Liver fibrosis involves the activation of hepatic stellate cells (HSCs). Here the authors show that the guanine exchange factor GIV is specifically upregulated in HSCs, and that it serves as an integrator of multi-receptor driven pro-fibrotic signalling in the liver via its ability to activate G proteins.
- Inmaculada Lopez-Sanchez
- Ying Dunkel
- Pradipta Ghosh
