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Showing 1–7 of 7 results
Advanced filters: Author: Reza Vafabakhsh Clear advanced filters

  • Adhesion GPCRs play a key role in cellular communication. Here, the authors use cryo-EM and single-molecule FRET to map the conformational changes between the extracellular and transmembrane domains of Latrophilin3/ADGRL3, offering new insights into receptor activation.

    • Szymon P. Kordon
    • Kristina Cechova
    • Demet Araç
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Single-molecule FRET of mGluR2 shows that the conformations of the ligand-binding ___domain and the linked cysteine-rich ___domain are loosely coupled during ligand-induced activation and defines two pre-active states linking inactive and active states.

    • Brandon Wey-Hung Liauw
    • Hamid Samareh Afsari
    • Reza Vafabakhsh
    Research
    Nature Chemical Biology
    Volume: 17, P: 291-297

  • Single-molecule FRET provides insight into the structural dynamics of the KirBac1.1 potassium channel and reveals that channel gating is controlled by the tightness of the slide-helix ‘belt’.

    • Shizhen Wang
    • Reza Vafabakhsh
    • Colin G Nichols
    Research
    Nature Structural & Molecular Biology
    Volume: 23, P: 31-36

  • smFRET is used to probe the activation mechanism of two full-length mammalian glutamate receptors, revealing that the extracellular ligand-binding domains of these G-protein-coupled receptors interconvert between three confirmations (resting, activated and a short-lived intermediate state), and that the efficacy of an orthosteric agonist correlates with the degree of occupancy of the active state.

    • Reza Vafabakhsh
    • Joshua Levitz
    • Ehud Y. Isacoff
    Research
    Nature
    Volume: 524, P: 497-501

  • In viruses, multi-subunit ring-ATPases are involved in genome packaging. Here, using single-molecule techniques, the authors determine that the active bacteriophage T4 DNA packaging motor is a pentamer and show that the motor can tolerate inactive subunits, suggesting that strict coordination between the subunits is not crucial.

    • Li Dai
    • Digvijay Singh
    • Venigalla B. Rao
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • NMR and single molecule FRET experiments show that antiparallel EmrE dimers interconvert between two identical but oppositely oriented conformations that are each open only to one side of the membrane.

    • Emma A. Morrison
    • Gregory T. DeKoster
    • Katherine A. Henzler-Wildman
    Research
    Nature
    Volume: 481, P: 45-50