Nature Search

Dark-based optical sectioning assists background removal in fluorescence microscopy

The Dark sectioning algorithm removes the background and provides single-frame optical sectioning in fluorescence microscopy. It offers improved quantitative analysis and deep-tissue segmentation accuracy and is compatible to diverse modalities.

Ruijie Cao
Yaning Li
Peng Xi
Research12 May 2025
Nature Methods

Volume: 22, P: 1299-1310
Inorganic perovskite/organic tandem solar cells with 25.1% certified efficiency via bottom contact modulation

The performance of inorganic, wide-bandgap perovskite solar cells is hindered by unsuitable electron transport layers. Han et al. design an acidic magnesium-doped tin oxide quantum dot layer, improving efficiency and stability in single-junction and tandem cells.

Yu Han
Jiehao Fu
Gang Li
Research13 Mar 2025
Nature Energy

Volume: 10, P: 513-525
Therapeutic targeting of the mevalonate–geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer

Ji and colleagues demonstrate that metabolic reprogramming in SCLC underlies chemotherapy resistance, resulting in an actionable dependency on the mevalonate pathway in tumor cells, which can be targeted using statins to revert chemoresistance.

Chenchen Guo
Ruijie Wan
Hongbin Ji
Research21 Apr 2022
Nature Cancer

Volume: 3, P: 614-628
Open-3DSIM: an open-source three-dimensional structured illumination microscopy reconstruction platform

Open-3DSIM is a versatile open-source software for high-fidelity reconstruction of three-dimensional structured illumination microscopy data (with polarization). It is available in three convenient forms for user-friendly and customizable applications.

Ruijie Cao
Yaning Li
Peng Xi
ResearchOpen Access20 Jul 2023
Nature Methods

Volume: 20, P: 1183-1186
Author Correction: Open-3DSIM: an open-source three-dimensional structured illumination microscopy reconstruction platform

Ruijie Cao
Yaning Li
Peng Xi
Amendments and CorrectionsOpen Access24 Aug 2023
Nature Methods

Volume: 20, P: 1437
Rhodium-catalyzed enantioselective and diastereodivergent access to diaxially chiral heterocycles

Molecules with axial chirality are of intense focus to the synthetic organic community, but the axes most commonly explored are carbon–carbon and carbon–heteroatom. Here the authors report the syntheses of diaxially chiral biaryls containing N-N and C-N/C-C axes, achieved via rhodium catalysis.

Yishou Wang
Xiaohan Zhu
Xingwei Li
ResearchOpen Access03 Aug 2023
Nature Communications

Volume: 14, P: 1-12
Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT

CesT is a type III secretion system chaperone that interacts with the post-transcriptional regulator CsrA, which is important for the modulation of post-attachment signaling in enteropathogenic and enterohemorrhagic Escherichia coli. Here the authors present the structure of the CsrA/CesT complex and propose a mechanism for CsrA-modulation by CesT.

Fei Ye
Fanli Yang
Guangwen Lu
ResearchOpen Access22 Mar 2018
Nature Communications

Volume: 9, P: 1-11
Structural insights into DNA cleavage activation of CRISPR-Cas9 system

CRISPR-Cas9 is widely used for genome engineering but structural data for the DNA cleavage step are still incomplete. Here, the authors present the cryo-EM structure of a ternary Cas9-sgRNA-target DNA complex, perform MD simulations and discuss implications for the Cas9 DNA cleavage mechanism.

Cong Huai
Gan Li
Qiang Huang
ResearchOpen Access09 Nov 2017
Nature Communications

Volume: 8, P: 1-9
Robotic wireless capsule endoscopy: recent advances and upcoming technologies

future requirements for intelligent wireless capsule endoscopy, providing a comparative evaluation of various methods’ merits and disadvantages, and highlighting recent developments in six technologies.

Qing Cao
Runyi Deng
Dong Han
ReviewsOpen Access30 May 2024
Nature Communications

Volume: 15, P: 1-21
RNF166 promotes colorectal cancer progression by recognizing and destabilizing poly-ADP-ribosylated angiomotins

Yun Li
Xiangqian Zhang
Yongheng Chen
ResearchOpen Access13 Mar 2024
Cell Death & Disease

Volume: 15, P: 1-13
2 μm emission properties and nonresonant energy transfer of Er³⁺ and Ho³⁺ codoped silicate glasses

Ruijie Cao
Yu Lu
Junjie Zhang
ResearchOpen Access30 Nov 2016
Scientific Reports

Volume: 6, P: 1-11
The molybdenum cycle in the oxygenated Neoproterozoic ocean was coupled to manganese carbonate mineralization

The periodic contraction of euxinic zones in the Neoproterozoic Ocean shaped the mineralization of manganese and the oceanic molybdenum cycle, according to iron, molybdenum and nitrogen geochemical data from back shales and carbonates in the upper Doushantuo Formation, South China.

Bin Zhang
Jian Cao
Kurt O. Konhauser
ResearchOpen Access20 Nov 2024
Communications Earth & Environment

Volume: 5, P: 1-10
Comprehensive rehabilitation with integrative medicine for subacute stroke: A multicenter randomized controlled trial

Jianqiao Fang
Lifang Chen
Shouyu Xu
ResearchOpen Access13 May 2016
Scientific Reports

Volume: 6, P: 1-11
Sestrin2-mediated disassembly of stress granules dampens aerobic glycolysis to overcome glucose starvation

Mingyue Li
Rick Francis Thorne
Lianxin Liu
ResearchOpen Access14 Apr 2023
Cell Death Discovery

Volume: 9, P: 1-14
Strenuous exercise-tolerance stretchable dry electrodes for continuous multi-channel electrophysiological monitoring

Ruijie Xie
Qingsong Li
Zhiyuan Liu
ResearchOpen Access18 Aug 2022
npj Flexible Electronics

Volume: 6, P: 1-9
Superresolution structured illumination microscopy reconstruction algorithms: a review

Xin Chen
Suyi Zhong
Peng Xi
ReviewsOpen Access12 Jul 2023
Light: Science & Applications

Volume: 12, P: 1-34

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