Nature Search

Far-red sensitivity of dragon fish

Julian C. Partridge
Ron H. Douglas
Research04 May 1995
Nature

Volume: 375, P: 21-22
RNF43 mutations predict response to anti-BRAF/EGFR combinatory therapies in BRAF^V600E metastatic colorectal cancer

The presence of inactivating mutations in RNF43, a negative regulator of WNT, in tumor cells predicts improved response rates and survival outcomes in patients with metastatic BRAF^V600E colorectal cancer treated with anti-BRAF/EGFR therapy.

Elena Elez
Javier Ros
Rodrigo A. Toledo
ResearchOpen Access12 Sept 2022
Nature Medicine

Volume: 28, P: 2162-2170
Mutations in the APC tumour suppressor gene cause chromosomal instability

Riccardo Fodde
Jeroen Kuipers
Hans Clevers
Research22 Mar 2001
Nature Cell Biology

Volume: 3, P: 433-438
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
LGR5 marks targetable tumor-initiating cells in mouse liver cancer

Cancer stem cells (CSCs) are thought to be the main drivers for disease progression and treatment resistance in liver cancer. This study identifies the LGR5+ compartment as an important CSC population, representing a viable therapeutic target for combating liver cancer.

Wanlu Cao
Meng Li
Qiuwei Pan
ResearchOpen Access23 Apr 2020
Nature Communications

Volume: 11, P: 1-16
Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor)

Raymond Poon
Ron Smits
Benjamin A Alman
Research12 Mar 2001
Oncogene

Volume: 20, P: 451-460
HOXA13 in etiology and oncogenic potential of Barrett’s esophagus

Barrett’s esophagus is a pro-oncogenic lesion in the proximal gastrointestinal tract, but with a distal colon-like morphology. Here the authors report that the distal HOX gene HOXA13 is expressed in Barrett’s esophagus and in single cells of the physiological esophagus, and may underlie the phenotypic aspects of metaplasia and increase proliferation.

Vincent T. Janmaat
Kateryna Nesteruk
Maikel P. Peppelenbosch
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-17
p53 mutations implicate sunlight in post-transplant skin cancer irrespective of human papillomarivus status

Jane M McGregor
Ron JM Berkhout
Tim Crook
Research02 Oct 1997
Oncogene

Volume: 15, P: 1737-1740
Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling

Menno F. Kielman
Maaret Rindapää
Riccardo Fodde
Research11 Nov 2002
Nature Genetics

Volume: 32, P: 594-605
Lack of dominant-negative activity for tumor-related ZNRF3 missense mutations at endogenous levels

Shanshan Li
Jiahui Niu
Ron Smits
ResearchOpen Access14 Dec 2024
Oncogene

Volume: 44, P: 805-819
Marfan-like habitus and familial adenomatous polyposis in two unrelated males: a significant association?

George Calin
Juul Wijnen
Riccardo Fodde
Research22 Jun 1999
European Journal of Human Genetics

Volume: 7, P: 609-614
APC, Signal transduction and genetic instability in colorectal cancer

Riccardo Fodde
Ron Smits
Hans Clevers
Reviews01 Oct 2001
Nature Reviews Cancer

Volume: 1, P: 55-67
Restriction of intestinal stem cell expansion and the regenerative response by YAP

YAP has previously been identified as an oncogene that promotes cell growth, but now it is shown to restrict stem cell expansion during regeneration in the mouse intestine, suggesting that it may function as a tumour suppressor in colon cancer.

Evan R. Barry
Teppei Morikawa
Fernando D. Camargo
Research25 Nov 2012
Nature

Volume: 493, P: 106-110
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

Human coronavirus-EMC (hCoV-EMC) is a new coronavirus that has killed around half of the few humans infected so far; this study now identifies DPP4 as the receptor that this virus uses to infect cells.

V. Stalin Raj
Huihui Mou
Bart L. Haagmans
Research13 Mar 2013
Nature

Volume: 495, P: 251-254
Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines

Wenhui Wang
Pengyu Liu
Ron Smits
ResearchOpen Access02 Apr 2021
Scientific Reports

Volume: 11, P: 1-13
Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers

Shan Li
Marla Lavrijsen
Ron Smits
Research26 Feb 2020
Oncogene

Volume: 39, P: 3458-3472
Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation

Tim Koopmans
Laura Hesse
Reinoud Gosens
ResearchOpen Access21 Apr 2020
Scientific Reports

Volume: 10, P: 1-14
Ovarian stimulation for IVF and risk of primary breast cancer in BRCA1/2 mutation carriers

Inge A. P. Derks-Smeets
Lieske H. Schrijver
Encarna B. Gómez García
ResearchOpen Access25 Jun 2018
British Journal of Cancer

Volume: 119, P: 357-363
Convergent Transcription of Interferon-stimulated Genes by TNF-α and IFN-α Augments Antiviral Activity against HCV and HEV

Wenshi Wang
Lei Xu
Qiuwei Pan
ResearchOpen Access06 May 2016
Scientific Reports

Volume: 6, P: 1-14
Response to: An immunohistochemical approach to detect oncogenic CTNNB1 mutations in primary neoplastic tissues

Hendrikus J. Dubbink
Marla Lavrijsen
Ron Smits
Correspondence30 Jan 2019
Laboratory Investigation

Volume: 99, P: 445-446
How to make a mesodiencephalic dopaminergic neuron

Understanding the mechanisms involved in the development of mesodiencephalic dopaminergic neurons might contribute to the success of cell-replacement strategies for disorders such as Parkinson's disease. Smidt and Burbach review the factors governing specification, migration, differentiation and maintenance of these neurons.

Marten P. Smidt
J. Peter H. Burbach
Reviews01 Jan 2007
Nature Reviews Neuroscience

Volume: 8, P: 21-32

Search

Far-red sensitivity of dragon fish

RNF43 mutations predict response to anti-BRAF/EGFR combinatory therapies in BRAF^V600E metastatic colorectal cancer

Mutations in the APC tumour suppressor gene cause chromosomal instability

Mapping the human genetic architecture of COVID-19

LGR5 marks targetable tumor-initiating cells in mouse liver cancer

Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor)

HOXA13 in etiology and oncogenic potential of Barrett’s esophagus

p53 mutations implicate sunlight in post-transplant skin cancer irrespective of human papillomarivus status

Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling

Lack of dominant-negative activity for tumor-related ZNRF3 missense mutations at endogenous levels

Marfan-like habitus and familial adenomatous polyposis in two unrelated males: a significant association?

APC, Signal transduction and genetic instability in colorectal cancer

Restriction of intestinal stem cell expansion and the regenerative response by YAP

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines

Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers

Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation

Ovarian stimulation for IVF and risk of primary breast cancer in BRCA1/2 mutation carriers

Convergent Transcription of Interferon-stimulated Genes by TNF-α and IFN-α Augments Antiviral Activity against HCV and HEV

Response to: An immunohistochemical approach to detect oncogenic CTNNB1 mutations in primary neoplastic tissues

How to make a mesodiencephalic dopaminergic neuron

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