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Showing 1–4 of 4 results

Advanced filters: Author: Philippa Meiser Clear advanced filters

A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection

A liver-intrinsic mechanism is presented that suppresses effective anti-hepatitis virus B responses in mice and humans by rendering virus-specific CD8 T cells refractory to activation causing loss of effector functions.

Miriam Bosch
Nina Kallin
Percy A. Knolle
ResearchOpen Access10 Jul 2024
Nature

Volume: 631, P: 867-875
PGE₂ limits effector expansion of tumour-infiltrating stem-like CD8⁺ T cells

Tumour-derived prostaglandin E₂, signaling through its receptors EP₂ and EP₄, is shown to restrain the responses of tumour-infiltrating stem-like TCF1⁺CD8⁺ T lymphocytes, and modulation of T cell EP₂ and EP₄ can restore anticancer immunity.

Sebastian B. Lacher
Janina Dörr
Jan P. Böttcher
ResearchOpen Access24 Apr 2024
Nature

Volume: 629, P: 417-425
Author Correction: Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH

Michael Dudek
Dominik Pfister
Percy A. Knolle
Amendments and Corrections10 May 2021
Nature

Volume: 593, P: E14
Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH

Liver resident CD8 T cells have an essential role in immunopathology in a mouse model of nonalcoholic steatohepatitis, by becoming auto-aggressive following sequential transcriptional and metabolic activation steps .

Michael Dudek
Dominik Pfister
Percy A. Knolle
Research24 Mar 2021
Nature

Volume: 592, P: 444-449

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A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection

PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells

Author Correction: Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

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PGE₂ limits effector expansion of tumour-infiltrating stem-like CD8⁺ T cells

Author Correction: Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH

Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH