Nature Search

Targeting transcription in heart failure via CDK7/12/13 inhibition

In this study, Hsu et al. show that inhibition of CDK7/12/13 attenuates maladaptive transcriptional activation in cultured cardiomyocytes and a mouse model of heart failure, suggesting that targeting the transcription machinery might be a therapeutic approach to treat heart failure with reduced ejection fraction.

Austin Hsu
Qiming Duan
Saptarsi M. Haldar
ResearchOpen Access27 Jul 2022
Nature Communications

Volume: 13, P: 1-11
Resequencing of 1,143 indica rice accessions reveals important genetic variations and different heterosis patterns

Hybrid rice cultivars are widely planted around the world. Here, the authors resequence 1,143 indica accessions, focusing on the parents of superior hybrid rice lines in China, and reveal genetic loci that are associated with heterosis via measuring frequency of parental variation difference (FPVD).

Qiming Lv
Weiguo Li
Dingyang Yuan
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-10
STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation

Xiaohong Wang
Tao Chen
Cheng Zhang
ResearchOpen Access25 Apr 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-17
A transcriptional switch governs fibroblast activation in heart disease

BET proteins regulate a reversible transcriptional switch that governs fibroblast activation in heart disease through the transcription factor MEOX1.

Michael Alexanian
Pawel F. Przytycki
Deepak Srivastava
Research23 Jun 2021
Nature

Volume: 595, P: 438-443
OsMADS17 simultaneously increases grain number and grain weight in rice

The trade-off between grain number and grain weight is a major obstacle for increasing rice yield. Here, the authors show that variation in 5’ UTR of OsMADS17 can simultaneously increase grain number and grain weight through decreasing mRNA translation efficiency.

Yuanjie Li
Sheng Wu
Chuanqing Sun
ResearchOpen Access29 May 2023
Nature Communications

Volume: 14, P: 1-13
Allelic variation of the rice blast resistance gene Pid3 in cultivated rice worldwide

Qiming Lv
Zhiyuan Huang
Lihuang Zhu
ResearchOpen Access04 Sept 2017
Scientific Reports

Volume: 7, P: 1-13
Forecasting rice latitude adaptation through a daylength-sensing-based environment adaptation simulator

Breeding crop cultivars with better environmental adaptability could support crop yield stability to mitigate the effects of climate change. Combining transcriptional dynamics of florigen genes and statistical models, the daylength-sensing-based environment adaptation simulator can forecast the latitude adaptability of rice cultivars and has application potential in other crops.

Leilei Qiu
Qinqin Wu
Xinhao Ouyang
Research20 May 2021
Nature Food

Volume: 2, P: 348-362
Investigation of Pathogenic Genes in Chinese sporadic Hypertrophic Cardiomyopathy Patients by Whole Exome Sequencing

Jing Xu
Zhongshan Li
Qiming Dai
ResearchOpen Access17 Nov 2015
Scientific Reports

Volume: 5, P: 1-13
Common and differential connectivity profiles of deep brain stimulation and capsulotomy in refractory obsessive-compulsive disorder

Xiaoyu Chen
Zhen Wang
Zheng Wang
Research26 Oct 2021
Molecular Psychiatry

Volume: 27, P: 1020-1030
Toripalimab plus chemotherapy for first line treatment of advanced non-small cell lung cancer (CHOICE-01): final OS and biomarker exploration of a randomized, double-blind, phase 3 trial

Jia Zhong
Kailun Fei
Jie Wang
ResearchOpen Access24 Dec 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-9
Knockout of OsNramp5 using the CRISPR/Cas9 system produces low Cd-accumulating indica rice without compromising yield

Li Tang
Bigang Mao
Bingran Zhao
ResearchOpen Access31 Oct 2017
Scientific Reports

Volume: 7, P: 1-12

Search

Targeting transcription in heart failure via CDK7/12/13 inhibition

Resequencing of 1,143 indica rice accessions reveals important genetic variations and different heterosis patterns

STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation

A transcriptional switch governs fibroblast activation in heart disease

OsMADS17 simultaneously increases grain number and grain weight in rice

Allelic variation of the rice blast resistance gene Pid3 in cultivated rice worldwide

Forecasting rice latitude adaptation through a daylength-sensing-based environment adaptation simulator

Investigation of Pathogenic Genes in Chinese sporadic Hypertrophic Cardiomyopathy Patients by Whole Exome Sequencing

Common and differential connectivity profiles of deep brain stimulation and capsulotomy in refractory obsessive-compulsive disorder

Toripalimab plus chemotherapy for first line treatment of advanced non-small cell lung cancer (CHOICE-01): final OS and biomarker exploration of a randomized, double-blind, phase 3 trial

Knockout of OsNramp5 using the CRISPR/Cas9 system produces low Cd-accumulating indica rice without compromising yield

Search

Quick links

Search

Filter By:

Search

Quick links