Nature Search

Self-organizing glycolytic waves tune cellular metabolic states and fuel cancer progression

Glycolytic enzymes form self-organized traveling waves at the cell membrane/cortex, boosting local ATP production and cell movement. Cancer cells with intense waves rely more on glycolysis for energy, potentially explaining the Warburg effect.

Huiwang Zhan
Dhiman Sankar Pal
Peter N. Devreotes
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-19
Different Ly antigen phenotypes of in vitro induced helper and suppressor cells

MARC FELDMANN
PETER C. L. BEVERLEY
SIRKKA KONTIAINEN
Research01 Dec 1975
Nature

Volume: 258, P: 614-616
Natural selection in wildflower books

Peter D. Moore
Books & Arts07 Dec 1978
Nature

Volume: 276, P: 650-651
Witnessing the onset of reionization through Lyman-α emission at redshift 13

Spectroscopy from the JWST Advanced Deep Extragalactic Survey of a galaxy at redshift 13 shows a singular, bright emission line identified as Lyman-α, suggesting the onset of reionization only 330 Myr after the Big Bang.

Joris Witstok
Peter Jakobsen
Yongda Zhu
ResearchOpen Access26 Mar 2025
Nature

Volume: 639, P: 897-901
An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies

New in vitro data suggest that the new SARS-CoV-2 Omicron variant is likely to escape neutralization by most therapeutic antibodies currently available.

Laura A. VanBlargan
John M. Errico
Michael S. Diamond
Research19 Jan 2022
Nature Medicine

Volume: 28, P: 490-495
Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis

Anti-NMDA receptor encephalitis is a severe brain disorder caused by autoantibodies that trigger NMDA receptor loss. Here, the authors show that ART5803, a monovalent antibody, blocks this process and restores function in cell and primate models.

Atsuo Kanno
Takuya Kito
Mitsuyuki Matsumoto
ResearchOpen Access17 Jun 2025
Nature Communications

Volume: 16, P: 1-22
SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers

Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

Jin Zhou
Austin Hepperla
Qing Zhang
ResearchOpen Access05 Jun 2025
Nature Communications

Volume: 16, P: 1-19
Earth-mass planets with He atmospheres in the habitable zone of Sun-like stars

Simulations of long-term atmospheric evolution show that rocky planets with Earth-like masses in the classical habitable zone of Sun-like stars can retain thick He-dominated primordial atmospheres.

Helmut Lammer
Manuel Scherf
Peter Woitke
ResearchOpen Access12 Jun 2025
Nature Astronomy

P: 1-9
Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptors

Yoshihiro Hayakawa
Stuart P Berzins
Mark J Smyth
Research02 May 2004
Nature Immunology

Volume: 5, P: 590-596
Clonal dynamics and somatic evolution of haematopoiesis in mouse

Isolating and studying haematopoietic stem cells in young and aged mice demonstrates evolutionary processes related to blood production and provides a framework for interpreting future work using laboratory mice to study stem cell ageing.

Chiraag D. Kapadia
Nicholas Williams
Jyoti Nangalia
ResearchOpen Access05 Mar 2025
Nature

Volume: 641, P: 681-689
Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12

The epigenetic and transcriptional roles of Nucleoporin 98 (NUP98) fusion oncoproteins in driving pediatric acute myeloid leukemia (AML) remain to be explored. Here, the authors identify a core set of genes regulated by NUP98::KDM5A and suggest CDK12 as a potential therapeutic vulnerability.

Selina Troester
Thomas Eder
Florian Grebien
ResearchOpen Access19 May 2025
Nature Communications

Volume: 16, P: 1-21
Myocardial infarction accelerates atherosclerosis

Myocardial infarction accelerates atherosclerosis through activation of the sympathetic nervous system, and the consequent release of haematopoietic stem and progenitor cells.

Partha Dutta
Gabriel Courties
Matthias Nahrendorf
Research27 Jun 2012
Nature

Volume: 487, P: 325-329
Therapeutic siRNA silencing in inflammatory monocytes in mice

In vivo silencing in specific cell types remains the main obstacle for therapeutic applications of siRNAs. Leuschner et al. now show that an optimized lipid nanoparticle delivers siRNA to inflammatory monocytes in mice and, when transporting CCR2 siRNA, has therapeutic effects in cardiovascular disease, cancer and transplant rejection.

Florian Leuschner
Partha Dutta
Matthias Nahrendorf
Research09 Oct 2011
Nature Biotechnology

Volume: 29, P: 1005-1010
The Rac–RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI

Klaus Scheffzek
Ilona Stephan
Peter Gierschik
Research01 Feb 2000
Nature Structural Biology

Volume: 7, P: 122-126
Tuberculosis vaccine strain Mycobacterium bovis BCG Russia is a natural recA mutant

Peter Keller
Erik Boettger
Peter Sander
ResearchOpen Access07 Feb 2008
Nature Precedings

P: 1
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

Andrew H. Sinclair
Philippe Berta
Peter N. Goodfellow
Research19 Jul 1990
Nature

Volume: 346, P: 240-244
cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

Christer Betsholtz
Ann Johnsson
James Scott
Research24 Apr 1986
Nature

Volume: 320, P: 695-699
Topology of signal recognition particle receptor in endoplasmic reticulum membrane

Leander Lauffer
Pablo D. Garcia
Peter Walter
Research28 Nov 1985
Nature

Volume: 318, P: 334-338
Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas

A hydrogel-based modular lymphoma organoid identifies how lymphoid microenvironment cues dampen the effect of MALT1 inhibitors and informs effective combination therapies to rescue the treatment response

Shivem B. Shah
Christopher R. Carlson
Ankur Singh
Research16 Mar 2023
Nature Materials

Volume: 22, P: 511-523
Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release

Nociceptin is an opioid peptide regulating important brain functions, including motivation and 2stress responses. Here, the authors develop and validate a genetically encoded sensor as a tool for high-resolution detection of endogenous nociceptin in living animals.

Xuehan Zhou
Carrie Stine
Tommaso Patriarchi
ResearchOpen Access25 Jun 2024
Nature Communications

Volume: 15, P: 1-20
Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin

Kara S Giddings
Ji Zhao
Rodney K Tweten
Research14 Nov 2004
Nature Structural & Molecular Biology

Volume: 11, P: 1173-1178
Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal ___location

Brigitte Royer-Pokora
Louis M. Kunkel
Stuart H. Orkin
Research03 Jul 1986
Nature

Volume: 322, P: 32-38
Synthesis of Adenosine Triphosphate by a Protonmotive Force in Rat Liver Mitochondria

R. A. REID
JENNIFER MOYLE
PETER MITCHELL
Research15 Oct 1966
Nature

Volume: 212, P: 257-258
Modelling predicts that heat stress and not drought will limit wheat yield in Europe

Mikhail Semenov
Peter Shewry
ResearchOpen Access07 Apr 2010
Nature Precedings

P: 1
Single-cell RNA sequencing dissects the immunosuppressive signatures in Helicobacter pylori-infected human gastric ecosystem

Helicobacter pylori (H. pylori) establishes chronic infection in human, but the underlying mechanistic insights are lacking. Here the authors use single cell RNA and TCR sequencing to profile peripheral blood and mucosal cells from infected patients to report alterations in macrophage differentiation and T cell gene signature that may contribute to persisting H. pylori infection.

Wei Hu
Ze Min Chen
Wei Gong
ResearchOpen Access25 Apr 2025
Nature Communications

Volume: 16, P: 1-16
BBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinoma

Metabolic dysregulation in the development of clear cell renal cell carcinoma (ccRCC) remains to be understood. Here the authors identify that a carnitine synthesis enzyme BBOX1, which inhibits TBK1-mTORC1 signaling and glycolysis, is often lost in ccRCC.

Chengheng Liao
Lianxin Hu
Qing Zhang
ResearchOpen Access11 Feb 2025
Nature Communications

Volume: 16, P: 1-18
Malaria-driven adaptation of MHC class I in wild bonobo populations

A variant of MHC class I is protective against severe malaria disease and enriched in affected African populations. Here, Wroblewski et al., characterise the consequences of malaria infection in wild bonobo populations showing that the presence of malaria drives a similar evolution in immune genes.

Emily E. Wroblewski
Lisbeth A. Guethlein
Peter Parham
ResearchOpen Access23 Feb 2023
Nature Communications

Volume: 14, P: 1-11
The enigma of the natural killer cell

Jenny E. Gumperz
Peter Parham
Reviews16 Nov 1995
Nature

Volume: 378, P: 245-248
Sjögren–Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene

Vincenzo De Laurenzi
Geraldine R. Rogers
William B. Rizzo
Research01 Jan 1996
Nature Genetics

Volume: 12, P: 52-57
Sleep modulates haematopoiesis and protects against atherosclerosis

The fragmentation of sleep in Apoe^−/− mice induces monocytosis and accelerated atherosclerosis due to a reduction in hypocretin that otherwise restricts bone marrow CSF1 availability.

Cameron S. McAlpine
Máté G. Kiss
Filip K. Swirski
Research13 Feb 2019
Nature

Volume: 566, P: 383-387
MCL‑1 safeguards activated hair follicle stem cells to enable adult hair regeneration

Here the authors unveil the essential role of MCL-1 for adult hair follicle regeneration and inhibition of proliferation stress-induced apoptosis in mice. They also identify a P53/MCL-1/BAK axis balancing proliferation and death of activated hair follicle stem cells to ensure proper hair growth.

Hui San Chin
Jinming Cheng
Nai Yang Fu
ResearchOpen Access22 Mar 2025
Nature Communications

Volume: 16, P: 1-20
Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1–HER3 signaling

Trumpp and colleagues develop a method to obtain long-term circulating tumor cell-derived organoids from individuals with metastatic breast cancer and identify the neuregulin 1–HER3 axis as important for organoid growth and a promising therapeutic target.

Roberto Würth
Elisa Donato
Andreas Trumpp
ResearchOpen Access03 Jan 2025
Nature Cancer

Volume: 6, P: 67-85
Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7

The SARS-CoV-2 variant B.1.1.7 can be neutralized by convalescent sera or sera from vaccinated individuals, whereas the B.1.351 variant is resistant to neutralization by these sera and by several monoclonal antibodies that are in clinical use.

Pengfei Wang
Manoj S. Nair
David D. Ho
Research08 Mar 2021
Nature

Volume: 593, P: 130-135
Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA

Michael Comb
Peter H. Seeburg
Edward Herbert
Research25 Feb 1982
Nature

Volume: 295, P: 663-666
Unsupervised learning of aging principles from longitudinal data

Biomarkers of age and frailty may aid in understanding the aging process, predicting lifespan or health span and in assessing the effects of anti-aging interventions. Here, the authors show that combining physics-based models and deep learning may enhance understanding of aging from big biomedical data, observe effects of anti-aging interventions in laboratory animals, and discover signatures of longevity.

Konstantin Avchaciov
Marina P. Antoch
Peter O. Fedichev
ResearchOpen Access01 Nov 2022
Nature Communications

Volume: 13, P: 1-14
Helioseismic inference of the solar radiative opacity

Opacities are considered to be the source of the disagreement between theoretical solar models and helioseismic data. Here, the authors show solar opacity profiles derived from seismic inferences, which differs from theoretical values used in the solar models.

Gaël Buldgen
Jean-Christophe Pain
David P. Kilcrease
ResearchOpen Access27 Jan 2025
Nature Communications

Volume: 16, P: 1-14
Ablation of cDC2 development by triple mutations within the Zeb2 enhancer

The transcription factor NFIL3 acts antagonistically to C/EBP proteins by binding the Zeb2 enhancer to prevent Zeb2 expression and the development of the conventional type 2 dendritic cell lineage.

Tian-Tian Liu
Sunkyung Kim
Kenneth M. Murphy
Research22 Jun 2022
Nature

Volume: 607, P: 142-148
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

Damaged erythrocytes accumulate in various pathological conditions, such as hemolytic anemia, anemia of inflammation, and sickle cell disease. In mice challenged with damaged erythorcytes, a monocyte subset migrates to the liver (but not to the spleen), and this subset differentiates into a transient macrophage population that removes the damaged erythrocytes, thus preventing organ damage.

Igor Theurl
Ingo Hilgendorf
Filip K Swirski
Research18 Jul 2016
Nature Medicine

Volume: 22, P: 945-951
Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity

Zhang and colleagues identify a role for cell death by glutathione peroxidase 4 (GPX4)-regulated ferroptosis in neutrophils from patients with systemic lupus erythematosus, which is triggered by type I interferons and autoreactive antibodies and contributes to lupus pathogenesis. Inhibiting accumulation of oxidative mediators by GPX4 suppresses ferroptosis.

Pengchong Li
Mengdi Jiang
Xuan Zhang
Research12 Aug 2021
Nature Immunology

Volume: 22, P: 1107-1117
Impact of pulmonary African trypanosomes on the immunology and function of the lung

A number of human African trypanosomiasis, or sleeping sickness, patients suffer from respiratory symptoms commonly attributed to cardiac insufficiency. Here, the authors characterise the role of pulmonary Trypanosoma brucei in respiratory infection.

Dorien Mabille
Laura Dirkx
Guy Caljon
ResearchOpen Access18 Nov 2022
Nature Communications

Volume: 13, P: 1-18
PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

Ajay Chawla
Yaacov Barak
Ronald M. Evans
Research01 Jan 2001
Nature Medicine

Volume: 7, P: 48-52
Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

Peter J. Peters
Jacques J. Neefjes
Hans J. Geuze
Research21 Feb 1991
Nature

Volume: 349, P: 669-676
Identification of direct connections between the dura and the brain

Arachnoid cuff exit points create openings in the arachnoid barrier enabling the drainage of cerebrospinal fluid and exchange of molecules and cells between the dura and the subarachnoid space, therefore physically connecting the brain and the dura.

Leon C. D. Smyth
Di Xu
Jonathan Kipnis
Research07 Feb 2024
Nature

Volume: 627, P: 165-173
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

Xiao Jian Sun
Paul Rothenberg
Morris F White
Research04 Jul 1991
Nature

Volume: 352, P: 73-77
The drug resistance-related protein LRP is the human major vault protein

George L. Scheffer
Peter L.J. Wijngaard
Rik J. Scheper
Research01 Jun 1995
Nature Medicine

Volume: 1, P: 578-582
Nonsense suppressors of Saccharomyces cerevisiae can be generated by mutation of the tyrosine tRNA anticodon

Peter W. Piper
Marilyn Wasserstein
Fred Sherman
Research26 Aug 1976
Nature

Volume: 262, P: 757-761
Mutations in the PAX3 gene causing Waardenburg syndrome type 1 and type 2

May Tassabehji
Andrew P. Read
Tom Strachan
Research01 Jan 1993
Nature Genetics

Volume: 3, P: 26-30
A third native one-disulphide intermediate in the folding of bovine pancreatic trypsin inhibitor

Michal Dadlez
Peter S. Kim
Research01 Aug 1995
Nature Structural Biology

Volume: 2, P: 674-679
Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone

David V. Goeddel
Herbert L. Heyneker
Peter H. Seeburg
Research01 Oct 1979
Nature

Volume: 281, P: 544-548
Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells

The beneficial effects of exercise on cardiovascular disease are linked to decreased inflammation through crosstalk between adipose tissue and hematopoietic progenitor cells in the bone marrow.

Vanessa Frodermann
David Rohde
Matthias Nahrendorf
Research07 Nov 2019
Nature Medicine

Volume: 25, P: 1761-1771

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