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Liver X receptor unlinks intestinal regeneration and tumorigenesis

Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.

Srustidhar Das
S. Martina Parigi
Eduardo J. Villablanca
ResearchOpen Access20 Nov 2024
Nature

Volume: 637, P: 1198-1206
Molecular and functional heterogeneity of IL-10-producing CD4⁺ T cells

Tr1 cells are considered an immunosuppressive CD4 T cell population producing IL-10. Here the authors show that IL-10 is insufficient for Tr1 immunosuppression, define surface markers and transcriptional program of the immunosuppressive subset within Tr1, and reveal its deficiency in patients with IBD.

Leonie Brockmann
Shiwa Soukou
Samuel Huber
ResearchOpen Access21 Dec 2018
Nature Communications

Volume: 9, P: 1-14
Harnessing the reverse cholesterol transport pathway to favor differentiation of monocyte-derived APCs and antitumor responses

Laura Raccosta
Maura Marinozzi
Vincenzo Russo
ResearchOpen Access15 Feb 2023
Cell Death & Disease

Volume: 14, P: 1-21
Loss of liver X receptor β in astrocytes leads to anxiety-like behaviors via regulating synaptic transmission in the medial prefrontal cortex in mice

Xin Li
Hongyu Zhong
Xiaotang Fan
Research07 May 2021
Molecular Psychiatry

Volume: 26, P: 6380-6393
Liver X receptor regulates Th17 and RORγt⁺ Treg cells by distinct mechanisms

Sara M. Parigi
Srustidhar Das
Eduardo J. Villablanca
Research17 Jul 2020
Mucosal Immunology

Volume: 14, P: 411-419