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Showing 1–16 of 16 results
Advanced filters: Author: Paul Smolen Clear advanced filters

  • Rheumatoid arthritis is a chronic, inflammatory, autoimmune disease that primarily affects the joints. This Primer by Smolen et al. provides the latest insights into the epidemiology, genetics, pathophysiology, diagnostic approaches, clinical assessment and management of rheumatoid arthritis.

    • Josef S. Smolen
    • Daniel Aletaha
    • Kazuhiko Yamamoto
    Reviews
    Nature Reviews Disease Primers
    Volume: 4, P: 1-23

  • Evaluating the immune status of newborns helps recognition of those who are at higher risk for serious infectious diseases. Here authors identify lower, epigenetically inferred,

    neutrophil-to-lymphocyte ratios during the first week of life as risk factor for sepsis and provide insight into the underpinning epigenetic and transcriptional patterns.

    • David Martino
    • Nina Kresoje
    • Tobias R. Kollmann
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

    • Harry Pickering
    • Joanna Schaenman
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • The role of IgG glycosylation in the immune response has been studied, but less is known about IgM glycosylation. Here the authors characterize glycosylation of SARS-CoV-2 spike specific IgM and show that it correlates with COVID-19 severity and affects complement deposition.

    • Benjamin S. Haslund-Gourley
    • Kyra Woloszczuk
    • Mary Ann Comunale
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Colorectal cancer can lead to the development of peritoneal metastases, which are associated with worse disease outcome. Here, the authors characterize peritoneal metastases from 52 patients using RNA-seq and mutational sequencing and show a distinct molecular subtype.

    • Kristiaan J. Lenos
    • Sander Bach
    • Louis Vermeulen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Post-acute sequelae of SARS-CoV-2 (PASC) is still not well understood. Here the authors provide patient reported outcomes from 590 hospitalized COVID-19 patients and show association of PASC with higher respiratory SARS-CoV-2 load and circulating antibody titers, and in some an elevation in circulating fibroblast growth factor 21.

    • Al Ozonoff
    • Naresh Doni Jayavelu
    • Nadine Rouphael
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Multinucleated giant cells (MGCs) are important in the pathogenesis of various diseases. Here, the authors demonstrate that extracellular presence of the amino acid arginine is required for MGC formation and metabolism, suggesting a translational impact for strategies utilizing systemic arginine depletion in MGC-mediated diseases.

    • Julia S. Brunner
    • Loan Vulliard
    • Gernot Schabbauer
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • The authors use computational modeling to design an optimized learning protocol that takes into account the precise timing of molecular signaling cascades that are necessary for synaptic facilitation. This study demonstrates how learning and memory can be enhanced by the coordination of biochemical mechanisms and training protocols.

    • Yili Zhang
    • Rong-Yu Liu
    • John H Byrne
    Research
    Nature Neuroscience
    Volume: 15, P: 294-297

  • Drug development, underpinned by randomized controlled trials, has greatly advanced the the treatment of rheumatoid arthritis (RA). However, modern principles and goals of RA management raise new challenges and call into question the appropriateness of traditional trial designs. This Review discusses these designs and the associated challenges, and outlines opportunities that arise from innovative trial designs.

    • Maya H. Buch
    • Sue Pavitt
    • Paul Emery
    Reviews
    Nature Reviews Rheumatology
    Volume: 9, P: 183-194

  • The first week of life impacts health for all of life, but the mechanisms are little-understood. Here the authors extract multi-omic data from small volumes of blood to study the dynamic molecular changes during the first week of life, revealing a robust developmental trajectory common to different populations.

    • Amy H. Lee
    • Casey P. Shannon
    • Tobias R. Kollmann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Training involving repeated long inter-trial intervals — spaced training — leads to more robust memory formation for many types of learning than does training involving short or no intervals. This Review examines the learning theories and the molecular and cellular mechanisms that may account for the effectiveness of spaced training.

    • Paul Smolen
    • Yili Zhang
    • John H. Byrne
    Reviews
    Nature Reviews Neuroscience
    Volume: 17, P: 77-88