Aging is a risk factor of cancer, but how an aged immune system transforms the tumor microenvironment (TME) is unclear. By leveraging scRNA-seq analysis in a mouse model of metastatic melanoma, here the authors show that a γδ17-dependent increase in neutrophils inhibits the proliferation and stemness of CD8+ T cells, thereby promoting tumor metastasis.
- Runping Duan
- Loujing Jiang
- Wenru Su
