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Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca²⁺ channel activators

Selective inhibitors of the L-type Ca²⁺ channel Cav1.3 are being developed as neuroprotective drugs. Here, Ortner et al. assess the pharmacological properties of a recently reported, selective Cav1.3 blocker and show that this agent is a Ca²⁺channel activator.

Nadine J. Ortner
Gabriella Bock
Jörg Striessnig
ResearchOpen Access19 Jun 2014
Nature Communications

Volume: 5, P: 1-10
A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma

Stefan Salcher
Gilles Spoden
Petra Obexer
ResearchOpen Access07 Oct 2019
Oncogene

Volume: 39, P: 1080-1097

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Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators

A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma

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Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca²⁺ channel activators