Nature Search

Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver

Jeffrey H Albrecht
Randy YC Poon
Gretchen S Crary
Research30 Apr 1998
Oncogene

Volume: 16, P: 2141-2150
System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans

Pulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccines induce durable immunity.

Mario Cortese
Thomas Hagan
Bali Pulendran
Research02 Jan 2025
Nature Immunology

Volume: 26, P: 116-130
Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome

Haixu Chen
Yi Lun
Randy L. Johnson
Research01 May 1998
Nature Genetics

Volume: 19, P: 51-55
A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies

Raffael Nachbagauer
Wen-Chun Liu
Florian Krammer
ResearchOpen Access14 Sept 2017
npj Vaccines

Volume: 2, P: 1-13
Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets

Using a multi-OMICS approach, Haas et al identify 54 human genes and 16 host-targeting chemical compounds that regulate influenza A virus infection in lung epithelial cells, including AHNAK and COBP1 which are also essential for SARS-CoV-2 infection.

Kelsey M. Haas
Michael J. McGregor
Nevan J. Krogan
ResearchOpen Access27 Sept 2023
Nature Communications

Volume: 14, P: 1-27
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

A microfluidic bronchial-airway-on-a-chip lined by human bronchial-airway epithelium and pulmonary endothelium can be used to rapidly identify antiviral therapeutics and prophylactics with repurposing potential.

Longlong Si
Haiqing Bai
Donald E. Ingber
Research03 May 2021
Nature Biomedical Engineering

Volume: 5, P: 815-829
Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection

Influenza A virus (IAV) infection can be exacerbated by bacterial co-infections but the effect of IAV on the upper respiratory tract (URT) microbiome remains unclear. Here, the authors compare the dynamics of the UTR microbiome in IAV-infected ferrets and humans, finding similar trends at the ecosystem and individual taxon level in both hosts.

Drishti Kaul
Raveen Rathnasinghe
Rafael A. Medina
ResearchOpen Access21 May 2020
Nature Communications

Volume: 11, P: 1-12
MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies

A strategy exploiting species-specific miRNA expression may provide another layer of biosafety in gain-of-function influenza experiments.

Ryan A Langlois
Randy A Albrecht
Benjamin R tenOever
Research11 Aug 2013
Nature Biotechnology

Volume: 31, P: 844-847
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

A screen of the ReFRAME library of approximately 12,000 known drugs for antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) identified several candidate compounds with suitable activities and pharmacological profiles, which could potentially expedite the deployment of therapies for coronavirus disease 2019 (COVID-19).

Laura Riva
Shuofeng Yuan
Sumit K. Chanda
Research24 Jul 2020
Nature

Volume: 586, P: 113-119
Influenza virus infection causes global RNAPII termination defects

Influenza A virus (IAV) infection induces transcription termination defects in host cells, an effect modulated by SUMOylation of an intrinsically disordered region of the influenza NS1 protein expressed by the 1918 pandemic IAV strain.

Nan Zhao
Vittorio Sebastiano
Ivan Marazzi
Research03 Sept 2018
Nature Structural & Molecular Biology

Volume: 25, P: 885-893
Suppression of the antiviral response by an influenza histone mimic

The H3N2 influenza virus immunomodulatory protein NS1 carries a sequence that mimics the histone H3 tail; this sequence interferes with the host antiviral response via binding to the cellular regulator of RNA elongation, hPAF1C.

Ivan Marazzi
Jessica S. Y. Ho
Alexander Tarakhovsky
Research14 Mar 2012
Nature

Volume: 483, P: 428-433
Author Correction: Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection

Drishti Kaul
Raveen Rathnasinghe
Rafael A. Medina
Amendments and CorrectionsOpen Access16 Jun 2020
Nature Communications

Volume: 11, P: 1
A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA

Broadly neutralizing antibodies are potential therapeutics and can aid rational vaccine development. Here, the authors show that the human monoclonal antibody H3v-47 recognizes a highly conserved epitope in HA of H3N2 viruses, inhibits virus replication by blocking egress and other mechanisms, and protects mice from disease.

Sandhya Bangaru
Heng Zhang
James E. Crowe Jr.
ResearchOpen Access10 Jul 2018
Nature Communications

Volume: 9, P: 1-15
Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death

The differences in virus-host interactions resulting in distinct pathogenicity of seasonal and pandemic influenza A viruses (IAV) are not well understood. Here, the authors show that the hemagglutinin segment from pandemic, but not seasonal, IAV suppresses RIPK3-mediated dendritic cell death, thereby reducing T cell activation.

Boris M. Hartmann
Randy A. Albrecht
Stuart C. Sealfon
ResearchOpen Access05 Dec 2017
Nature Communications

Volume: 8, P: 1-13
ICOS⁺PD-1⁺CXCR3⁺ T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination

Salah-Eddine Bentebibel
Surender Khurana
Hideki Ueno
ResearchOpen Access27 May 2016
Scientific Reports

Volume: 6, P: 1-8
Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy

Multi-omics analysis of influenza A virus cellular restriction in human macrophage-like cells reveals a mechanism for viral evasion of autophagy.

Laura Martin-Sancho
Shashank Tripathi
Sumit K. Chanda
Research23 Sept 2021
Nature Microbiology

Volume: 6, P: 1319-1333
Sequential immunization with chimeric hemagglutinin ΔNS1 attenuated influenza vaccines induces broad humoral and cellular immunity

Raveen Rathnasinghe
Lauren A. Chang
Adolfo García-Sastre
ResearchOpen Access16 Sept 2024
npj Vaccines

Volume: 9, P: 1-17
Programming the magnitude and persistence of antibody responses with innate immunity

Here it is shown that nanoparticles containing two Toll-like receptor ligands can boost the magnitude and persistence of vaccine-elicited antibody responses in primates, improving vaccine-mediated protection against influenza virus.

Sudhir Pai Kasturi
Ioanna Skountzou
Bali Pulendran
Research23 Feb 2011
Nature

Volume: 470, P: 543-547
Expression of a novel form of p21^Cip1/Waf1 in UV-irradiated and transformed cells

Randy YC Poon
Tony Hunter
Research19 Mar 1998
Oncogene

Volume: 16, P: 1333-1343
Animal models for COVID-19

The findings of a World Health Organization expert working group that is developing animal models to test vaccines and therapeutic agents for the treatment of COVID-19, and their relevance for preclinical testing, are reviewed.

César Muñoz-Fontela
William E. Dowling
Dan H. Barouch
Reviews23 Sept 2020
Nature

Volume: 586, P: 509-515
Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins

Antigenic drift and reassortment alters the epitopes of influenza virus. Krammer and colleagues reveal the cross-reactivity of antibody responses to viral hemagglutinin and neuraminidase in humans and several animal models, but the most prominent responses reflect ‘original antigenic sin’ to viral exposure.

Raffael Nachbagauer
Angela Choi
Florian Krammer
Research13 Feb 2017
Nature Immunology

Volume: 18, P: 464-473
Pandemic influenza virus vaccines boost hemagglutinin stalk-specific antibody responses in primed adult and pediatric cohorts

Raffael Nachbagauer
Bruno Salaun
Carine Claeys
ResearchOpen Access06 Dec 2019
npj Vaccines

Volume: 4, P: 1-12
Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience

Clare Bryce
Zachary Grimes
Mary E. Fowkes
Research01 Apr 2021
Modern Pathology

Volume: 34, P: 1456-1467

Search

Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver

System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans

Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome

A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies

Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection

MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

Influenza virus infection causes global RNAPII termination defects

Suppression of the antiviral response by an influenza histone mimic

Author Correction: Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection

A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA

Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death

ICOS⁺PD-1⁺CXCR3⁺ T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination

Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy

Sequential immunization with chimeric hemagglutinin ΔNS1 attenuated influenza vaccines induces broad humoral and cellular immunity

Programming the magnitude and persistence of antibody responses with innate immunity

Expression of a novel form of p21^Cip1/Waf1 in UV-irradiated and transformed cells

Animal models for COVID-19

Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins

Pandemic influenza virus vaccines boost hemagglutinin stalk-specific antibody responses in primed adult and pediatric cohorts

Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience

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