Wei et al. found that the nuclear E3 ligase ubiquitin protein ligase E3 component n-recognin 5 (UBR5) ubiquitinated VGLL4 at Lys61 for its degradation, which permits Hippo–YAP signaling for the development of liver biliary system in mice and multiple cancers in humans.
- Jinsong Wei
- Zhifa Cao
- Bing Zhao