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Asymmetric catalysis plays a crucial role in the synthesis of optically active organic molecules, but its application to stereogenic-at-metal complexes is more challenging. Here, the authors report the asymmetric synthesis of stereogenic-at-iridium complexes through kinetic resolution via a Pd-catalyzed Suzuki-Miyaura cross-coupling reaction.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

Understanding the atomic arrangement and binding nature of 2D materials with substrates is crucial to understand their properties and utilize their functions. Here, authors report that at high temperature graphene and α-Al₂O₃ substrate form a C-O-Al bond, having strong interactions, while interfacial structural relaxations of sapphire remain suppressed.

DNA-protein interactions form the fundamental structure of many pivotal biological processes. Here, authors propose ESM-DBP, which refines the DNA-binding protein sequence repertoire and ___domain-adaptive pretraining on general protein language models to predict DNA-binding protein-related tasks.

This study presents a comprehensive pipeline to profile transmembrane receptors involved in macrophage-driven inflammation in pancreatic islets during the onset of diabetes. The authors identify GPR132 as a mediator of macrophage-driven inflammation and find compounds that reduce inflammation and improve glycaemic control.

Dual-comb spectroscopy with time–frequency dissemination and high-power frequency combs enables sensing CO₂ and H₂O over a 113 km turbulent open-air path, with a sensing precision as high as 2 parts per million of CO₂.

How do cells regulate their migration speed and direction? Here, authors discover that keratocyte cells can reversibly switch between different migration modes, by changing the 3D lamellipodium shape and intracellular diffusion.

Constructing crossmodal in-sensor processing system based on high-performance flexible devices is important for the development of wearable human-machine interfaces. This work reports a bio-inspired spiking sensory neuron based on a flexible VO2 memristor and demonstrates a crossmodal in-sensor encoding and computing system.

This study of Chinese endometrioid endometrial carcinomas describes the proteogenomic differences between early-onset and late-onset tumors, finding that SIGLEC10 mutation may contribute to tumorigenesis and progestin resistance in early cases.

During stomatal opening and closing, the guard cell microtubule cytoskeleton is reorganised. Here the authors show that the E3 ubiquitin ligase MREL57 targets the microtubule stabilizing protein WDL7 to promote microtubule disassembly during ABA-induced stomatal closure.

The emergence of moiré superlattices in twisted two-dimensional halide perovskites has been reported, revealing the emergence of localized bright excitons with enhanced emissions and trapped charge carriers.

Carrier recombination limits the power conversion efficiency of perovskite solar cells. Here the authors construct a planar p–n homojunction perovskite solar cell to promote the oriented transport of carriers and reduce recombination, thus enabling power conversion efficiency of 21.3%.

Editing of a rice gene that has a role in phospholipid synthesis has endowed rice plants with broad-spectrum resistance to disease, including protection from common bacterial and fungal pathogens, without decreasing the yield.

TIP60-mediated crotonylation of the microtubule plus-end tracking protein EB1 at Lys66 regulates attachment of astral microtubules to the lateral cell cortex and spindle positioning.

Using a human forebrain organoid model of fragile X syndrome, Kang et al. reveal a critical role of FMRP in human brain development and identify a large number of human-specific mRNAs that could be regulated by FMRP.

Existing optogenetic methods to induce calcium mobilisation lack selectivity and specificity. Here, the authors design and engineer a single-component light-operated calcium channel to provide optical control over calcium signals and calcium-dependent physiological responses: LOCa.

Controlling the structural transformations of metal clusters is challenging. Here, the authors synthesize a silver nanocluster and study the structural changes that take place upon reaction with bipyridine derivatives.

CsPbI_3–xBr_x solar cells, which undergo temperature- and moisture-driven reversible transitions between a non-perovskite transparent phase and a perovskite light-absorbing phase, are used as thermochromic photovoltaic devices integrated in windows.

A one-step spin-coating approach to fabricate scalable epitaxial heterodimensional tin perovskite thin films results in near-infrared tin perovskite LEDs with a peak external quantum efficiency of 11.6%.

A manifold-preserving feature selection method was developed for single-cell data analysis, which selects non-redundant features to help detect rare cell populations, design follow-up studies and create targeted panels.

The COVID-19 pandemic has stopped many human activities, which has had significant impact on emissions of greenhouse gases. Here, the authors present daily estimates of country-level CO₂ emissions for different economic sectors and show that there has been a 8.8% decrease in global CO2 emissions in the first half of 2020.

The genetic changes that occur in late stage metastatic melanoma are not well delineated. Here, the authors use rapid autopsy samples from metastatic melanoma patients and show that the late stage in the disease is characterised by whole genome doubling and aneuploidy.

Fungal cell walls release β-1,3-glucan fragments that trigger plant immunity. Here, the authors show that a glucanase (Ebg1) of the blast fungus Magnaporthe oryzae suppresses plant immunity by hydrolyzing β-1,3-glucan. At the same time, Ebg1 induces plant immune responses that are dampened by a fungal protein that interacts with Ebg1.

Differentiation of embryonic stem cells (ESCs) into neural lineages involves epigenetic changes. Here the authors show that transient histone deacetylation promotes the transition from epiblast stem cells to neural progenitors during mouse ESC differentiation and show that this effect is partly mediated by the restriction of Nodal signalling by histone deacetylase 1.

A polymeric protein complex consisting of a newly identified magnetoreceptor protein and known magnetoreception-related photoreceptor cryptochromes exhibits spontaneous alignment in magnetic fields.

Millions of Chinese smallholder farmers were persuaded to adopt enhanced management practices, which led to a greater yield, reduced nitrogen fertilizer use and improved environmental performance throughout China.

Dongfeng Gu and colleagues report a genome-wide association study for coronary artery disease in Han Chinese individuals. They identify four loci newly associated with coronary artery disease.