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Nature Cell Biology (2)
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Showing 1–5 of 5 results

Advanced filters: Author: Raffaele Nicastro Clear advanced filters

Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor

Nicastro, Brohée et al. find that the fatty acid synthesis intermediate malonyl-CoA inhibits mTORC1, showing mTORC1 senses the capacity of a cell to synthesise fatty acids and linking fatty acid generation with the overall biosynthetic output through mTORC1.

Raffaele Nicastro
Laura Brohée
Constantinos Demetriades
ResearchOpen Access10 Aug 2023
Nature Cell Biology

Volume: 25, P: 1303-1318
Spermidine is essential for fasting-mediated autophagy and longevity

Hofer et al. show that fasting promotes the synthesis of spermidine, which stimulates eIF5A hypusination to induce autophagy and increase lifespan in various species in a conserved manner.

Sebastian J. Hofer
Ioanna Daskalaki
Frank Madeo
ResearchOpen Access08 Aug 2024
Nature Cell Biology

Volume: 26, P: 1571-1584
Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Julien Barc
Rafik Tadros
Connie R. Bezzina
Amendments and Corrections26 Apr 2022
Nature Genetics

Volume: 54, P: 735
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Genome-wide association analyses identify new susceptibility loci for Brugada syndrome. Functional studies implicate microtubule-related trafficking effects on sodium channel expression as an underlying molecular mechanism.

Julien Barc
Rafik Tadros
Connie R. Bezzina
Research24 Feb 2022
Nature Genetics

Volume: 54, P: 232-239
TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1

Marta Moreno-Torres
Malika Jaquenoud
Claudio De Virgilio
ResearchOpen Access02 May 2017
Cell Discovery

Volume: 3, P: 1-12