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Robust attachment between living tissues and inert materials is challenging to achieve. Here, Hwang and co-workers look at the molecular level between tissue and embedded byssal threads of Atrina pectinata and how this affects tenacity, toughness, and robustness.

Here, the authors report on the thermal and mechanical properties of Ruddlesden-Popper phases (Ban+1ZrnS3n+1, n = 2 and 3) of a perovskite chalcogenide (BaZrS3) that push to extreme limits and defy the century-old relation between thermal conductivity and interatomic bond strength.

Self-organized criticality can occur in cellular systems, but its origins remain unclear. Now it is shown that cytoskeletal criticality is influenced by the F-actin architecture and myosin active stress.

Invasive cells respond to contact guidance cues during migration. Here, using micro- and nanopatterning with different ligands and varying stiffness, the authors find that cells can make cellular protrusions through both contractility-dependent and contractility-independent means.

3D-printed soft actuators have limited motion and are far from reaching the level of complexity found in biological systems. Here the authors present a multimaterial 3D printing platform for the fabrication of soft actuators displaying a wide range of motions that are programmable.

Aurora, a new large-scale foundation model trained on more than one million hours of diverse geophysical data, outperforms operational forecasts in predicting air quality, ocean wave dynamics, tropical cyclone tracks and high-resolution weather.

Regioselectivity during electrophilic aromatic substitution is typically controlled by substituents on the aryl group. Here the authors report an electrophilic aromatic substitution reaction, wherein remote chiral ester groups direct the electrophile to a precise ___location on the molecule.

Mesenchymal stromal cells singly coated with a soft conformal gel incorporating specific chemomechanical cues inhibit aberrant tissue remodelling in mice with fibrotic lung injury.

Laminin, an important component of the extracellular matrix supporting the epithelium, hinders the typical mechanoresponse of epithelial cells to an increase in substrate stiffness, by protecting the cell nucleus from mechanical deformation.

Liquid crystals are grouped into four main classes—nematic, lamellar, cubic and columnar—depending on their symmetries. Here, the authors show for the first time that a columnar phase can form in suspensions of imogolite nanotubes at very low concentrations.

Old Masters used paints containing mixtures of oils and proteins, but we lack an understanding on how and why proteins were used. Here, the authors use egg yolk in combination with two pigments to evaluate how different repartition of proteinaceous binder can be used to control the flow behaviour as well as drying kinetics and chemistry of oil paints.

A nanoscale tube-in-tube sandwich structure is generated by a two-step templating-pyrolysis process, which strengthens the log-pile carbon architecture and slows down the decrease of stiffness with decreasing density.

Sakata et al. performed a prospective personalized mechanistic computational (digital twin) study focused on characterizing the arrhythmogenic properties of the atrial fibrotic substrate in patients with persistent atrial fibrillation, and they introduce here a novel mechanism-oriented strategy for optimal ablation.

Knitted fabrics are prized for their stretchability, breathability, and long-wearability in everyday life. This study combines experiments and simulations to present a micromechanical approach to understanding the origin of the anisotropic elasticity of four canonical patterns of knitted fabrics.

Bottom-up in vitro reconstitution of ~10-kb chromatin domains shows that nucleosome positioning, rather than loop extrusion or transcription, determines ___domain formation in yeast.

Breeding has increased crop productivity, but whether it has also changed phenotypic plasticity is unclear. Here, the authors find maize genomic regions selected for high productivity show reduced contribution to genotype by environment variation and provide evidence for regulatory control of phenotypic stability.

Silicon is a promising electrode material for lithium-ion batteries; however, morphological changes shorten battery lifetimes. Here the authors use imaging techniques based on electrons and X-rays to quantify such processes at micro- and nanoscales and suggest routes to mitigate battery degradation.

A portable ankle exoskeleton uses a data-driven method and wearable sensors to adapt to the user as they walk in a natural setting.

Conducting a simulated turtlegrass herbivory experiment across 650 experimental plots and 13 seagrass meadows, the authors show that the negative effects of herbivory increase with latitude, driven by low levels of light insolation at high latitudes.

A cluster randomized trial in Tanzania showed that the implementation of a decision support algorithm decreased antibiotic prescriptions to children considerably, without impacting clinical outcomes.

Measuring interaction energies from experimentally measured single-molecular interactions is challenging. Here, the authors report a gamma work distribution applied to single molecule pulling events for estimating peptide absorption free energy.

Intrinsically disordered FG-Nups line the Nuclear Pore Complex (NPC) lumen and form a selective barrier where transport of most proteins is inhibited, whereas specific transporter proteins are able to pass. Here, the authors reconstitute the selective behaviour of the NPC by introducing a rationally designed artificial FG-Nup that demonstrates that no specific spacer sequence nor a spatial segregation of different FG-motif types are needed to create selective NPCs.

Although using low-rank matrices is the go-to approach to model the dynamics of complex systems, its validity remains formally unconfirmed. An analysis of random networks and real-world data now sheds light on this low-rank hypothesis and its implications.

Merging the generalized extracellular molecule sensor (GEMS) system with screening designed ankyrin repeat proteins (DARPins) identifies an advanced modular bispecific extracellular receptor (AMBER) for detection of fibrinogen degradation products.

Stacked elastomeric arrays containing plasmonic nanoparticles show efficient chiral responses that can be fully controlled by mechanical compression and stack rotation. These simple layered materials may be useful modulators for photonic applications.

Hypomethylating agents, such as 5-Azacytidine (5-AZA), are standard of care for patients with myelodysplastic and myeloid malignancies, however response rates are limited and risk of relapses high. Here the authors show that inhibition of lysyl oxidases synergizes with 5-AZA to improve erythropoiesis and reduce disease burden in myelodysplastic neoplasms models.

Broomcorn millet is one of the earliest domesticated plants and has the highest water use efficiency among cereals. Here, the authors report its genome assembly and annotation, which provides a valuable resource for breeders and paves the way for studying plant drought tolerance and C₄ photosynthesis.

Researchers from Freiburg University developed an ultraflexible fiber-based 3D light delivery system for electrophysiology and optogenetic manipulation in freely moving animals. The system allows multiside modulation of neuronal activity combined with neuronal measurements.

The mechanosensitive ion channel PIEZO1 senses shear stress induced by collagen-fibre sliding in tendons, regulates their stiffness and influences jumping performance.

FG-Nups are disordered proteins in the nuclear pore complex (NPC) where they selectively control nuclear transport. Here authors build NPC-mimics based on DNA origami rings which attach a certain numbers of Nups to analyse those nanopores by cryoEM and conductance measurements.

A combination of fluorescence approaches that permit conformational changes of SNARE proteins to be visualized in different lipid environments reveals interactions underlying vesicle–membrane fusion.

Bacillus subtilis mutants lacking either of the biofilm extracellular matrix components, exopolysaccharide or the fibre protein TasA, can evolve compensatory mutations that act on the residual matrix component to restore biofilm formation.

The avian auditory papilla has many similarities to the mammalian cochlea but whether force generation by hair cells amplifies the travelling wave, as it does in mammals, remains unknown. Here the authors show that the chicken basilar papilla does not have a ‘cochlear amplifier’ and that sharp frequency tuning does not derive from mechanical vibrations.

Contact guidance on aligned substrates leads to directed cell migration through a poorly defined mechanism. Here the authors show that alignment of adhesion structures and F-actin generates anisotropic traction stress to drive directional migration, and cell-cell contact reduces force orientation and directional response.

The gondwanatherians were mammals known only from teeth and some jaw fragments that lived in the southern continents alongside dinosaurs; here the entire cranium of a bizarre and badger-sized fossil mammal from the Cretaceous of Madagascar shows that gondwanatherians were related to the better-known multituberculates, a long-lived and successful group of now-extinct rodent-like mammals.

Kirigami, the art of deploying flat sheets to create three-dimensional structures, relies often on complex folding processes that hinder industrial applications. Here, the authors develop a folding-wall kirigami pattern that deploys easily under tension, demonstrating its strength, stiffness, energy absorption, and interlocking properties.

The phase 3 GENESIS trial reports the superiority of the novel CXCR4 inhibitor motixafortide with G-CSF in mobilizing hematopoietic progenitor cells for autologous stem cell transplantation in multiple myeloma.

Cultured archaeal viruses, which so far all have double-stranded DNA genomes, come in all shapes and sizes, with the range of virion morphotypes surpassing that found in the viruses of the Bacteria. The authors present a unifying view of this fascinating viral group.

Mitral valve disease is a common cause of heart failure and death. In this Review from members of the Leducq Transatlantic Network, Levine and colleagues extensively summarize the molecular and cellular mechanisms underlying the dynamic changes that occur during progression of mitral valve disease, and indicate how improved understanding of the pathophysiology might lead to the discovery of novel therapeutic options.