Here, the authors use gnotobiotic mice to show that three core species of the human infant gut mycobiome (Rhodotorula mucilaginosa, Malassezia restricta and Candida albicans) exert distinct modulatory effects on the gut microbiome and immune landscape in white adipose tissue, with R. mucilaginosa and M. restricta increasing adiposity and exacerbating metabolic disease, while C. albicans resulted in leanness and resistance to diet-induced obesity.
- Mackenzie W. Gutierrez
- Erik van Tilburg Bernardes
- Marie-Claire Arrieta
