Search

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Excitonic pairing in fractional quantum Hall states shows two new quantum phases, including a fractional exciton condensate and an unusual type of exciton that obeys fermionic or anyonic quantum statistics.

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

Functional imaging and multiplexed in situ hybridization were combined to investigate how trigeminal neurons encode heat and mechanical stimuli, revealing distinct cellular mechanisms for continuing pain, heat hypersensitivity and tactile allodynia during inflammation.

Like yield stress materials, tissues flow under significant stress through collective cell rearrangements. This study uses theoretical modeling to describe simulated tissue avalanches, and offers a fast method to infer stress from static snapshots.

Nguyen et al. identify TDP-43 and METTL3 as key regulators of disrupted RNA splicing in Huntington’s disease, offering insight into how TDP-43 mislocalization and aberrant m6A RNA modification and localization relate to disease pathogenesis.

Intense light pulses can induce symmetry breaking, as for the generation of ferroelectricity in SrTiO₃. Using ultrafast X-ray diffuse scattering at a free-electron laser, nonlinear phonon interactions that occur on such mid-IR excitation are observed, with a theory for the dynamics presented.

Understanding transformations of non-equilibrium materials is a key open scientific question. Here the pathway by which different polar supertextures undergo dynamical correlations and collectively transform into a metastable supercrystal state is revealed experimentally and theoretically over seven orders of magnitude timescale.

The most up-to-date combination of results on the properties of the Higgs boson is reported, which indicate that its properties are consistent with the standard model predictions, within the precision achieved to date.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

Coupling a single-photon emitter to a mechanical resonator enables the generation of single phonons. Here, the authors study the interaction of a single-photon emitter and a phononic-crystal resonator in the sideband-resolved regime.

Under field conditions, acquisitive tree species generally grow slowly, whereas conservative species show generally higher realized growth, owing to their ability to tolerate unfavourable environmental conditions.

The Large Hadron Collider beauty collaboration reports a test of lepton flavour universality in decays of bottom mesons into strange mesons and a charged lepton pair, finding evidence of a violation of this principle postulated in the standard model.

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

Efficient protocols for comparing quantum states generated on different quantum computing platforms are becoming increasingly important. Zhu et al. demonstrate cross-platform verification using randomized measurements that allow for scaling to larger systems as compared to full quantum state tomography.

Systematic studies are needed to discover molecular determinants of blood brain barrier dysfunction in Alzheimer’s disease. This study identifies perturbed pericytic SMAD3-astrocytic VEGFA interactions as a potential driver of this dysfunction.

One of the obstacles in implementing solar water splitting is the requirement for materials with high internal quantum efficiency. Here, the authors investigate the effects of magnesium doping on the Fermi levels of gallium nitride nanowires, and tune this value to maximize redox efficiency.

Genome-wide analyses identify common variants associated with 11 distinct neuropathology endophenotypes, providing insights into the mechanisms underlying the genetic risk of Alzheimer’s disease and related dementias.

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

Senescent melanocytes of skin nevi drive hyperactivation of hair growth through the signalling factor SPP1.

OligoFISSEQ combines Oligopaints with fluorescence in situ sequencing to enable the 3D mapping of many regions across the genome in human cells to interrogate genome organization at improved genomic resolution. OligoFISSEQ is compatible with immunochemistry and OligoSTORM for super-resolution imaging.

Entanglement between single photons and solid-state emitters is a key component for photonic quantum computing and networks. Here, using a single electron spin in a quantum dot, the authors present a deterministic photon source achieving three-qubit entanglement of one electron spin and two photons.

Bacterial cells use a self-generated extracellular matrix of various biomolecules in order to form biofilms and promote their stability. Here, the authors present a method for genetically controlling the composition of this extracellular matrix to yield more functional biofilms.

This study finds that in-cave processes affect speleothem oxygen isotope records. Correcting for these processes improves agreement with other regional records and climate models, providing a more accurate reflection of past hydroclimate change.

Deconwolf is a computationally efficient and user-friendly software tool for fluorescence microscopy image deconvolution that improves the analysis of diverse fluorescence in situ hybridization methods and can handle large datasets.

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

The second Global Amphibian Assessment finds that the status of amphibians is continuing to deteriorate globally, driven predominantly by climate change, disease and habitat loss.

Impaired wound healing that leads to scar remains a clinical challenge. Here, the authors study the effects of hydrogel crosslinking on cellular behavior in skin wounds and its effect on immune and stromal cell activity.

Refractory high entropy alloys (RHEAs) have recently been developed in the context of high-temperature and severe environmental applications. Here the authors, by combining simulation and experiments, develop an irradiation resistant, thermally stable, and strong RHEA for nuclear application.

The heterogeneity of whole-exome sequencing (WES) data generation methods presents a challenge to joint analysis. Here, the authors present a bioinformatics strategy to generate high-quality data from processing diversely generated WES samples, as applied in the Alzheimer’s Disease Sequencing Project.

Bayati et al. discovered that sequential treatment of iPSC-derived dopaminergic neurons with α-synuclein fibrils and proinflammatory cytokines leads to the formation of Lewy body–like inclusions, through the downregulation of lysosomal proteins.

Van Dooijeweert et al. conducted a prospective study on the clinical implementation of artificial-intelligence-assisted detection of sentinel lymph node metastasis in persons with breast cancer and report on its effects, including on time and cost.

In this Review, Huang et al. discuss the current status of hepatocellular carcinoma surveillance, the remaining challenges, including the changing aetiology of liver disease, and strategies to improve the utilization and quality of surveillance.

How the dauer, an alternative developmental stage in nematodes, exhibits distinct behavioral traits remains unclear. Here, the authors reveal the neural circuitry underlying these distinctions by reconstructing the dauer connectome and comparing it with other stages.

The role of IgG glycosylation in the immune response has been studied, but less is known about IgM glycosylation. Here the authors characterize glycosylation of SARS-CoV-2 spike specific IgM and show that it correlates with COVID-19 severity and affects complement deposition.

Ten years after the discovery of the Higgs boson, the ATLAS  experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

A combination of genome-wide CRISPR screens in target cancer cells identifies pathways that regulate γδ T cell killing and BTN3A cell surface expression.

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.