at parameters that should be reported in describing these studies.

Hamed Ekhtiari
Mehran Zare-Bidoky
Anna Zilverstand
Reviews04 Feb 2022
Nature Protocols

Volume: 17, P: 567-595
A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies

Ellis Patrick
Marta Olah
Philip L. De Jager
ResearchOpen Access14 Jan 2021
Translational Psychiatry

Volume: 11, P: 1-17
Chinese scientists and US leadership in the life sciences

Steven H. Holtzman
Ron Cohen
Shuguang Zhang
Correspondence03 Oct 2019
Nature Biotechnology

Volume: 37, P: 1261-1263
EmbryoNet: using deep learning to link embryonic phenotypes to signaling pathways

EmbryoNet is an automated approach to the phenotyping of developing embryos that surpasses experts in terms of speed, accuracy and sensitivity. A large annotated image dataset of zebrafish, medaka and stickleback development rounds out this resource.

Daniel Čapek
Matvey Safroshkin
Patrick Müller
ResearchOpen Access08 May 2023
Nature Methods

Volume: 20, P: 815-823
The acute phase protein lactoferrin is a key feature of Alzheimer’s disease and predictor of Aβ burden through induction of APP amyloidogenic processing

Andrew Tsatsanis
Andrew N. McCorkindale
James A. Duce
ResearchOpen Access16 Aug 2021
Molecular Psychiatry

Volume: 26, P: 5516-5531
Amyloidogenesis via interfacial shear in a containerless biochemical reactor aboard the International Space Station

Patrick McMackin
Joe Adam
Amir Hirsa
ResearchOpen Access20 Sept 2022
npj Microgravity

Volume: 8, P: 1-8
Functional arrays of human pluripotent stem cell-derived cardiac microtissues

Nimalan Thavandiran
Christopher Hale
Peter W. Zandstra
ResearchOpen Access24 Apr 2020
Scientific Reports

Volume: 10, P: 1-13
Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells

Min Kang
Kay Yi Chong
Yang Yang-Hartwich
ResearchOpen Access29 May 2020
Oncogenesis

Volume: 9, P: 1-15

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