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Antibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses

The preferential susceptibility of oncolytic viruses to certain antibiotics can be exploited to accelerate the engineering of oncolytic viruses expressing transgenes for immunomodulatory cytokines.

Reza Rezaei
Stephen Boulton
Taha Azad
Research28 Nov 2024
Nature Biomedical Engineering

Volume: 9, P: 822-835
Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy

RNA-based viruses can be engineered to express artificial microRNAs (amiRNAs). Here, the authors identify a candidate amiRNA that confers a replicative advantage to oncolytic viruses, enhancing their anticancer potency, and show that intercellular transfer of extracellular vesicles carrying the amiRNA promotes bystander killing of uninfected cancer cells.

Marie-Eve Wedge
Victoria A. Jennings
Carolina S. Ilkow
ResearchOpen Access07 Apr 2022
Nature Communications

Volume: 13, P: 1-16
Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies

The large coding potential of vaccinia virus (VV) vectors is a defining feature. Here the authors present vaccinia virus vector-adapted chemogenetic switches enabling temporal and dose control of viral replication and transgene expression, implementation of complex tunable transgene circuitry, and generation of safer, more efficacious vectors.

Taha Azad
Reza Rezaei
John C. Bell
ResearchOpen Access26 May 2023
Nature Communications

Volume: 14, P: 1-18
MicroRNAs regulate the immunometabolic response to viral infection in the liver

25-Hydroxycholesterol induces expression of the microRNAs miR-130b and miR-185 in HCV-infected cells, and these inhibit viral fatty acid desaturation, lipid uptake and biosynthesis, thereby limiting infection. HCV counteracts this immunometabolic response by downregulating these microRNAs.

Ragunath Singaravelu
Shifawn O'Hara
John Paul Pezacki
Research19 Oct 2015
Nature Chemical Biology

Volume: 11, P: 988-993
Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy

The nonlinear variant of Raman spectroscopy, coherent anti-Stokes Raman scattering (CARS) microscopy, combines powerful Raman signal enhancement with several other advantages such as label-free detection and has been used to image various cellular processes including host-pathogen interactions and lipid metabolism.

John Paul Pezacki
Jessie A Blake
Ragunath Singaravelu
Reviews14 Feb 2011
Nature Chemical Biology

Volume: 7, P: 137-145
MicroRNA-7 mediates cross-talk between metabolic signaling pathways in the liver

Ragunath Singaravelu
Curtis Quan
John P. Pezacki
ResearchOpen Access10 Jan 2018
Scientific Reports

Volume: 8, P: 1-10
Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes

Rodney K. Lyn
Ragunath Singaravelu
John Paul Pezacki
ResearchOpen Access01 Apr 2014
Scientific Reports

Volume: 4, P: 1-11

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Antibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses

Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies

MicroRNAs regulate the immunometabolic response to viral infection in the liver

Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy

MicroRNA-7 mediates cross-talk between metabolic signaling pathways in the liver

Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes

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