Nature Search

Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe²⁺ through TRPML1 channel

Lysosomes are best known for their roles in inflammatory responses via autophagy. Here, Xing et al., find that lysosomes regulate macrophage inflammatory responses by finely controlling interleukin-1β production, altering lysosomal Fe2+ release through the TRPML1 channel.

Yanhong Xing
Meng-meng Wang
Wuyang Wang
ResearchOpen Access24 Jan 2025
Nature Communications

Volume: 16, P: 1-20
Living fabrication of functional semi-interpenetrating polymeric materials

Cell based materials production has potential for generating diverse materials with a range of functions. Here, the authors report development of living fabrication of biohybrid semi interpenetrating polymer networks by encapsulating protein producing bacteria within polymer microcapsules.

Zhuojun Dai
Xiaoyu Yang
Lingchong You
ResearchOpen Access08 Jun 2021
Nature Communications

Volume: 12, P: 1-9
Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1

Ovarian aging has an important role in health and fertility; however, the molecular mechanisms underlying it remain incompletely understood. Here the authors use single-cell and spatial transcriptomics in reproductively young, middle-aged and older human ovarian tissue to elucidate ovarian aging. They describe spatiotemporal changes in ovarian cells and highlight the important regulatory role of FOXP1.

Meng Wu
Weicheng Tang
Shixuan Wang
ResearchOpen Access09 Apr 2024
Nature Aging

Volume: 4, P: 527-545
Tumor detection on bronchoscopic images by unsupervised learning

Qingqing Liu
Haoliang Zheng
Zhihui Shi
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Macrophage mitochondrial fission improves cancer cell phagocytosis induced by therapeutic antibodies and is impaired by glutamine competition

Li et al. demonstrate mitochondrial fission in macrophages as key for phagocytosis induced by therapeutic antibodies. They identify overexpression of GFPT2 as an inhibitor of the process and phase transition of the phagocytic machinery as its regulator.

Jiang Li
Yingying Ye
Shicheng Su
Research28 Apr 2022
Nature Cancer

Volume: 3, P: 453-470
The role of oxygen-vacancy in bifunctional indium oxyhydroxide catalysts for electrochemical coupling of biomass valorization with CO₂ conversion

Electrochemical coupling of biomass valorization with CO2 conversion provides a promising approach to generate value-added chemicals on both sides. However, bifunctional catalysts are lacking. Here the authors report oxygen-vacancy-rich indium oxyhydroxide as a bifunctional catalyst for CO2 reduction to formate and 5-hydroxymethylfurfural electrooxidation to 2,5-furandicarboxylic acid with faradaic efficiencies for both > 90.0%.

Fenghui Ye
Shishi Zhang
Chuangang Hu
ResearchOpen Access11 Apr 2023
Nature Communications

Volume: 14, P: 1-14
Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells

Lipid metabolism has been linked to iNKT function largely as it impacts processing and presentation of lipids they recognize. Here the authors show that iNKT-intrinsic lipid biosynthesis is important for their function but is impaired in tumors, and its restoration with PPARγ agonist drugs promotes anti-tumor iNKT response.

Sicheng Fu
Kaixin He
Li Bai
ResearchOpen Access23 Jan 2020
Nature Communications

Volume: 11, P: 1-15
E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses

The innate immune response to many RNA viruses depends on recognition of viral RNA by RIG-I. Here the authors show that, upon virus infection, FBXW7 interacts with RIG-I and inhibits ubiquitin-mediated degradation of RIG-I, resulting in increased interferon signallingin vitro and in vivo.

Yinjing Song
Lihua Lai
Qingqing Wang
ResearchOpen Access13 Mar 2017
Nature Communications

Volume: 8, P: 1-14
Analysis of Clinical and Laboratory Findings of Idiopathic Sudden Sensorineural Hearing Loss

Wen Xie
Qingqing Dai
Maoli Duan
ResearchOpen Access08 Apr 2020
Scientific Reports

Volume: 10, P: 1-8
The relationship between MUC5B promoter, TERT polymorphisms and telomere lengths with radiographic extent and survival in a Chinese IPF cohort

Hui Wang
Yi Zhuang
Jinghong Dai
ResearchOpen Access25 Oct 2019
Scientific Reports

Volume: 9, P: 1-7
Prevalence of Stroke and Vascular Risk Factors in China: a Nationwide Community-based Study

Qi Li
Hao Wu
Ying Shen
ResearchOpen Access25 Jul 2017
Scientific Reports

Volume: 7, P: 1-7
Refining antipsychotic treatment strategies in schizophrenia: discovery of genetic biomarkers for enhanced drug response prediction

Luan Chen
Cong Huai
Shengying Qin
Research19 Nov 2024
Molecular Psychiatry

Volume: 30, P: 2362-2371
Progress in regulating ecosystem services research: an implication for the Karst World Heritage sites

Yating Mu
Kangning Xiong
Qingqing Xie
ReviewsOpen Access24 Apr 2025
npj Heritage Science

Volume: 13, P: 1-15
A novel fatty acid metabolism-related signature identifies MUC4 as a novel therapy target for esophageal squamous cell carcinoma

Shanshan Li
Zhengcao Liu
Shengjun Ji
ResearchOpen Access30 May 2024
Scientific Reports

Volume: 14, P: 1-15
Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke

Chao Wei
Zhongnan Xiao
Qian Li
Research08 May 2024
Cell Death & Differentiation

Volume: 31, P: 983-998
Impacts of climate change and human activities on different degraded grassland based on NDVI

Qingqing Hou
Zhenxia Ji
Xiaojun Yu
ResearchOpen Access23 Sept 2022
Scientific Reports

Volume: 12, P: 1-18
Identification of ecological networks and nodes in Fujian province based on green and blue corridors

Qingqing Zhou
Cecil C. Konijnendijk van den Bosch
Jianwen Dong
ResearchOpen Access22 Oct 2021
Scientific Reports

Volume: 11, P: 1-18
Complex-frequency waves: beat loss and win sensitivity

Qingqing Cheng
Tao Li
News & ViewsOpen Access01 Feb 2024
Light: Science & Applications

Volume: 13, P: 1-3
Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription

Dan Tang
Chunjing Chen
Shiqian Qi
ResearchOpen Access18 Feb 2020
Cell Discovery

Volume: 6, P: 1-11
A new quasi-one-dimensional compound Ba₃TiTe₅ and superconductivity induced by pressure

A new quasi 1D compound Ba₃TiTe₅ was synthesized at high pressure and high temperature, which has been evidenced to be a well-defined 1D conductor. Here, for Ba₃TiTe₅, in-situ high-pressure techniques were employed to study the emerging physics dependent on interchain hopping, such as the Umklapp scattering effect, SDW/CDW, superconductivity and non-Fermi Liquid behavior. The pressure induced superconductivity was observed. It is suggested that the appearance of superconductivity is associated with the fluctuation due to the suppression of Umklapp gap and the enhancement of T_c is related with the fluctuation of the SDW/CDW.

Jun Zhang
Yating Jia
Changqing Jin
ResearchOpen Access25 Oct 2019
NPG Asia Materials

Volume: 11, P: 1-10
NF-κB p50 activation associated with immune dysregulation confers poorer survival for diffuse large B-cell lymphoma patients with wild-type p53

Qingqing Cai
Meifeng Tu
Ken H Young
Research10 Mar 2017
Modern Pathology

Volume: 30, P: 854-876

Search

Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe²⁺ through TRPML1 channel

Living fabrication of functional semi-interpenetrating polymeric materials

Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1

Tumor detection on bronchoscopic images by unsupervised learning

Macrophage mitochondrial fission improves cancer cell phagocytosis induced by therapeutic antibodies and is impaired by glutamine competition

The role of oxygen-vacancy in bifunctional indium oxyhydroxide catalysts for electrochemical coupling of biomass valorization with CO₂ conversion

Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells

E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses

Analysis of Clinical and Laboratory Findings of Idiopathic Sudden Sensorineural Hearing Loss

The relationship between MUC5B promoter, TERT polymorphisms and telomere lengths with radiographic extent and survival in a Chinese IPF cohort

Prevalence of Stroke and Vascular Risk Factors in China: a Nationwide Community-based Study

Refining antipsychotic treatment strategies in schizophrenia: discovery of genetic biomarkers for enhanced drug response prediction

Progress in regulating ecosystem services research: an implication for the Karst World Heritage sites

A novel fatty acid metabolism-related signature identifies MUC4 as a novel therapy target for esophageal squamous cell carcinoma

Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke

Impacts of climate change and human activities on different degraded grassland based on NDVI

Identification of ecological networks and nodes in Fujian province based on green and blue corridors

Complex-frequency waves: beat loss and win sensitivity

Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription

A new quasi-one-dimensional compound Ba₃TiTe₅ and superconductivity induced by pressure

NF-κB p50 activation associated with immune dysregulation confers poorer survival for diffuse large B-cell lymphoma patients with wild-type p53

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