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Showing 1–4 of 4 results
Advanced filters: Author: Pyung-Gang Lee Clear advanced filters

  • The analysis of microbial genomes from human archaeological samples offers a snapshot of ancient pathogens. Here, Hodgins et al. analyze metagenomic datasets from 38 human archaeological samples and identify bacterial genomic sequences related to modern-day Clostridium tetani, encoding tetanus neurotoxins.

    • Harold P. Hodgins
    • Pengsheng Chen
    • Andrew C. Doxey
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Botulinum neurotoxin E (BoNT/E) is a major cause of botulism and paradoxically also a drug in clinical trial. Here, the authors show that BoNT/E binding and uptake require glycosylation of its host receptor SV2 with high selectivity for SV2A and SV2B over SV2C.

    • Zheng Liu
    • Pyung-Gang Lee
    • Rongsheng Jin
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Botulinum neurotoxins (BoNTs) are a family of protein toxins produced by clostridial bacteria that cause muscle paralysis, and exhibit structural and functional diversity within the BoNTs family. Here, the authors report the cryo-EM structure complex of a newly identified serotype BoNT/X with their partner protein NTNH/X and reveal the complex’s pH-dependent stability and receptor-binding properties.

    • Markel Martínez-Carranza
    • Jana Å kerlová
    • PÃ¥l Stenmark
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-15