Despite the growing prevalence and high morbidity and mortality associated with calcific aortic stenosis, until recently little was known about the cellular mechanism of this condition. Recent studies have demonstrated that the pathophysiology of aortic valve disease and vascular atherosclerosis is similar. Here, Nalini Rajamannan, Robert Bonow and Shahbudin Rahimtoola discuss the etiology and mechanisms of calcific aortic stenosis, its diagnosis and future medical therapies in the context of recent developments.
- Nalini M Rajamannan
- Robert O Bonow
- Shahbudin H Rahimtoola
