Nature Search

Sphingosine-1-phosphate signalling activates E-Syt1 to facilitate HDL-derived cholesterol transport

Xu, Meng, St-Germain et al. report that S1P in HDL induces a calcium signalling cascade involving E-Syt1 that ultimately promotes the formation of contact sites between the endoplasmic reticulum and the plasma membrane, as well as HDL-derived cholesterol transport.

Zizhen Xu
Ying Meng
Dante Neculai
Research28 May 2025
Nature Cell Biology

Volume: 27, P: 918-930
Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway

Jinrui Wang
Shenghui Niu
Da Jia
ResearchOpen Access18 Mar 2025
Cell Discovery

Volume: 11, P: 1-14
Temporal oscillation of phospholipids promotes metabolic efficiency

Temporal oscillations in the abundance of different phospholipid species during the yeast cell cycle are reported, suggesting regulation and interplay of phospholipid synthesis, membrane fluidity and metabolic efficiency during cell division.

Sen Yang
Yuan Wang
Cunqi Ye
Research14 Apr 2025
Nature Chemical Biology

P: 1-12
Author Correction: ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions

Qianting Zhang
Mu Xiao
Xin-Hua Feng
Amendments and Corrections02 Feb 2021
Nature Cell Biology

Volume: 23, P: 293
Author Correction: IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin

Miao Tian
Xiumei Wang
Xiaojian Wang
Amendments and CorrectionsOpen Access29 Nov 2023
Nature Communications

Volume: 14, P: 1
S-acylation of ATGL is required for lipid droplet homoeostasis in hepatocytes

S-acylation of adipose triacylglyceride lipase, the rate-limiting enzyme of lipolysis, is shown to be required for lipolysis and lipid droplet homoeostasis in mice.

Yuping Zheng
Jishun Chen
Dante Neculai
Research14 Aug 2024
Nature Metabolism

Volume: 6, P: 1549-1565
Author Correction: Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation

Chengyu Shi
Ying Wang
Aifu Lin
Amendments and CorrectionsOpen Access10 Dec 2024
Nature Communications

Volume: 15, P: 1-4
Liver-specific gene PGRMC1 blocks c-Myc-induced hepatocarcinogenesis through ER stress-independent PERK activation

The roles of liver-specific genes in hepatocellular carcinoma (HCC) remain to be explored. Here the authors report that PGRMC1, localized to the endoplasmic reticulum (ER) membrane, functions as a tumor suppressor in HCC by inhibiting c-Myc protein translation via activation of PERK independent of ER stress.

Fubo Ji
Jianjuan Zhang
Junfang Ji
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-17
SNX8 enables lysosome reformation and reverses lysosomal storage disorder

Lysosomal storage disorders (LSDs) are severe genetic diseases currently without routine therapies. Here, the authors identified that SNX8 participates in lysosome reformation and serves as a potential drug target for new therapies to treat LSDs.

Xinran Li
Cong Xiang
Xin-Hua Feng
ResearchOpen Access22 Mar 2024
Nature Communications

Volume: 15, P: 1-15
Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders

Wang, Chen et al. describe cGAS–STING pathway overactivation in neurons in models of lysosome storage disorders (LSDs). Inactivation of neuronal cGAS–STING signalling alleviates neurodegeneration, suggesting a unifying mechanism mediating LSD pathogenesis.

Ailian Wang
Chen Chen
Pinglong Xu
Research22 Jan 2024
Nature Cell Biology

Volume: 26, P: 219-234
Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation

Cancer cells exploit immune checkpoint pathways, such as PD-1/PD-L1, to evade elimination by the immune system. Here, the authors demonstrate that TMUB1 regulates post-translational modifications of PD-L1 and that targeting the TMUB1/PD-L1 interaction promotes anti-tumour T cells responses

Chengyu Shi
Ying Wang
Aifu Lin
ResearchOpen Access14 Nov 2022
Nature Communications

Volume: 13, P: 1-18
ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions

Zhang et al. show that ALK phosphorylates SMAD4 at Tyr 95 to block its binding to DNA, representing a mutation-independent mechanism for blocking the tumour suppressor function of TGF-β in ALK-positive cancers.

Qianting Zhang
Mu Xiao
Xin-Hua Feng
Research21 Jan 2019
Nature Cell Biology

Volume: 21, P: 179-189
TBC1D23 mediates Golgi-specific LKB1 signaling

The LKB1 signaling is differentially regulated and has distinct functions at different subcellular compartments. Tu et al reports that TBC1D23 specifically regulates Golgi-LKB1 signaling and link this pathway to neurodevelopment disorders.

Yingfeng Tu
Qin Yang
Da Jia
ResearchOpen Access27 Feb 2024
Nature Communications

Volume: 15, P: 1-21
Oligomerization-primed coiled-coil ___domain interaction with Ubc13 confers processivity to TRAF6 ubiquitin ligase activity

Ubiquitin ligase TRAF6 catalyzes assembly of free polyubiquitin chains for TAK1 activation in the IL-1R/TLR pathways, but the mechanism underlying its processivity is unclear. Here, the authors show that TRAF6 coiled-coil oligomerization ___domain primes its interaction with Ubc13/Ub~Ubc13 to confer processivity.

Lin Hu
Jiafeng Xu
Zongping Xia
ResearchOpen Access09 Oct 2017
Nature Communications

Volume: 8, P: 1-13
IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin

The alternative mechanisms of innate immunity in tumorigenesis of colorectal cancers are unclear. Here, the authors report a non-canonical function of IRF3, a mediator of innate immune signalling, in the suppression of colorectal tumorigenesis and this is via the inhibition of Wnt/β-catenin pathway.

Miao Tian
Xiumei Wang
Xiaojian Wang
ResearchOpen Access13 Nov 2020
Nature Communications

Volume: 11, P: 1-15
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis

Zhang et al. report that a non-canonical cGAS–STING pathway activates PERK–eIF2α to elaborate cap-dependent mRNA translation and contributes to senescence and fibrosis.

Dan Zhang
Yutong Liu
Pinglong Xu
Research02 May 2022
Nature Cell Biology

Volume: 24, P: 766-782
HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity

Wu et al. demonstrate that HER2 recruits AKT1 to disrupt the STING signalosome, thereby suppressing damage-induced cellular senescence and STING-mediated antiviral and antitumour responses in vivo.

Shiying Wu
Qian Zhang
Pinglong Xu
Research22 Jul 2019
Nature Cell Biology

Volume: 21, P: 1027-1040
Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade

Zhang et al. show that YAP and TAZ suppress nucleic acid sensing and antiviral responses by inhibiting the TBK1 kinase. Conversely, Hippo pathway activity inactivates YAP/TAZ to relieve TBK1 suppression and enhance antiviral defence in zebrafish.

Qian Zhang
Fansen Meng
Pinglong Xu
Research27 Mar 2017
Nature Cell Biology

Volume: 19, P: 362-374
Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia

Lijing Wang
Shuchen Gu
Xin-Hua Feng
ResearchOpen Access24 Mar 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-14

Search

Filter By:

Search

Quick links