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Maintaining proper reactive oxygen species (ROS) balance is critical for cellular and individual health, yet its dynamic nature encumbers monitoring and assessment. Here the authors propose a platform using mass cytometry-based detection, termed SN-ROP, to identify distinct ROS profiles associated with specific immune cell functions and disease states.

Negative regulator of thermotolerance 1 (NAT1) is identified as a negative regulator of thermotolerance in rice through the NAT1–bHLH110–CER1/CER1L module. Modifying NAT1 by targeted gene editing increases wax deposition and enhances thermotolerance in rice.

In this work, authors study a molecular signature in STING protein that is critical for distinguishing activation from inhibition and demonstrates therapeutic potential in correcting STING-related mutations in autoimmune conditions like STING-Associated Vasculopathy with onset in Infancy (SAVI).

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

DeepRETStroke is a deep learning system using retinal photographs to detect silent brain infarction and predict future stroke events.

Here, the authors show that Lactobacillus acidophilus supplementation enhances oncolytic virus VSVΔ51 effect through restoring gut barrier integrity and microbiota homeostasis in mice.

Designing efficient redox mediators for solar-to-fuel conversion is a challenge, requiring multi-electron transfer, suitable redox potential, and stable pH buffering. Here, the authors report polyoxometalate-based mediators with defect engineering, enabling reliable solar-to-fuel conversion.

The reason of mature tertiary lymphoid structures (mTLS) correlates with better prognosis and responses to immune checkpoint blockade (ICB) remains incompletely understood. By employing sequencing and spatial transcriptomics strategies, the authors show that mTLS are enriched with progenitor exhausted CD4⁺ T cells that promotes activation of T and B cells.

Electrosynthesis of acetate from CO using renewable electricity faces low selectivity. Here, the authors report a cerium single atom modulated copper catalyst, where cerium atoms tailor the interfacial water structure, enabling highly selective CO-to-acetate conversion under pulsed electrolysis.

One challenge for spin-based electronics is the controlled and reliable switching of magnetization without magnetic fields. Here, Liu et al investigate a variety of compositions of CoPt, and determine the specific composition to maximize switching performance, potentially simplifying device design.

Ancient DNA can reveal evolutionary and demographic history of a region. Here, the authors analyze ancient human DNA from ShanDong, China to reveal two waves of gene flow from Yellow River populations in the DaWenKou (6-4 kBP) and early dynastic (3.5-1.5 kBP) periods.

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

UDA-seq incorporates a post-indexing step to enhance the throughput of droplet-based single-cell multimodal sequencing, enabling efficient large-scale single-cell analysis.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Multimodal large language models (MLLMs) hold promise for a range of medical applications. Here, the authors use MLLMs for 3D brain CT radiology report generation, demonstrating that combining anatomy-aware model fine-tuning with robust evaluation metrics establishes a comprehensive and effective framework.

Efficient catalysts for seawater electrolysis are crucial for sustainable hydrogen production but struggle with slow kinetics and low durability. Here, the authors report a molybdenum nitride catalyst that in situ generates ammonium groups, enhancing both performance and stability in natural seawater.

An isotonic buffer that dampens cytosolic cGAS–DNA interactions improves the viability of genome-engineered T cells transfected by electroporation.

How obesity causes cardiac dysfunction is not fully understood. Here, the authors show that a high fat diet inhibits the activity of RabGAP AS160 in the heart, causing pathological metabolic remodeling and altering calcium signaling.

The relationship between tissue-specific DNA methylation and cancer risk remains to be elucidated. Here, the authors predict DNA methylation at CpG sites for seven cancer types and investigate how these influence cancer risk.

Intrinsic toughening in two-dimensional transition metal dichalcogenides can be achieved simply by twisting the layers. This twisting promotes cross-layer healing and grain boundary formation, which shield fracture tips from stress concentration.

Oxidative stress contributes significantly to postmenopausal osteoporosis by impairing osteoblast function, but its precise mechanisms remain unclear. Here, the authors show that estrogen deficiency reduces GPX4 expression, leading to phospholipid peroxidation that impairs osteoblastogenesis, while GPX4 activators including 6- and 8-Gingerols can mitigate these effects.

A variant in the IFITM3gene increases the risk of severe influenza, but homozygosity is rare in Caucasians. The authors show that the variant gene is homozygous in 25% of healthy Chinese people, and 69% of those with severe pandemic influenza, suggesting that this gene influences the epidemiology of influenza in South-East Asia.

Natural materials with highly oriented and heterogeneous structures often have favorable materials properties, but such structures are challenging to replicate in artificial materials. Here, the authors report the development of hierarchically aligned heterogeneous hydrogels with toughness and strength.

Multi-ancestry fine-mapping of breast cancer susceptibility regions identifies candidate causal variants and prioritizes likely effector genes supported by functional genomic evidence.

Diarrhoea is a major cause of morbidity and mortality in China. Here, the authors present results from a large sentinel surveillance scheme from 217 hospitals in all 31 provinces in mainland China, including ~150,000 patients with acute diarrhoea and covering years 2009-2018.

Bacteria of the genus Streptomyces have complex life cycles involving cellular differentiation and multicellular structures that have never been observed in archaea. Here, the authors show that several halophilic archaea display a life cycle resembling that of Streptomyces bacteria, undergoing cellular differentiation into mycelia and spores.

The development of cost-effective, sustainable, and efficient catalysts for liquid organic hydrogen carrier systems is a significant goal. Herein, authors present a system based on manganese catalysis with a theoretical H₂ capacity of 5.3 wt% and high selectivity for the dehydrogenation reaction.

Electronic components made from two-dimensional MoTe₂ can be chemically synthesized and integrated in a single step, creating devices in which each component in the active layer is connected via covalent bonds.

Pancreatic Spint1 disruption causes glucose intolerance, reduced islet size, and decreased insulin synthesis and secretion. SPINT1 regulates HEPSIN’s modification of GLP1R/MAFA activation, vital for glucose control by β cells, linking it to diabetes.

The RNA helicase DHX9 is important for genome stability. Here the authors reveal that SUMOylation of DHX9 enhances its interaction with multiple proteins involved in the removal of harmful R-loop structures, thereby preventing DNA damage and cell death.

The direct reductive coupling of alkyl alcohol and aryl halide enables efficient access to valuable compounds, but the asymmetric pattern remains unknown. Here the authors describe the enantioconvergent deoxygenative reductive cross-coupling of unactivated alkyl alcohol and aryl bromide in the presence of an NHC activating agent.

In a prospective observational study, symptoms of anxiety and/or depression were associated with worse response to first-line treatment with immunotherapy in patients with advanced non-small-cell lung cancer.

China operates a national surveillance program for acute respiratory infections and sampled over 200,000 patients between 2009–2019. Here, the authors present results from this program and describe patterns by age, pathogen type, presence of pneumonia, and season.

Chronic rhinosinusitis with nasal polyps generally has a type 2 inflammatory eosinophilic profile but can have a treatment resistant neutrophilic phenotype. Here the authors characterise nasal polyps using single cell sequencing and spatial transcriptomics and show granzyme K⁺CD8⁺ T cells associated with neutrophilic inflammation which promote release of neutrophilic chemoattractants from fibroblasts.

KtrAB complex is essential in K⁺ uptake for bacteria. Here authors illustrate the synergism of ATP and Na⁺ in activating K+ uptake of KtrAB from Bacillus subtilis and its gating mechanism, which may also shed light on other Na⁺-activated K⁺ channels.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Gong et al. report bulk photovoltaic effect in rhombohedral stacked/interlayer sliding WS₂ with reconfigurable and nonvolatile photoresponsivity and develop a convolutional neural network for image processing based on two-terminal all 2D van der Waals layers vertical retinomorphic device.