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Immunogenicity and safety of mRNA-based seasonal influenza vaccines encoding hemagglutinin and neuraminidase

Improving neuraminidase content of influenza vaccines is a major focus of vaccine development. Here the authors present safety and immunogenicity of seasonal influenza mRNA vaccine candidates simultaneously encoding hemagglutinin and neuraminidase antigens in a first in-human study.

Amanda K. Rudman Spergel
Ivan T. Lee
Raffael Nachbagauer
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-9
Pandemic influenza virus vaccines boost hemagglutinin stalk-specific antibody responses in primed adult and pediatric cohorts

Raffael Nachbagauer
Bruno Salaun
Carine Claeys
ResearchOpen Access06 Dec 2019
npj Vaccines

Volume: 4, P: 1-12
Safety and immunogenicity of a phase 1/2 randomized clinical trial of a quadrivalent, mRNA-based seasonal influenza vaccine (mRNA-1010) in healthy adults: interim analysis

Here the authors report initial findings of a phase 1 clinical trial, showing that an investigational, mRNA-based vaccine for seasonal influenza (mRNA-1010) has no safety concerns and produces immune responses in adults that are similar or higher than a licensed comparator vaccine.

Ivan T. Lee
Raffael Nachbagauer
Robert Paris
ResearchOpen Access19 Jun 2023
Nature Communications

Volume: 14, P: 1-11
Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial

First-in-human trial of a self-assembling, ferritin nanoparticle-based influenza vaccine shows evidence that this new platform can elicit neutralizing and cross-reactive antibodies and has potential for further vaccine development.

Katherine V. Houser
Grace L. Chen
Colin Tran
Research03 Feb 2022
Nature Medicine

Volume: 28, P: 383-391
SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

COVID-19 booster immunizations aimed at spike protein from new SARS-CoV-2 variants induce robust germinal centre B cell responses against the original spike protein, as well as de novo B cell responses against the variant spike protein.

Wafaa B. Alsoussi
Sameer Kumar Malladi
Ali H. Ellebedy
Research03 Apr 2023
Nature

Volume: 617, P: 592-598
Broadly neutralizing antibodies target a haemagglutinin anchor epitope

A distinct class of broadly neutralizing antibodies to the influenza virus target a membrane-proximal anchor epitope of the haemagglutinin stalk ___domain.

Jenna J. Guthmiller
Julianna Han
Patrick C. Wilson
ResearchOpen Access23 Dec 2021
Nature

Volume: 602, P: 314-320
A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

New influenza virus vaccines tested in humans elicit broadly cross-reactive antibodies that bind the stalk of the viral hemagglutinin protein and may serve as templates to design a universal influenza vaccine.

Raffael Nachbagauer
Jodi Feser
Florian Krammer
Research07 Dec 2020
Nature Medicine

Volume: 27, P: 106-114
Novel correlates of protection against pandemic H1N1 influenza A virus infection

Study of influenza virus transmission in humans provides evidence that hemagglutinin stalk-specific antibodies correlate with protection from infection.

Sophia Ng
Raffael Nachbagauer
Aubree Gordon
Research03 Jun 2019
Nature Medicine

Volume: 25, P: 962-967
A cross-reactive mouse monoclonal antibody against rhinovirus mediates phagocytosis in vitro

Mohammad Amin Behzadi
Angela Choi
Raffael Nachbagauer
ResearchOpen Access16 Jun 2020
Scientific Reports

Volume: 10, P: 1-10
Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins

Antigenic drift and reassortment alters the epitopes of influenza virus. Krammer and colleagues reveal the cross-reactivity of antibody responses to viral hemagglutinin and neuraminidase in humans and several animal models, but the most prominent responses reflect ‘original antigenic sin’ to viral exposure.

Raffael Nachbagauer
Angela Choi
Florian Krammer
Research13 Feb 2017
Nature Immunology

Volume: 18, P: 464-473
AS03-adjuvanted H7N9 inactivated split virion vaccines induce cross-reactive and protective responses in ferrets

Daniel Stadlbauer
Leon de Waal
Corey P. Mallett
ResearchOpen Access19 Mar 2021
npj Vaccines

Volume: 6, P: 1-10
A mosaic hemagglutinin-based influenza virus vaccine candidate protects mice from challenge with divergent H3N2 strains

Felix Broecker
Sean T. H. Liu
Peter Palese
ResearchOpen Access19 Jul 2019
npj Vaccines

Volume: 4, P: 1-9
A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies

Raffael Nachbagauer
Wen-Chun Liu
Florian Krammer
ResearchOpen Access14 Sept 2017
npj Vaccines

Volume: 2, P: 1-13
A chimeric haemagglutinin-based influenza split virion vaccine adjuvanted with AS03 induces protective stalk-reactive antibodies in mice

Raffael Nachbagauer
David Kinzler
Florian Krammer
ResearchOpen Access22 Sept 2016
npj Vaccines

Volume: 1, P: 1-10

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Immunogenicity and safety of mRNA-based seasonal influenza vaccines encoding hemagglutinin and neuraminidase

Pandemic influenza virus vaccines boost hemagglutinin stalk-specific antibody responses in primed adult and pediatric cohorts

Safety and immunogenicity of a phase 1/2 randomized clinical trial of a quadrivalent, mRNA-based seasonal influenza vaccine (mRNA-1010) in healthy adults: interim analysis

Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial

SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

Broadly neutralizing antibodies target a haemagglutinin anchor epitope

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

Novel correlates of protection against pandemic H1N1 influenza A virus infection

A cross-reactive mouse monoclonal antibody against rhinovirus mediates phagocytosis in vitro

Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins

AS03-adjuvanted H7N9 inactivated split virion vaccines induce cross-reactive and protective responses in ferrets

A mosaic hemagglutinin-based influenza virus vaccine candidate protects mice from challenge with divergent H3N2 strains

A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies

A chimeric haemagglutinin-based influenza split virion vaccine adjuvanted with AS03 induces protective stalk-reactive antibodies in mice

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