Nature Search

Diffusion in polymers

Paul Calvert
News & Views01 Sept 1977
Nature

Volume: 269, P: 290
Liquid crystalline suspensions of poly(tetrafluoroethylene) 'whiskers'

Thomas Folda
Heinz Hoffmann
Paul Smith
Research05 May 1988
Nature

Volume: 333, P: 55-56
Publisher Correction: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function

Sajjad Khani
Hande Topel
Jan-Wilhelm Kornfeld
Amendments and CorrectionsOpen Access04 Apr 2025
Nature Metabolism

Volume: 7, P: 855
T-bet⁺ B cells are activated by and control endogenous retroviruses through TLR-dependent mechanisms

Endogenous retroviruses (ERV) can induce immune responses and the control of these viruses uses immune mechanisms also involved in autoimmunity. Here, the authors characterize the control of ERVs in mice and show age-associated B cell control and nucleic acid sensing TLR pathway involvement.

Eileen Rauch
Timm Amendt
Philipp Yu
ResearchOpen Access09 Feb 2024
Nature Communications

Volume: 15, P: 1-19
Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

Steven A. Rosenberg
James C. Yang
Donald E. White
Research01 Mar 1998
Nature Medicine

Volume: 4, P: 321-327
Effect of a phorbol ester on a transformation-sensitive surface protein of chick fibroblasts

PETER M. BLUMBERG
PAUL E. DRIEDGER
PETER W. ROSSOW
Research02 Dec 1976
Nature

Volume: 264, P: 446-447
Mandibular Layering in Delphinapterus leucas and Age Determination

PAUL F. BRODIE
Research08 Mar 1969
Nature

Volume: 221, P: 956-958
Heavy fermions vs doped Mott physics in heterogeneous Ta-dichalcogenide bilayers

Recent experiments reported the Kondo effect in 1H/1T dichalcogenide hetero-bilayers. Crippa et al. re-examine this interpretation using ab initio calculations and dynamical mean-field theory demonstrating strong charge transfer sensitive to the interlayer separation, indicative of a doped Mott insulator regime.

Lorenzo Crippa
Hyeonhu Bae
Roser Valentí
ResearchOpen Access14 Feb 2024
Nature Communications

Volume: 15, P: 1-8
Correction: Publisher Correction: miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia

Zejuan Li
Hao Huang
Jianjun Chen
Amendments and Corrections10 Apr 2018
Nature Communications

Volume: 9, P: 1
Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting

Biglari et al. reveal subgroups of arcuate nucleus hypothalamic neurons that exhibit distinct molecular signatures and feeding-regulatory functions, thus uncovering new regulatory principles in body weight control.

Nasim Biglari
Isabella Gaziano
Jens C. Brüning
ResearchOpen Access17 May 2021
Nature Neuroscience

Volume: 24, P: 913-929
CRELD1 modulates homeostasis of the immune system in mice and humans

Within a human cohort, wide variation can occur with constitutively expressed proteins. Aschenbrenner and colleagues found that individuals with lower CRELD1 expression have decreased frequencies of naive CD4⁺ T cells. Mice with conditional Creld1 deficiency also exhibit a phenotype associated with immunological aging.

Lorenzo Bonaguro
Maren Köhne
Anna C. Aschenbrenner
Research09 Nov 2020
Nature Immunology

Volume: 21, P: 1517-1527
Cretaceous arachnid Chimerarachne yingi gen. et sp. nov. illuminates spider origins

A new Cretaceous arachnid fossil encased in Burmese amber sheds light on the evolution of spiders, as it preserves both primitive and derived features, suggestive of a basal Araneae position.

Bo Wang
Jason A. Dunlop
Xiaojie Lei
Research05 Feb 2018
Nature Ecology & Evolution

Volume: 2, P: 614-622
Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function

Truncated version of adenylyl cyclase 3 acts as a cold-induced rheostat during long-term brown adipose tissue activation.

Sajjad Khani
Hande Topel
Jan-Wilhelm Kornfeld
ResearchOpen Access29 Apr 2024
Nature Metabolism

Volume: 6, P: 1053-1075
Treatment of type 2 diabetes with the designer cytokine IC7Fc

The chimeric cytokine IC7Fc combines the beneficial effects of the cytokines IL-6 and CNTF on weight loss and metabolism in mice, with no obvious side effects in mice and non-human primates.

Maria Findeisen
Tamara L. Allen
Mark A. Febbraio
Research25 Sept 2019
Nature

Volume: 574, P: 63-68
Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease

Mucosal associated invariant T (MAIT) cells reside in barrier organs, but their contribution to inflammatory processes in the kidneys is not fully known. Here authors find by single cell RNA sequencing that among the different MAIT cell subtypes found at steady state, a population with MAIT17 signature is expanded in both human crescentic glomerulonephritis and its mouse model, and these cells may play protective role in the disease.

Ann-Christin Gnirck
Marie-Sophie Philipp
Jan-Eric Turner
ResearchOpen Access15 Nov 2023
Nature Communications

Volume: 14, P: 1-16
Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity

Tanycytic insulin receptors allow insulin access to the hypothalamic arcuate nucleus and are relevant for driving AgRP neuronal activity in response to feeding.

Marta Porniece Kumar
Anna Lena Cremer
Jens C. Brüning
ResearchOpen Access20 Dec 2021
Nature Metabolism

Volume: 3, P: 1662-1679
Formin-mediated nuclear actin at androgen receptors promotes transcription

Functional mutations identified in patients with androgen insensitivity syndrome, in the formin and actin nucleator DAAM2, uncover signal-regulated nuclear actin assembly at a steroid hormone receptor necessary for transcription.

Julian Knerr
Ralf Werner
Nadine C. Hornig
Research27 Mar 2023
Nature

Volume: 617, P: 616-622
Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity

The wake-active orexin system plays a central role in the dynamic regulation of glucose homeostasis. Here the authors report that inactivation of the orexin receptor type 1 or 2 in serotonergic neurons differentially regulate systemic glucose homeostasis in the context of diet induced obesity.

Xing Xiao
Gagik Yeghiazaryan
A. Christine Hausen
ResearchOpen Access02 Sept 2021
Nature Communications

Volume: 12, P: 1-20
miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia

HOX9AandMEIS1are key oncogenes in MLL-rearranged leukaemia. miRNA-196b is shown here to directly suppress their expression and delay MLL-fusion-mediated leukaemia, but to also cause an aggressive leukaemia phenotype when expressed ectopically, suggesting that it targets tumour suppressors as well.

Zejuan Li
Hao Huang
Jianjun Chen
Research21 Feb 2012
Nature Communications

Volume: 3, P: 1-12
Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia

ATM and TP53 mutations are associated with poor prognosis in chronic lymphocytic leukaemia (CLL). Here the authors generate mouse models of Tp53- and Atm-defective CLL mimicking the high-risk form of human disease and show that Atm-deficient CLL is sensitive to PARP1 inhibition.

Gero Knittel
Tim Rehkämper
H. Christian Reinhardt
ResearchOpen Access28 Jul 2017
Nature Communications

Volume: 8, P: 1-13
Changing local recombination patterns in Arabidopsis by CRISPR/Cas mediated chromosome engineering

The heterochromatic knob (hk4S) on Arabidopsis chromosome 4 prevents the recombination between accessions with and without hk4S. Here, via egg-cell specific expression of the Cas9 nuclease, the authors demonstrate targeted reversal of the 1.1 Mb long hk4S-inversion in Col-0 and restore the crossovers with Ler-1.

Carla Schmidt
Paul Fransz
Holger Puchta
ResearchOpen Access04 Sept 2020
Nature Communications

Volume: 11, P: 1-8
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

The enzymatic activity of caspase-8 controls apoptosis, necroptosis and pyroptosis, and prevents tissue damage during embryonic development and adulthood in mice.

Melanie Fritsch
Saskia D. Günther
Hamid Kashkar
Research20 Nov 2019
Nature

Volume: 575, P: 683-687
Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia

Ten-eleven translocation 1 (TET1) is a critical oncoprotein in AML. Here, the authors identify 2 compounds that target the binding of STAT3/5 specifically to the TET1 promoter, inhibiting its expression and AML cell viability.

Xi Jiang
Chao Hu
Jianjun Chen
ResearchOpen Access13 Dec 2017
Nature Communications

Volume: 8, P: 1-13
Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia

Xi Jiang
Chao Hu
Jianjun Chen
Amendments and CorrectionsOpen Access09 Feb 2018
Nature Communications

Volume: 9, P: 1
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

Steven Rosenberg and colleagues report that PD-1 is a biomarker of CD8⁺ T cells in the blood that recognize mutated neoantigens in melanoma.

Alena Gros
Maria R Parkhurst
Steven A Rosenberg
Research22 Feb 2016
Nature Medicine

Volume: 22, P: 433-438
Single and Transient Ca²⁺ Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion

Sybille Koehler
Sebastian Brähler
Paul T. Brinkkoetter
ResearchOpen Access19 Oct 2016
Scientific Reports

Volume: 6, P: 1-13
An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes

In an effort by several research groups, a genome-wide RNAi-based screen presents a list of validated genes involved in cilia assembly and maintenance, and reveals previously unidentified ciliopathy factors.

Gabrielle Wheway
Miriam Schmidts
Colin A. Johnson
Research13 Jul 2015
Nature Cell Biology

Volume: 17, P: 1074-1087
Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8⁺ T cell immunity

Lukas Flatz et al. have exploited the characteristics of the lymphocytic choriomeningitis virus (LCMV) to create a vaccine vector platform that elicits potent CD8⁺ T cell immunity. Using a recombinant, replication-defective LCMV, they show that these modified viral vectors target dendritic cells in vivo and trigger cytotoxic T lymphocyte responses that compare favorably with existing vectors. Other benefits include low global seroprevalence to LCMV and minimal interference of preexisting antibodies with vaccine efficacy.

Lukas Flatz
Ahmed N Hegazy
Daniel D Pinschewer
Research07 Feb 2010
Nature Medicine

Volume: 16, P: 339-345
Statistical learning of engineered topological phases in the kagome superlattice of AV₃Sb₅

Thomas Mertz
Paul Wunderlich
Roser Valentí
ResearchOpen Access11 Apr 2022
npj Computational Materials

Volume: 8, P: 1-6
Effects of Maternal Protein Malnutrition on Fetal Growth, Plasma Insulin-like Growth Factors, Insulin-like Growth Factor Binding Proteins, and Liver Insulin-like Growth Factor Gene Expression in the Rat

Séverin M Muaku
Véronique Beauloye
Dominique Maiter
Research01 Mar 1995
Pediatric Research

Volume: 37, P: 334-342
Interaction of viral proteins with host cell death machinery

David J Granville
Chris M Carthy
Bruce M McManus
Reviews03 Aug 1998
Cell Death & Differentiation

Volume: 5, P: 653-659
Advanced neurobiological tools to interrogate metabolism

This Review discusses the key principles and uses of engineered neurobiological tools, such as optogenetics and chemogenetics. The authors discuss examples of their use in the metabolism field and highlight important points to consider when choosing an experimental technique.

Paul Nicholas Mirabella
Henning Fenselau
Reviews06 Sept 2023
Nature Reviews Endocrinology

Volume: 19, P: 639-654

Search

Diffusion in polymers

Liquid crystalline suspensions of poly(tetrafluoroethylene) 'whiskers'

Publisher Correction: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function

T-bet⁺ B cells are activated by and control endogenous retroviruses through TLR-dependent mechanisms

Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

Effect of a phorbol ester on a transformation-sensitive surface protein of chick fibroblasts

Mandibular Layering in Delphinapterus leucas and Age Determination

Heavy fermions vs doped Mott physics in heterogeneous Ta-dichalcogenide bilayers

Correction: Publisher Correction: miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia

Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting

CRELD1 modulates homeostasis of the immune system in mice and humans

Cretaceous arachnid Chimerarachne yingi gen. et sp. nov. illuminates spider origins

Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function

Treatment of type 2 diabetes with the designer cytokine IC7Fc

Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease

Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity

Formin-mediated nuclear actin at androgen receptors promotes transcription

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity

miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia

Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia

Changing local recombination patterns in Arabidopsis by CRISPR/Cas mediated chromosome engineering

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia

Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

Single and Transient Ca²⁺ Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes

Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8⁺ T cell immunity

Statistical learning of engineered topological phases in the kagome superlattice of AV₃Sb₅

Effects of Maternal Protein Malnutrition on Fetal Growth, Plasma Insulin-like Growth Factors, Insulin-like Growth Factor Binding Proteins, and Liver Insulin-like Growth Factor Gene Expression in the Rat

Interaction of viral proteins with host cell death machinery

Advanced neurobiological tools to interrogate metabolism

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