Disruption of neocortical circuitry and architecture causes neurodevelopmental disorders. Here the authors find that migration and axon projection of upper layer neurons are dependent on Sema7A-Sema4D heterodimerization, and that insufficient transcription of Sema7A or incomplete glycosylation of Sema4D inhibit these processes.
- Paraskevi Bessa
- Andrew G. Newman
- Victor Tarabykin
