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Nature Immunology (3)

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Cancer
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Author Correction: PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1⁺CD38^hi cells and anti-PD-1 resistance

Vivek Verma
Rajeev K Shrimali
Samir N. Khleif
Amendments and Corrections24 Sept 2019
Nature Immunology

Volume: 20, P: 1555
MEK inhibition reprograms CD8⁺ T lymphocytes into memory stem cells with potent antitumor effects

Stem cell–like memory (T_SCM) CD8⁺ T cells are beneficial in antitumor responses, in part due to their ability to self-renew. Khleif and colleagues demonstrate that inhibition of the kinase MEK in CD8⁺ T cells favors induction of T_SCM and superior antitumor responses.

Vivek Verma
Nazli Jafarzadeh
Samir N. Khleif
Research23 Nov 2020
Nature Immunology

Volume: 22, P: 53-66
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1⁺CD38^hi cells and anti-PD-1 resistance

PD-1 blockade can enhance antitumor responses in a subset of cases. Khleif and colleagues demonstrate that PD-1 blockade in the context of suboptimal T cell activation engenders a state of non-responsiveness but not when there is strong stimulation by vaccination.

Vivek Verma
Rajeev K Shrimali
Samir N. Khleif
Research29 Jul 2019
Nature Immunology

Volume: 20, P: 1231-1243

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Author Correction: PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance

MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects

PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance

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Author Correction: PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1⁺CD38^hi cells and anti-PD-1 resistance

MEK inhibition reprograms CD8⁺ T lymphocytes into memory stem cells with potent antitumor effects

PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1⁺CD38^hi cells and anti-PD-1 resistance