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Showing 1–2 of 2 results
Advanced filters: Author: Petr Rathner Clear advanced filters
  • Stormorken syndrome is associated with the R304W mutation in STIM1, which is a Calcium sensor in the endoplasmic reticulum. Here authors use FRET and electrophysiology to show that R304W induces STIM1 conformational extension by a dual mechanism resulting in constitutive activation of Ca2+ channels.

    • Marc Fahrner
    • Michael Stadlbauer
    • Christoph Romanin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12
  • The helical bundle structure of the CC1 ___domain of STIM1 of the store-activated calcium channel CRAC is crucial to maintaining the channel resting state, and helix–helix interactions can be manipulated to normalize a disease-linked STIM1 mutant.

    • Petr Rathner
    • Marc Fahrner
    • Norbert Müller
    Research
    Nature Chemical Biology
    Volume: 17, P: 196-204