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Advanced filters: Author: Philippe Orcel Clear advanced filters

Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor

The functional consequence of G protein-coupled receptor oligomerization remains debated. Here the authors show that platelet-activating factor receptor oligomerization enhances G protein coupling, and restrains β-arrestin recruitment and internalization.

Junke Liu
Hengmin Tang
Jianfeng Liu
ResearchOpen Access26 Oct 2022
Nature Communications

Volume: 13, P: 1-16
Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial

In the LUMINA-1 trial for fibrodysplasia ossificans progressiva, garetosmab, an activin A monoclonal antibody, did not lead to significant changes in heterotopic ossification lesion activity in pre-existing lesions in period 1. Garetosmab prevented the formation of new lesions in both periods 1 and 2.

Maja Di Rocco
Eduardo Forleo-Neto
Frederick S. Kaplan
ResearchOpen Access28 Sept 2023
Nature Medicine

Volume: 29, P: 2615-2624
Lumbar spinal stenosis and disc alterations affect the upper lumbar spine in adults with achondroplasia

Thomas Huet
Martine Cohen-Solal
Johann Beaudreuil
ResearchOpen Access13 Mar 2020
Scientific Reports

Volume: 10, P: 1-7
Increase In Il-31 Serum Levels Is Associated With Reduced Structural Damage In Early Axial Spondyloarthritis

Nicolas Rosine
Adrien Etcheto
Corinne Miceli-Richard
ResearchOpen Access16 May 2018
Scientific Reports

Volume: 8, P: 1-10

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