Nature Search

A synthetic chronogenetic gene circuit for programmed circadian drug delivery

Circadian medicine, or chronotherapy, seeks to improve drug efficacy based on individuals’ circadian rhythms. Here, the authors combine principles of tissue engineering and synthetic biology to create a chronogenetic gene circuit for cell-based delivery of biologic drugs at controlled times of day.

Lara Pferdehirt
Anna R. Damato
Farshid Guilak
ResearchOpen Access07 Feb 2025
Nature Communications

Volume: 16, P: 1-11
Cellular mechano-environment regulates the mammary circadian clock

Circadian clocks regulate physiological and behavioural rhythms. Here, the authors show that the stiffness of the extracellular environment regulates circadian clocks in murine breast epithelium via Rho signalling, and explain how extracellular matrix stiffening in aging affects circadian rhythm, with implication in disease.

Nan Yang
Jack Williams
Qing-Jun Meng
ResearchOpen Access30 Jan 2017
Nature Communications

Volume: 8, P: 1-13
Mechanical loading and hyperosmolarity as a daily resetting cue for skeletal circadian clocks

The 24-hour circadian clocks in cartilage and intervertebral disc play key roles in regulating tissue physiology, yet how they are reset on a daily basis remains elusive. Here the authors show that daily patterns of mechanical loading and associated changes in osmolarity provide a tissue-type specific entrainment time cue for these skeletal clocks.

Michal Dudek
Dharshika R. J. Pathiranage
Qing-Jun Meng
ResearchOpen Access14 Nov 2023
Nature Communications

Volume: 14, P: 1-12
Author Correction: Macromolecular condensation buffers intracellular water potential

Joseph L. Watson
Estere Seinkmane
Emmanuel Derivery
Amendments and CorrectionsOpen Access08 Apr 2024
Nature

Volume: 628, P: E4
The brain–joint axis in osteoarthritis: nerves, circadian clocks and beyond

Emerging evidence suggests the nervous system, including the circadian timing system, influences susceptibility to osteoarthritis (OA) via direct and indirect effects. This Review describes the interactions between the brain and the joints in the context of OA, ageing, obesity and inflammation, and outlines therapeutic and research opportunities in this field.

Francis Berenbaum
Qing-Jun Meng
Reviews16 Jun 2016
Nature Reviews Rheumatology

Volume: 12, P: 508-516
Macromolecular condensation buffers intracellular water potential

Water thermodynamics drive changes in macromolecular assembly that rapidly restore intracellular water availability in response to physiological fluctuations in temperature, pressure and osmotic strength.

Joseph L. Watson
Estere Seinkmane
Emmanuel Derivery
ResearchOpen Access18 Oct 2023
Nature

Volume: 623, P: 842-852
Circadian control of the secretory pathway maintains collagen homeostasis

Here, Chang et al. show that the circadian clock regulates secretion resulting in nocturnal procollagen synthesis and daytime collagen fibril assembly in mice to maintain the homeostasis of the collagen network.

Joan Chang
Richa Garva
Karl E. Kadler
Research06 Jan 2020
Nature Cell Biology

Volume: 22, P: 74-86
Osteoarthritis-like pathologic changes in the knee joint induced by environmental disruption of circadian rhythms is potentiated by a high-fat diet

Ranjan Kc
Xin Li
Hee-Jeong Im
ResearchOpen Access20 Nov 2015
Scientific Reports

Volume: 5, P: 1-7
The accuracy of cortical bone trajectory screw placement guided by spinous process clamp hardware in lumbar spinal surgery: a retrospective study

Xi-nuo Zhang
Qing-jun Su
Yu-zeng Liu
ResearchOpen Access30 Sept 2023
Scientific Reports

Volume: 13, P: 1-9
Gremlin-2 is a BMP antagonist that is regulated by the circadian clock

Ching-Yan Chloé Yeung
Nicole Gossan
Qing-Jun Meng
ResearchOpen Access05 Jun 2014
Scientific Reports

Volume: 4, P: 1-8
Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration

Dong Wang
Pandi Peng
Liu Yang
ResearchOpen Access25 Feb 2022
Bone Research

Volume: 10, P: 1-13
Knockdown of cytokeratin 8 overcomes chemoresistance of chordoma cells by aggravating endoplasmic reticulum stress through PERK/eIF2α arm of unfolded protein response and blocking autophagy

Di Wang
Peiran Zhang
Zhuojing Luo
ResearchOpen Access25 Nov 2019
Cell Death & Disease

Volume: 10, P: 1-18

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