Nature Search

Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects

GWASs based on self-reported phenotypes in 736,723 individuals show distinct associations between risk loci and eight COVID-19 outcomes, suggesting differences in genetic susceptibility to infection upon exposure and severe and symptomatic disease.

Genevieve H. L. Roberts
Raghavendran Partha
Kristin A. Rand
Research11 Apr 2022
Nature Genetics

Volume: 54, P: 374-381
Genetic risk factors for COVID-19 and influenza are largely distinct

Genome-wide analyses identify variants in B3GALT5 and ST6GAL1 associated with influenza susceptibility. Knockdown of ST6GAL1 in cell culture reduces influenza infectivity, likely by interfering with the glycoprotein modifications required for viral entry.

Jack A. Kosmicki
Anthony Marcketta
Manuel A. R. Ferreira
ResearchOpen Access05 Aug 2024
Nature Genetics

Volume: 56, P: 1592-1596
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease

Genome-wide meta-analysis of SARS-CoV-2 susceptibility and severity phenotypes in up to 756,646 samples identifies a rare protective variant proximal to ACE2. A 6-SNP genetic risk score provides additional predictive power when added to known risk factors.

Julie E. Horowitz
Jack A. Kosmicki
Manuel A. R. Ferreira
ResearchOpen Access03 Mar 2022
Nature Genetics

Volume: 54, P: 382-392
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A first update on mapping the human genetic architecture of COVID-19

Gita A. Pathak
Juha Karjalainen
J. Kenneth Baillie
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: E1-E10

Search

Filter By:

Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects

Genetic risk factors for COVID-19 and influenza are largely distinct

Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease

Mapping the human genetic architecture of COVID-19

Whole-genome sequencing reveals host factors underlying critical COVID-19

A first update on mapping the human genetic architecture of COVID-19

Search

Quick links