Nature Search

Natural and targeted circuit reorganization after spinal cord injury

The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases.

Mark A. Anderson
Jordan W. Squair
Grégoire Courtine
Reviews17 Nov 2022
Nature Neuroscience

Volume: 25, P: 1584-1596
Hypothalamic deep brain stimulation augments walking after spinal cord injury

Whole-brain anatomical and activity surveys identify the lateral hypothalamus as a key driver of recovery from spinal cord injury, leading to a deep brain stimulation therapy that augments the recovery of walking in humans.

Newton Cho
Jordan W. Squair
Grégoire Courtine
Research02 Dec 2024
Nature Medicine

Volume: 30, P: 3676-3686
Fully textured monolithic perovskite/silicon tandem solar cells with 25.2% power conversion efficiency

An optimized two-step deposition process allows the formation of uniform layers of metal halide perovskites on textured silicon layers, enabling tandem silicon/perovskite solar cells with improved optical design and efficiency.

Florent Sahli
Jérémie Werner
Christophe Ballif
Research11 Jun 2018
Nature Materials

Volume: 17, P: 820-826
Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica

The Tabulae Paralytica, a compilation of four molecular atlases of spinal cord injury, provides a window into the pathobiology of spinal cord injury, establishing a framework for integrating multimodal, genome-scale measurements in four dimensions to study biology and medicine.

Michael A. Skinnider
Matthieu Gautier
Grégoire Courtine
Research19 Jun 2024
Nature

Volume: 631, P: 150-163
Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Implantation of a multielectrode paddle that allows personalized electrical stimulation to all regions of the spinal cord involved in leg and trunk movements rapidly restores motor function in patients with spinal cord injury with complete paralysis.

Andreas Rowald
Salif Komi
Grégoire Courtine
Research07 Feb 2022
Nature Medicine

Volume: 28, P: 260-271
Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

This paper describes a neurotechnology that interacts with neural circuits in the spinal cord to restore arm and hand control after injury. With this implant, monkeys with paralysis recovered the ability to reach and grasp just a few days after injury.

Beatrice Barra
Sara Conti
Marco Capogrosso
Research30 Jun 2022
Nature Neuroscience

Volume: 25, P: 924-934
Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury

Deep brain stimulation and epidural electrical stimulation of the spinal cord enable locomotion in humans with spinal cord injury (SCI) but the potential synergy between both approaches is unclear. The authors show that a complex technological approach is required to enable volitional walking in rats with SCI.

Marco Bonizzato
Nicholas D. James
Gregoire Courtine
ResearchOpen Access26 Mar 2021
Nature Communications

Volume: 12, P: 1-14
The neurons that restore walking after paralysis

Transcriptomic analysis following epidural electrical stimulation of the lumbar spinal cord during neurorehabilitation in mice identifies a population of neurons that orchestrates the restoration of walking following paralysis.

Claudia Kathe
Michael A. Skinnider
Grégoire Courtine
ResearchOpen Access09 Nov 2022
Nature

Volume: 611, P: 540-547
Simple processing of back-contacted silicon heterojunction solar cells using selective-area crystalline growth

The most efficient silicon solar cells use interdigitated back-contact silicon heterojunction architectures. Here, the authors fabricate this type of cell via a simpler process, using an interband silicon tunnel junction for the electron contact and reaching a certified efficiency higher than 22%.

Andrea Tomasi
Bertrand Paviet-Salomon
Christophe Ballif
Research24 Apr 2017
Nature Energy

Volume: 2, P: 1-8
Confronting false discoveries in single-cell differential expression

Differential expression analysis of single-cell transcriptomics allows scientists to dissect cell-type-specific responses to biological perturbations. Here, the authors show that many commonly used methods are biased and can produce false discoveries.

Jordan W. Squair
Matthieu Gautier
Grégoire Courtine
ResearchOpen Access28 Sept 2021
Nature Communications

Volume: 12, P: 1-15
Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Optogenetics is applied to the entire mouse spinal cord.

Claudia Kathe
Frédéric Michoud
Grégoire Courtine
Research27 Sept 2021
Nature Biotechnology

Volume: 40, P: 198-208
Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

An epidural spinal cord stimulation system regulates blood pressure in the acute and chronic phases of spinal cord injury.

Jordan W. Squair
Matthieu Gautier
Aaron A. Phillips
Research27 Jan 2021
Nature

Volume: 590, P: 308-314
Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Analysis of synergistic muscle activations during locomotion and anatomical tracing of muscle synergy representations in the rodent spinal cord guide the development of a new spinal implant for neuromodulation therapy. In multiple rodent models of spinal cord injury, spatiotemporal stimulation that mimics naturalistic muscle activation patterns promotes improved functional recovery over previously described continuous stimulation protocols.

Nikolaus Wenger
Eduardo Martin Moraud
Grégoire Courtine
Research18 Jan 2016
Nature Medicine

Volume: 22, P: 138-145
Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Severe spinal cord contusions interrupt all corticospinal input. Neuroprosthetic rehabilitation rerouted cortical command through residual reticulospinal pathways, mediating motor cortex dependent recovery of locomotion in otherwise paralyzed rats.

Leonie Asboth
Lucia Friedli
Gregoire Courtine
Research19 Mar 2018
Nature Neuroscience

Volume: 21, P: 576-588
A brain–spine interface alleviating gait deficits after spinal cord injury in primates

A wireless brain–spine interface is presented that enables macaques with a spinal cord injury to regain locomotor movements of a paralysed leg.

Marco Capogrosso
Tomislav Milekovic
Grégoire Courtine
Research09 Nov 2016
Nature

Volume: 539, P: 284-288
Cell type prioritization in single-cell data

The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis.

Michael A. Skinnider
Jordan W. Squair
Grégoire Courtine
Research20 Jul 2020
Nature Biotechnology

Volume: 39, P: 30-34
Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models

An approach to reproducing episodes of hypotension-mimicking orthostatic challenges while monitoring arterial blood pressure and sympathetic nerve activity over several months in preclinical models of chronic neurological disorders, using a combination of available telemetry technologies, optogenetics and neuronal tract tracing.

Jan Elaine Soriano
Rémi Hudelle
Gregoire Courtine
Protocols23 Nov 2022
Nature Protocols

Volume: 18, P: 340-373

Search

Natural and targeted circuit reorganization after spinal cord injury

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Fully textured monolithic perovskite/silicon tandem solar cells with 25.2% power conversion efficiency

Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury

The neurons that restore walking after paralysis

Simple processing of back-contacted silicon heterojunction solar cells using selective-area crystalline growth

Confronting false discoveries in single-cell differential expression

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

A brain–spine interface alleviating gait deficits after spinal cord injury in primates

Cell type prioritization in single-cell data

Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models

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