Nature Search

Extreme summer heat and drought lead to early fruit abortion in European beech

Anita Nussbaumer
Katrin Meusburger
Anne Thimonier
ResearchOpen Access24 Mar 2020
Scientific Reports

Volume: 10, P: 1-11
Small-molecule inhibitors of human mitochondrial DNA transcription

Inhibitors of mitochondrial transcription that target human mitochondrial RNA polymerase provide a chemical biology tool for studying the role of mitochondrial DNA expression in a wide range of pathologies.

Nina A. Bonekamp
Bradley Peter
Nils-Göran Larsson
Research16 Dec 2020
Nature

Volume: 588, P: 712-716
PD-1 defines a distinct, functional, tissue-adapted state in Vδ1⁺ T cells with implications for cancer immunotherapy

Davies et al. show that skin PD-1⁺Vδ1⁺ cells show a transcriptional program of tissue residence and self-renewal, are functionally distinct from colocalized PD-1⁺CD8⁺ T cells and retain effector function that is derepressed by checkpoint blockade.

Daniel Davies
Shraddha Kamdar
Yin Wu
ResearchOpen Access03 Jan 2024
Nature Cancer

Volume: 5, P: 420-432
The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness

Hayday and colleagues show that the responsiveness of mouse and human γδ IELs to Btnl or BTNL proteins is mediated by germline-encoded motifs within the cognate TCR V_γ chains, while V_γ chain motifs generated by somatic gene rearrangement remain available for nominal antigen binding.

Daisy Melandri
Iva Zlatareva
Adrian C. Hayday
Research12 Nov 2018
Nature Immunology

Volume: 19, P: 1352-1365
Identification of pyrazolopyridazinones as PDEδ inhibitors

PDEδ is a widely expressed factor that sustains the spatial organization and signalling of Ras family proteins. Here the authors describe the activity of Deltazinone 1, a new highly selective PDEδ inhibitor of KRAS-dependent cancer cell growth with low cytotoxic side effects.

Björn Papke
Sandip Murarka
Philippe I.H. Bastiaens
ResearchOpen Access20 Apr 2016
Nature Communications

Volume: 7, P: 1-9
Biological data derived from European weather radars

Peter Desmet
Judy Shamoun-Baranes
Cecilia Nilsson
ResearchOpen Access28 Feb 2025
Scientific Data

Volume: 12, P: 1-11
IMI European Lead Factory — democratizing access to high-throughput screening

The European Lead Factory combines assets and experience from major pharma with innovation and agility of academia and SMEs in a collaborative platform to expand access to high-throughput screening. With many successes heading towards the clinic, the organization is broadening its approach to screening and partnering.

Philip S. Jones
Sylviane Boucharens
Jon S. B. de Vlieger
Comments & Opinion14 Dec 2021
Nature Reviews Drug Discovery

Volume: 21, P: 245-246
A physical, genetic and functional sequence assembly of the barley genome

An integrated high-resolution genetic, physical and shotgun sequence assembly of the barley genome, one of the earliest domesticated and most important crops, is described; it will provide a platform for genome-assisted research and future crop improvement.

Klaus F. X. Mayer
Robbie Waugh
Nils Stein
ResearchOpen Access17 Oct 2012
Nature

Volume: 491, P: 711-716
Na⁺ entry through heteromeric TRPC4/C1 channels mediates (−)Englerin A-induced cytotoxicity in synovial sarcoma cells

Katsuhiko Muraki
Kaori Ohnishi
David J. Beech
ResearchOpen Access05 Dec 2017
Scientific Reports

Volume: 7, P: 1-12

Search

Filter By:

Search

Quick links