Search

Ouyang et al. present LassoPred, a computational tool to accurately predicts the 3D structure of lasso peptides and offers an accessible online prediction tool to the scientific community.

Complex traits present challenges for gene mapping and molecular characterization. Here, the authors develop a 16-generation intercross line of chickens to explore the genetic architecture of complex traits in chicken.

Proteome profiling of plasma samples in human pan-cancer cohorts reveals patterns of biomarkers for diagnosis.

‘Small cell lung cancers do not respond well to immune checkpoint blockade therapy, due to the poor recruitment of CD8 + T cells to the tumours. Here authors show that via combining radiotherapy, PARP inhibitors and anti-PD-L1 treatments, T cell infiltration and function could be improved via mechanisms that increase the chemo-attractants CCL5 and CXCL10.

Lan et al. demonstrate the high performance of plasma p-tau217 in detecting and tracking multiple aspects of Alzheimer’s disease pathology, outperforming other plasma tau biomarkers across two Chinese cohorts (GHABS and Huashan) and the North American ADNI cohort.

Lysosomal function depends upon calcium homeostasis. Here, using a novel sensor for perilysosomal pH and lysosomal proton efflux, Chen et al. identify lysosomal TMEM165 as a mediator of the calcium-activated lysosomal proton leak.

Here, Ying Li et al. present the results of a randomized controlled feeding trial in prediabetes participants, finding that advancing timing of unsaturated fat (USFA) intake improves insulin sensitivity through the gut microbiome and bile acid metabolism, regardless of USFA type.

Chirality-induced quantum non-reciprocity of cross-channel correlations is demonstrated in a rubidium vapour system by flipping the flow direction of one of the circularly polarized laser beams. It can be extended to multicolour sidebands with Floquet engineering.

The MmpL5/MmpS5 efflux system is crucial for drug extrusion and siderophore export in M. tuberculosis. Here, the authors report its high-resolution cryo-EM structures, revealing a unique trimeric assembly and a flexible extracellular stalk.

Here the authors uncover an epigenetic mechanism regulating pancreatic β-cell adaptation during pregnancy in mice involving ACSS2 and STAT3 coordinated histone acetylation. These findings provide clues into gestational diabetes mechanisms and potential therapeutic targets.

A study finds that RUVBL2 is a conserved component of eukaryotic circadian clocks and suggests that slow ATPase activity, which was initially discovered in cyanobacteria, is a shared feature of eukaryotic clocks.

A ketogenic diet and the ketone body β-hydroxybutyrate are shown to confer resistance to malaria in mice by inducing metabolic reprogramming in Plasmodium parasites, suggesting a dietary strategy for malaria prevention.

Modulating room-temperature phosphorescence requires regulating energy and coupling of electronic states. Here the authors show how pressure blue-shifts and enhances emission in molecular crystals by inducing atomic orbital sharing of iodine atoms.

Glioma is a complex disease, and prognosis can depend on clinical, genomic and radiological information. Here, the authors develop a multimodal fusion subtyping model to integrate data modalities for predicting glioma subtypes.

The authors provide experimental evidence for giant polarization in wurtzite III-nitrides, establishing a unified framework for understanding and engineering polarization in these materials and their functional device architectures.

Absorption and accumulation of atmospheric microplastics by plant leaves occurs widely in the environment.

Developing skeletal editing tools, especially to realize the single-atom transmutation in a ring system without altering the ring size is challenging. Here, the authors introduce a skeletal editing strategy that enables polycyclic arenols to be readily converted into N-heteroarenes through carbon–nitrogen transmutation.

The construction of atropisomers with 1,2-diaxes, while maintaining high enantiocontrol, presents a significant challenge due to the dynamic nature of steric hindrance at ortho-aryl substituents. Herein, the authors report the synthesis of diverse atropisomeric arylpyrroles with 1,2-diaxes, and C–C and C–N axes via a remote stereocontrol strategy.

Single-crystal Ni-rich cathode materials are highly sought after in battery development. In this study the authors present a synthesis route that leverages Li₂O sublimation to facilitate the production of high-performance single-crystal cathode materials.

How GWAS-annotated noncoding SNPs contribute to diabetes remains unclear. Here, the authors report that the noncoding SNP rs6048205 drives stage-specific defects in human pancreatic differentiation and increases diabetes susceptibility in mice.

In this Review, Ferretti et al. discuss advances in our understanding of interactions between the human genome and the microbiome, including the effects of the microbiome on host gene regulation.

Dense calcium imaging combined with co-registered high-resolution electron microscopy reconstruction of the brain of the same mouse provide a functional connectomics map of tens of thousands of neurons of a region of the primary cortex and higher visual areas.

The drying out of the Aral Sea has induced flow of the relatively weak asthenosphere beneath, demonstrating that human activity can influence mantle dynamics, according to numerical simulations of ground uplift measured by radar interferometry.

The dynamic kinetic asymmetric C−O cross-coupling has presented significant challenges and remains unexplored. Here, the authors report the dynamic kinetic asymmetric C−O cross-coupling of oximes and phenols via copper/BOX-catalysed enantioselective O-arylation with diaryliodonium salts.

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

IgA nephropathy is a major cause of end-stage renal disease in China, occurring at a high frequency in Asian populations. Here Li and colleagues conduct a four-stage genome-wide association study in a Chinese population, identifying novel loci and variants associated with disease risk.

The molecular characterisation of soft tissue sarcomas (STSs) across diverse populations remains crucial. Here, the authors perform a proteomics and phosphoproteomics analysis of 272 Chinese STS patients across 12 subtypes, and obtain insights related to progression, metastasis, and immune signatures.

Gluconeogenesis produces glucose from non-carbohydrate carbon substrates, particularly occurs during fasting. Here, the authors show lysine methyltransferase KMT5C promotes gluconeogenesis by decreasing PGC-1α degradation, which is independent of its methyltransferase activity.

Non-intrusive integration of metasurfaces with vertical cavity surface-emitting lasers enables fully arbitrary wavefront control for directional laser emission.

Molecular design is key to the power conversion efficiency in organic photovoltaics. Jiang, Sun, Xu et al. develop a non-fullerene acceptor with asymmetric structure and phenyl-substituted side chains that minimizes photon and carrier losses, enabling 20.2% efficiency.

Psoriasis is a skin disease associated with neurogenic inflammation. Here, the authors activation of ASIC3 on sensory neurons that leads to the release of CGRP, which triggers inflammation through dendritic cells and drives psoriatic inflammation.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

Fabricating semiconductor devices with dimensions below 10 nm presents significant challenges. Here, Liu et al. use controlled electron irradiation to remove atoms in an MoS₂ sheet, creating Mo₅S₄nanoribbons with a uniform width of 0.35 nm and a theoretical band gap of 0.77 eV.

Histamine receptor, a typical G-protein-coupled receptor (GPCR), is important mediator of signalling and is responsible for regulation of human autoimmunity. Here, the authors report an artificial model to mimic the wettability-induced activation of natural GPCRs via histamine-modulated enhancement of wettability in a bionic nanochannel.

ARF4 GTPase activity is needed for vesicular trafficking for multiple RNA viruses. Blocking ARF4 using specific peptides redirects viral progeny to lysosomal degradation and decreases influenza and Zika virus infection in mice.

Renal cell carcinoma consists of several subtypes, and recurrence is highly dependent on subtype. Here, the authors develop a multi-classifier using imaging, lncRNA and clinical data to predict recurrence in papillary renal cell carcinoma.

The targeted epigenetic repression of a β₂-microglobulin super-enhancer downregulates the expression of human leucocyte antigens on mesenchymal stromal cells, making the cells suitable for allogeneic cell therapy.

Moderate disorder can induce topologically nontrivial phases. Liu et al. report the experimental observations of the competition and interplay between Thouless pumping and disorder on a 41-qubit superconducting quantum processor.

Superoxide dismutase 3 is elevated in patients and animals infected by protozoan parasites such as Plasmodium. Here, Li et al. show that SOD3 expression is associated with experimental cerebral malaria and inhibition of host immune responses.

Constructing two-dimensional (2D) polymers with complex tessellation patterns is important for the fabrication of advanced materials but achieving such complexity is a great challenge. Here the authors report a tessellated 2D covalent organic framework with increased structural complexity as well as different pore structures.

A large bulk photovoltaic effect is observed in the type-I Weyl semimetal TaAs, and attributed to the diverging Berry curvature of the Weyl nodes.