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Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes

This study uncovered genetic associations with environmental sensitivity in psychiatric and neurodevelopmental traits in an international collaboration using data from more than 21,000 monozygotic twins—the largest genetic study of monozygotic twin differences to date.

Elham Assary
Jonathan R. I. Coleman
Robert Keers
ResearchOpen Access10 Jun 2025
Nature Human Behaviour

P: 1-14
Associations between common genetic variants and income provide insights about the socio-economic health gradient

This genome-wide association study identifies 162 genetic loci linked to income, shedding light on the complex interplay between genetics, income, education and health.

Hyeokmoon Kweon
Casper A. P. Burik
Philipp D. Koellinger
ResearchOpen Access28 Jan 2025
Nature Human Behaviour

Volume: 9, P: 794-805
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Within-sibship genome-wide association analyses using data from 178,076 siblings illustrate differences between population-based and within-sibship GWAS estimates for phenotypes influenced by demographic and indirect genetic effects.

Laurence J. Howe
Michel G. Nivard
Neil M. Davies
ResearchOpen Access09 May 2022
Nature Genetics

Volume: 54, P: 581-592
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

A genome-wide association study in ~3 million individuals identifies 3,952 independent variants associated with educational attainment. A polygenic index explains 12–16% of variance for this trait and contributes to risk prediction for ten diseases.

Aysu Okbay
Yeda Wu
Alexander I. Young
ResearchOpen Access31 Mar 2022
Nature Genetics

Volume: 54, P: 437-449
Systematic review and meta-analysis determining the benefits of in vivo genetic therapy in spinal muscular atrophy rodent models

Ellie M. Chilcott
Evalyne W. Muiruri
Rafael J. Yáñez-Muñoz
ResearchOpen Access06 Oct 2021
Gene Therapy

Volume: 29, P: 498-512
Resource profile and user guide of the Polygenic Index Repository

Benjamin et al. construct polygenic indexes (DNA-based predictors) for 47 phenotypes and make them available to researchers in 11 datasets. They also present a theoretical framework and estimator to help interpret analyses using polygenic indexes.

Joel Becker
Casper A. P. Burik
Aysu Okbay
Research17 Jun 2021
Nature Human Behaviour

Volume: 5, P: 1744-1758
Muscle overexpression of Klf15 via an AAV8-Spc5-12 construct does not provide benefits in spinal muscular atrophy mice

Nina Ahlskog
Daniel Hayler
Melissa Bowerman
ResearchOpen Access20 Apr 2020
Gene Therapy

Volume: 27, P: 505-515

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Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes

Associations between common genetic variants and income provide insights about the socio-economic health gradient

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

Systematic review and meta-analysis determining the benefits of in vivo genetic therapy in spinal muscular atrophy rodent models

Resource profile and user guide of the Polygenic Index Repository

Muscle overexpression of Klf15 via an AAV8-Spc5-12 construct does not provide benefits in spinal muscular atrophy mice

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