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Showing 1–7 of 7 results

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Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Implantation of a multielectrode paddle that allows personalized electrical stimulation to all regions of the spinal cord involved in leg and trunk movements rapidly restores motor function in patients with spinal cord injury with complete paralysis.

Andreas Rowald
Salif Komi
Grégoire Courtine
Research07 Feb 2022
Nature Medicine

Volume: 28, P: 260-271
Hypothalamic deep brain stimulation augments walking after spinal cord injury

Whole-brain anatomical and activity surveys identify the lateral hypothalamus as a key driver of recovery from spinal cord injury, leading to a deep brain stimulation therapy that augments the recovery of walking in humans.

Newton Cho
Jordan W. Squair
Grégoire Courtine
Research02 Dec 2024
Nature Medicine

Volume: 30, P: 3676-3686
A spinal cord neuroprosthesis for locomotor deficits due to Parkinson’s disease

A spinal cord neuroprosthesis targeting leg motor neurons in real time improves walking and reduces freezing of gait in non-human primate models and in one individual with advanced Parkinson’s disease.

Tomislav Milekovic
Eduardo Martin Moraud
G. Courtine
Research06 Nov 2023
Nature Medicine

Volume: 29, P: 2854-2865
Walking naturally after spinal cord injury using a brain–spine interface

A reliable digital bridge restored communication between the brain and spinal cord and enabled natural walking in a participant with spinal cord injury.

Henri Lorach
Andrea Galvez
Grégoire Courtine
ResearchOpen Access24 May 2023
Nature

Volume: 618, P: 126-133
The neurons that restore walking after paralysis

Transcriptomic analysis following epidural electrical stimulation of the lumbar spinal cord during neurorehabilitation in mice identifies a population of neurons that orchestrates the restoration of walking following paralysis.

Claudia Kathe
Michael A. Skinnider
Grégoire Courtine
ResearchOpen Access09 Nov 2022
Nature

Volume: 611, P: 540-547
Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

An epidural spinal cord stimulation system regulates blood pressure in the acute and chronic phases of spinal cord injury.

Jordan W. Squair
Matthieu Gautier
Aaron A. Phillips
Research27 Jan 2021
Nature

Volume: 590, P: 308-314
Targeted neurotechnology restores walking in humans with spinal cord injury

Spatially selective and temporally controlled stimulation of the spinal cord, together with rehabilitation, results in substantial restoration of locomotor function in humans with spinal cord injury.

Fabien B. Wagner
Jean-Baptiste Mignardot
Grégoire Courtine
Research31 Oct 2018
Nature

Volume: 563, P: 65-71