Nature Search

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κB signaling

Rainer Döffinger
Asma Smahi
Jean-Laurent Casanova
Research01 Mar 2001
Nature Genetics

Volume: 27, P: 277-285
Age-associated defect in ADCC response to COVID-19 vaccine

Benjamin L. Sievers
Mazharul Altaf
Ravindra K. Gupta
ResearchOpen Access01 Jul 2025
npj Vaccines

Volume: 10, P: 1-9
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Inborn errors of the alternative NF-κB pathway in humans impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases

Tom Le Voyer
Audrey V. Parent
Anne Puel
ResearchOpen Access08 Nov 2023
Nature

Volume: 623, P: 803-813
Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade

Age-associated B cells (ABC) have been shown to be associated with autoimmunity and ageing. Here the authors examine whether ABC are transcriptionally or functionally altered in participants with reduced immune cell function and show that, being transcriptionally similar, high pre-vaccine levels are associated with poor vaccine response.

Juan Carlos Yam-Puc
Zhaleh Hosseini
James E. D. Thaventhiran
ResearchOpen Access27 Jun 2023
Nature Communications

Volume: 14, P: 1-14
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Accelerated waning of the humoral response to COVID-19 vaccines in obesity

Epidemiological analyses coupled with immunological phenotyping suggest that humoral immunity induced by COVID-19 vaccines wanes more rapidly in individuals with severe obesity compared to individuals with a BMI within the normal range.

Agatha A. van der Klaauw
Emily C. Horner
James E. D. Thaventhiran
ResearchOpen Access11 May 2023
Nature Medicine

Volume: 29, P: 1146-1154
SARS-COV-2 antibody responses to AZD1222 vaccination in West Africa

Data on immune response to the SARS-COV-2 AZD1222 vaccine are limited in African populations. Here, the authors show immunogenicity of the AZD1222 vaccine in two independent cohorts from West Africa, including seroprevalence levels prior to vaccine rollout in January 2021.

Adam Abdullahi
David Oladele
Ravindra K. Gupta
ResearchOpen Access17 Oct 2022
Nature Communications

Volume: 13, P: 1-11
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

The spike protein of the Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 than Delta, and a marked change in its antigenicity increases Omicron’s evasion of therapeutic and vaccine-elicited neutralizing antibodies.

Bo Meng
Adam Abdullahi
Ravindra K. Gupta
ResearchOpen Access01 Feb 2022
Nature

Volume: 603, P: 706-714
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

Individuals over eighty years of age are less likely to mount a good immune response against SARS-CoV-2 (measured by neutralization titres) after the first dose of the BNT162b2 mRNA vaccine, but achieve good neutralization after the second dose.

Dami A. Collier
Isabella A. T. M. Ferreira
Ravindra K. Gupta
ResearchOpen Access30 Jun 2021
Nature

Volume: 596, P: 417-422
Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report

Remdesivir is under evaluation for treatment of COVID-19 in clinical trials. Here, the authors report results of remdesivir treatment in a patient with COVID-19 and the genetic antibody deficiency XLA. They show a temporally correlated clinical and virological response, suggesting that remdesivir can reduce SARS-CoV-2 replication in patients.

Matthew S. Buckland
James B. Galloway
James E. D. Thaventhiran
ResearchOpen Access14 Dec 2020
Nature Communications

Volume: 11, P: 1-11
A thermostable, closed SARS-CoV-2 spike protein trimer

The SARS-CoV-2 spike glycoprotein is flexible, and its receptor-binding ___domain (RBD) fluctuates between open and closed conformations. Disulfide bonds are engineered into the spike ectodomain to lock the RBD in the closed state, leading to a construct with high thermostability.

Xiaoli Xiong
Kun Qu
John A. G. Briggs
Research31 Jul 2020
Nature Structural & Molecular Biology

Volume: 27, P: 934-941
Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses

Salt levels in culture affect the polarisation of Th17 cells, which normally protect the host from fungal and bacterial infections. Here, the authors study patients with salt-losing tubulopathies (SLT) to find that, while Th17 immunity is dampened in SLT patients, their Th17-inducing signaling pathways are intact and can be reinvigorated by exogenous salt.

Rhys D. R. Evans
Marilina Antonelou
Alan D. Salama
ResearchOpen Access31 Aug 2020
Nature Communications

Volume: 11, P: 1-19
A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection

Emmanuelle Jouanguy
Salma Lamhamedi-Cherradi
Jean-Laurent Casanova
Research01 Apr 1999
Nature Genetics

Volume: 21, P: 370-378
Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection

JAK1 mediates intracellular signalling from multiple cytokine receptors. Here, Elettoet al. identify JAK1 mutations that disrupt multiple signalling pathways and are associated with primary immunodeficiency, atypical mycobacterial infection susceptibility and early-onset metastatic bladder carcinoma.

Davide Eletto
Siobhan O. Burns
Sergey Nejentsev
ResearchOpen Access23 Dec 2016
Nature Communications

Volume: 7, P: 1-12
The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

Immunoglobulin class-switch recombination can be induced by the secreted factors BAFF and APRIL. Cerutti and colleagues show that the receptor TACI conveys such signals via the adaptor MyD88 to induce class-switch recombination.

Bing He
Raul Santamaria
Andrea Cerutti
Research01 Aug 2010
Nature Immunology

Volume: 11, P: 836-845
Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Research06 May 2020
Nature

Volume: 583, P: 90-95
Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host

Mutation of a mismatch repair gene accelerated the genomic mutation rate of Salmonella Enteritidis infecting an immunocompromized individual, leading to levels of evolution that parallel those found in successful host-restricted bacterial pathogens.

Elizabeth J. Klemm
Effrossyni Gkrania-Klotsas
Robert A. Kingsley
Research25 Jan 2016
Nature Microbiology

Volume: 1, P: 1-6
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Amendments and Corrections17 Jul 2020
Nature

Volume: 584, P: E2
Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
ResearchOpen Access22 Jan 2018
Scientific Reports

Volume: 8, P: 1-17
Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
Amendments and CorrectionsOpen Access03 Sept 2018
Scientific Reports

Volume: 8, P: 1-4

Search

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κB signaling

Age-associated defect in ADCC response to COVID-19 vaccine

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade

SARS-CoV-2 evolution during treatment of chronic infection

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Accelerated waning of the humoral response to COVID-19 vaccines in obesity

SARS-COV-2 antibody responses to AZD1222 vaccination in West Africa

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report

A thermostable, closed SARS-CoV-2 spike protein trimer

Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses

A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection

Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection

The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host

Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

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