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Showing 1–14 of 14 results
Advanced filters: Author: Rosandra N Kaplan Clear advanced filters

    • Rosandra N. Kaplan
    • Rebecca D. Riba
    • J. Wels
    Research
    Nature
    Volume: 461, P: E5

  • Adrenocortical carcinoma (ACC) has limited treatment options and few tumor-specific targets. Here the authors report that the Notch ligand DLK1 is highly expressed in ACC acting as a regulator of tumor cell plasticity and chemoresistance, and that DLK1 can be targeted with an antibody drug conjugate.

    • Nai-Yun Sun
    • Suresh Kumar
    • Nitin Roper
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • In a phase 2 trial of adults with neurofibromatosis type 1 and inoperable/growing plexiform neurofibromas, treatment with the MEK inhibitor selumetinib resulted in an objective response rate of 63.6% and improvement in other patient outcomes, with additional biopsy-based data providing further information on drug activity.

    • Andrea M. Gross
    • Geraldine O’Sullivan Coyne
    • Brigitte C. Widemann
    Research
    Nature Medicine
    Volume: 31, P: 105-115

  • Biomarkers predictive of response to T cell therapy remain to be better defined. This study identifies potential predictive and pharmacodynamic markers of response to NY-ESO-1 T-cell therapy in a solid tumor that may inform lymphodepletion, cell dose, and strategies to enhance anticancer efficacy.

    • Alexandra Gyurdieva
    • Stefan Zajic
    • Ioanna Eleftheriadou
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Kaplan and colleagues discuss adaptations in the bone environment in the context of cancer, reflect on advanced technologies to study these bone niches and summarize how a remodeled bone marrow milieu can prime other sites for metastasis.

    • Kailey N. Jackett
    • Alice T. Browne
    • Rosandra N. Kaplan
    Reviews
    Nature Cancer
    Volume: 5, P: 1800-1814

  • Exosomes can transfer proteins and nucleic acids from one cell to another, altering the phenotype of the recipient cell. In the case of cancer, tumor-derived exosomes have been shown to promote tumor cell proliferation. Now, in a mouse model of melanoma, Peinado et al. report that exosomes derived from highly metastatic tumor cells can influence bone marrow cells, resulting in increased recruitment of provasculogenic bone marrow progenitors to sites of metastasis, increased primary tumor growth and metastatic spread.

    • Héctor Peinado
    • Maša Alečković
    • David Lyden
    Research
    Nature Medicine
    Volume: 18, P: 883-891

  • Factors secreted by metastatic a primary tumors induce an early phenotypic switch in perivascular cells at distant pre-metastatic niches. By using sophisticated lineage-tracing mouse models, the authors demonstrate that enhanced KLF4 expression in these cells increases their ability to proliferate and migrate away from the vasculature, and augments fibronectin deposition, which contributes to metastatic growth. These findings increase the mechanistic understanding of the metastatic process and uncover a role for perivascular plasticity that could be targeted to prevent metastasis.

    • Meera Murgai
    • Wei Ju
    • Rosandra N Kaplan
    Research
    Nature Medicine
    Volume: 23, P: 1176-1190

  • In this Roadmap, Boire et al. consider the immediate causes of mortality in patients with cancer, a topic not often considered in either preclinical or clinical research, and provide recommendations for how we can stimulate research to advance our mechanistic understanding of these causes with a long-term view to improving the quality of life for patients with late-stage cancer.

    • Adrienne Boire
    • Katy Burke
    • Erik Sahai
    Reviews
    Nature Reviews Cancer
    Volume: 24, P: 578-589

  • The pre-metastatic niche is a complex microenvironment formed by the influence of tumor-derived factors on stromal and immune cells at distant sites of disseminated tumor-cell colonization. Signaling through the kinase p38α and regulation of the type I interferon receptor are now linked to formation of the pre-metastatic niche.

    • Sabina Kaczanowska
    • Rosandra N. Kaplan
    News & Views
    Nature Cancer
    Volume: 1, P: 577-579

  • Tumour progression is promoted by the generation of an immunosuppressive macroenvironment. Here, the authors demonstrate that the Inhibitor of Differentiation 1 promotes the switch from dendritic cell differentiation towards myeloid-derived suppressor cell expansion during tumour progression.

    • Marianna Papaspyridonos
    • Irina Matei
    • David Lyden
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • This Review summarizes the natural progression of pre-metastatic niche formation and evolution, highlighting recent advances and future hurdles.

    • Héctor Peinado
    • Haiying Zhang
    • David Lyden
    Reviews
    Nature Reviews Cancer
    Volume: 17, P: 302-317