Nature Search

Frictiotaxis underlies focal adhesion-independent durotaxis

Cells typically migrate toward stiffer substrates via durotaxis, relying on focal adhesions. Here, the authors show that confined cells can migrate up friction gradients without focal adhesions, revealing a mode of directed migration called frictiotaxis.

Adam Shellard
Kai Weißenbruch
Roberto Mayor
ResearchOpen Access23 Apr 2025
Nature Communications

Volume: 16, P: 1-15
SNARE disassembly requires Sec18/NSF side loading

Khan et al. show that Sec18 uses both D1 and D2 AAA+ rings cooperatively, opening them laterally for SNARE substrate loading and for subsequent release of SNAREs.

Yousuf A. Khan
K. Ian White
Axel T. Brunger
ResearchOpen Access02 Jul 2025
Nature Structural & Molecular Biology

P: 1-13
The Somatic Mosaicism across Human Tissues Network

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Tim H. H. Coorens
Ji Won Oh
Yuqing Wang
Reviews02 Jul 2025
Nature

Volume: 643, P: 47-59
Structure of the ATP-dependent oligomerization ___domain of N-ethylmaleimide sensitive factor complexed with ATP

Richard C. Yu
Phyllis I. Hanson
Axel T. Brünger
Research01 Sept 1998
Nature Structural Biology

Volume: 5, P: 803-811
Early Homo erectus skeleton from west Lake Turkana, Kenya

Frank Brown
John Harris
Alan Walker
Research29 Aug 1985
Nature

Volume: 316, P: 788-792
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primary

Patients with metastatic cancers of unknown primary (CUP) are currently unable to gain access to drugs through standard of care or clinical trials. Here, the authors perform whole-genome and transcriptome sequencing (WGTS) on 72 patients with CUP and demonstrate the feasibility of using WGTS to determine the specific cancer types of CUP, thereby clinically benefiting patients with CUP.

Richard J. Rebello
Atara Posner
Richard W. Tothill
ResearchOpen Access20 May 2025
Nature Communications

Volume: 16, P: 1-15
Encephalization in Proconsul africanus (reply)

RICHARD SMITH
ALAN WALKER
Research17 May 1984
Nature

Volume: 309, P: 287-288
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
Single strands induce recA protein to unwind duplex DNA for homologous pairing

Richard P. Cunningham
Takehiko Shibata
Charles M. Radding
Research01 Sept 1979
Nature

Volume: 281, P: 191-195
Identification of undetected SARS-CoV-2 infections by clustering of Nucleocapsid antibody trajectories

Many SARS-CoV-2 infections may go undetected through conventional PCR or lateral flow tests. Here, the authors analyse the utility of analysing longitudinal nucleocapsid antibody trajectories to improve identification of prior SARS-CoV-2 infections using surveillance data from the UK.

Leslie R. Zwerwer
Tim E. A. Peto
Chris Cunningham
ResearchOpen Access14 May 2025
Nature Communications

Volume: 16, P: 1-13
New Histone Kinases in Nuclei of Rat Tissues

DONALD L. SMITH
BERNDT B. BRUEGGER
ROBERTS A. SMITH
Research09 Nov 1973
Nature

Volume: 246, P: 103-104
Fragments of eternal youth

Divided loyalties.

Richard A. Lovett
Comments & Opinion15 Nov 2024
Nature
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Ice Nucleation by α-Phenazine

RICHARD B. HEAD
Research24 Nov 1962
Nature

Volume: 196, P: 736-738
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Recurrent humid phases in Arabia over the past 8 million years

A climatic record from desert speleothems shows that the central Arabian interior experienced recurrent humid intervals over the past 8 million years, which likely facilitated mammalian dispersals between Africa and Eurasia.

Monika Markowska
Hubert B. Vonhof
Gerald H. Haug
ResearchOpen Access09 Apr 2025
Nature

Volume: 640, P: 954-961
Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway

The Cdc48 enzyme is an abundant and essential enzyme that functions in many cellular pathways as a protein unfoldase. Here, the authors determine an ensemble of Cdc48 structures that capture snapshots of its unfolding action using a ‘hand-over-hand’ mechanism.

Ian Cooney
Heidi L. Schubert
Peter S. Shen
ResearchOpen Access29 Aug 2024
Nature Communications

Volume: 15, P: 1-11
Complete genomic characterization of global pathogens respiratory syntical virus and human norovirus using probe based capture enrichment

Sravya V Bhamidipati
Anil Surathu
Harsha Doddapaneni
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

Sandra S. Strautnieks
Laura N. Bull
Richard J. Thompson
Research01 Nov 1998
Nature Genetics

Volume: 20, P: 233-238
Peripheral expansion of pre-existing mature T cells is an important means of CD4⁺ T-cell regeneration HIV-infected adults

Robert E. Walker
Charles S. Carter
H. Clifford Lane
Research01 Jul 1998
Nature Medicine

Volume: 4, P: 852-856
Reduction in SIV replication in rhesus macaques infused with autologous lymphocytes engineered with antiviral genes

Robert E. Donahue
Bruce A. Bunnell
Richard A. Morgan
Research01 Feb 1998
Nature Medicine

Volume: 4, P: 181-186
The COVIDTrach prospective cohort study on outcomes in 1982 tracheostomised COVID-19 patients during the first and second UK pandemic waves

Matthew Haywood
Gareth Ambler
Andrzej Sladkowski
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Greenhouse gases reduce the satellite carrying capacity of low Earth orbit

Satellites have become integral to our everyday life, but space debris threatens the sustainability of low Earth orbital space. Greenhouse gases are complicating the problem, leading to longer orbital retention of defunct satellites and increasing the risk of collision.

William E. Parker
Matthew K. Brown
Richard Linares
ResearchOpen Access10 Mar 2025
Nature Sustainability

Volume: 8, P: 363-372
Long arcuate fascicle in wild and captive chimpanzees as a potential structural precursor of the language network

The arcuate fascicle connection with the middle temporal gyrus has been considered unique to humans. Using high-resolution diffusion MRI, the authors systematically show this connection in chimpanzees, suggesting a gradual evolution of the language network.

Yannick Becker
Cornelius Eichner
Alfred Anwander
ResearchOpen Access15 May 2025
Nature Communications

Volume: 16, P: 1-9
Biological Sciences: Hydroxyguanidine—a New Antitumour Drug

RICHARD H. ADAMSON
Research21 Apr 1972
Nature

Volume: 236, P: 400-401
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Cutmarks made by stone tools on bones from Olduvai Gorge, Tanzania

Richard Potts
Pat Shipman
Research18 Jun 1981
Nature

Volume: 291, P: 577-580
A receptor subtype involved in neuropeptide-Y-induced food intake

Christophe Gerald
Mary W. Walker
Richard L. Weinshank
Research11 Jul 1996
Nature

Volume: 382, P: 168-171
Serum β₂-microglobulin binds to a T-cell differentiation antigen and increases its expression

Richard F. Kefford
Franco Calabi
Cesar Milstein
Research12 Apr 1984
Nature

Volume: 308, P: 641-642
A novel observational test of momentum balance in a solar flare

Richard C. Canfield
Thomas R. Metcalf
Dominic M. Zarro
Research01 Mar 1987
Nature

Volume: 326, P: 165-166
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

Zhishan Chen
Xingyi Guo
Wei Zheng
ResearchOpen Access26 Apr 2024
Nature Communications

Volume: 15, P: 1-17
The src gene product of transformed and morphologically reverted ASV-infected mammalian cells

Marc S. Collett
Joan S. Brugge
Anthony J. Faras
Research01 Sept 1979
Nature

Volume: 281, P: 195-198
Trust in scientists and their role in society across 68 countries

What is the state of trust in scientists around the world? To answer this question, the authors surveyed 71,922 respondents in 68 countries and found that trust in scientists is moderately high.

Viktoria Cologna
Niels G. Mede
Rolf A. Zwaan
ResearchOpen Access20 Jan 2025
Nature Human Behaviour

Volume: 9, P: 713-730
Origins and Evolution of Ornithischian Dinosaurs

RICHARD A. THULBORN
Research12 Nov 1971
Nature

Volume: 234, P: 75-78
Flandrian Strandline Chronology for the British Isles and Correlation of some European Postglacial Strandlines

RICHARD E. BINNS
Research28 Jan 1972
Nature

Volume: 235, P: 206-210
Novel Species of tRNA

THOMAS S. STEWART
RICHARD J. ROBERTS
JACK L. STROMINGER
Research05 Mar 1971
Nature

Volume: 230, P: 36-38
Neuromorphic scaling advantages for energy-efficient random walk computations

Neuromorphic hardware designed to implement spiking neural networks for deep learning and artificial intelligence applications can also be used to solve non-cognitive computational tasks such as Monte Carlo methods.

J. Darby Smith
Aaron J. Hill
James B. Aimone
Research14 Feb 2022
Nature Electronics

Volume: 5, P: 102-112
Multidecadal variability in East African hydroclimate controlled by the Indian Ocean

Proxy indicators of relative moisture balance, in combination with long control simulations from coupled climate models, show that the Indian Ocean drives multidecadal hydroclimate variability by altering the local Walker circulation, whereas the influence of the Pacific Ocean is minimal on these timescales.

Jessica E. Tierney
Jason E. Smerdon
Richard Seager
Research16 Jan 2013
Nature

Volume: 493, P: 389-392
Rabbit Antibody Light Chains and Gene Evolution

LEROY HOOD
KLAUS EICHMANN
JACK J. OHMS
Research12 Dec 1970
Nature

Volume: 228, P: 1040-1044
Creation of open universes from de Sitter space

J. Richard Gott III
Research28 Jan 1982
Nature

Volume: 295, P: 304-307
Measuring the relative importance of different pollinators to plants

RICHARD B. PRIMACK
JOHN A. SILANDER JR
Research08 May 1975
Nature

Volume: 255, P: 143-144
Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling

Protease containing ABC Transporters (PCAT) play a critical role in the translocation of polypeptides across membranes. Here, authors reveal the structural and energetic of the ATP-powered conformational cycle that enable this process.

Ruojing Zhang
Kevin L. Jagessar
Hassane S. Mchaourab
ResearchOpen Access20 Oct 2024
Nature Communications

Volume: 15, P: 1-15
Extinction of eastern Sahul megafauna coincides with sustained environmental deterioration

The causes of the Upper Pleistocene megafauna extinction in Australia and New Guinea are debated, but fossil data are lacking for much of this region. Here, Hocknull and colleagues report a new, diverse megafauna assemblage from north-eastern Australia that persisted until ~40,000 years ago.

Scott A. Hocknull
Richard Lewis
Rochelle A. Lawrence
ResearchOpen Access18 May 2020
Nature Communications

Volume: 11, P: 1-14
Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington’s disease

Microglia mediate the early and selective degeneration of corticostriatal synapses and the development of cognitive deficits in presymptomatic Huntington’s disease via the complement cascade.

Daniel K. Wilton
Kevin Mastro
Beth Stevens
ResearchOpen Access09 Oct 2023
Nature Medicine

Volume: 29, P: 2866-2884
The contribution of de novo coding mutations to meningomyelocele

Exome sequencing of 851 trios from more than 2,500 individuals finds 187 genes with de novo mutations that contribute to meningomyelocele (spina bifida) and highlights critical pathways required for neural tube closure.

Yoo-Jin Jiny Ha
Ashna Nisal
Joseph G. Gleeson
Research26 Mar 2025
Nature

Volume: 641, P: 419-426
Three-dimensional reconstruction of the fibres of sickle cell haemoglobin

Gene Dykes
Richard H. Crepeau
Stuart J. Edelstein
Research06 Apr 1978
Nature

Volume: 272, P: 506-510
The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue

Miriam Hirshberg
Richard W. Stockley
Martin R. Webb
Research01 Feb 1997
Nature Structural Biology

Volume: 4, P: 147-152
Maternal HIV-1 viral load and vertical transmission of infection: The Ariel Project for the prevention of HIV transmission from mother to infant

Yunzhen Cao
Paul Krogstad
Arthur J. Ammann
Research01 May 1997
Nature Medicine

Volume: 3, P: 549-552
Ionization states of the catalytic residues in HIV-1 protease

Ross Smith
Ian M. Brereton
Stephen B.H. Kent
Research01 Nov 1996
Nature Structural Biology

Volume: 3, P: 946-950

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