Mensch et al. investigate how neuronal activity regulates CNS myelination in vivo, using zebrafish as a model. They find that blocking synaptic vesicle release reduces, and that stimulating neuronal activity increases, the number of myelin sheath made by the myelinating glia of the CNS (oligodendrocytes). These data show that neuronal activity regulates the myelinating capacity of individual oligodendrocytes.
- Sigrid Mensch
- Marion Baraban
- David A Lyons
