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ADSL promotes autophagy and tumor growth through fumarate-mediated Beclin1 dimethylation

Protein kinase R-like endoplasmic reticulum kinase-phosphorylated adenylosuccinate lyase (ADSL) binds to Beclin1 upon lipid deprivation. ADSL-produced fumarate increases Beclin1 K117 dimethylation by inhibiting lysine demethylase 8 activity, resulting in disrupted binding of BCL-2 to Beclin1, enhanced autophagy and liver tumor growth.

Lei Wang
Runze Shi
Daqian Xu
Research29 Jan 2025
Nature Chemical Biology

Volume: 21, P: 894-905
RETRACTED ARTICLE: Long non-coding RNA DIO3OS binds to microRNA-130b to restore radiosensitivity in esophageal squamous cell carcinoma by upregulating PAX9

Junqi Liu
Runze Zhou
Di Zhao
Research28 Jun 2021
Cancer Gene Therapy

Volume: 29, P: 870
High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

Several engineered Cas13 variants achieve targeted RNA degradation with minimal collateral effects.

Huawei Tong
Jia Huang
Hui Yang
Research11 Aug 2022
Nature Biotechnology

Volume: 41, P: 108-119
Genome-wide association studies provide insights into the genetic determination of fruit traits of pear

Studies of fruit quality traits in pears are lagging behind the other major fruit trees. Here, the authors conduct GWAS of fruit quality and phenological traits in a panel of 312 sand pear accessions using SNPs called from resequencing data, and reveal the involvement of a lignin formation-related protein in regulating stone cell development.

Ming-Yue Zhang
Cheng Xue
Jun Wu
ResearchOpen Access18 Feb 2021
Nature Communications

Volume: 12, P: 1-10
Microplastic fragmentation by rotifers in aquatic ecosystems contributes to global nanoplastic pollution

Here the authors show that the trophi or jaws of the chitinous masticatory apparatus of marine and freshwater zooplankton rotifers can grind microplastics, independent of polymer composition, and generate particulate nanoplastics, which may accelerate the nanoplastic flux in global surface waters.

Jian Zhao
Ruyi Lan
Baoshan Xing
Research09 Nov 2023
Nature Nanotechnology

Volume: 19, P: 406-414
Investigation and application of data balancing and combined discriminant model in rock burst severity prediction

Shaohong Yan
Runze Liu
Shuai Wang
ResearchOpen Access29 Nov 2024
Scientific Reports

Volume: 14, P: 1-24
Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations

Wang et al. developed a transformer base editor system in which the enzyme activity of the base editor is turned on only at the on-target site, therefore minimizing genome-wide and transcriptome-wide off-target mutations.

Lijie Wang
Wei Xue
Jia Chen
Research10 May 2021
Nature Cell Biology

Volume: 23, P: 552-563
Death receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis

Jianbo Liu
Kaixuan Liu
Bing Xue
ResearchOpen Access10 Jan 2024
Cell Death & Disease

Volume: 15, P: 1-15
Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome

J. Yuyang Lu
Lei Chang
Xiaohua Shen
ResearchOpen Access29 Jan 2021
Cell Research

Volume: 31, P: 613-630
Activation of G protein coupled estrogen receptor prevents chemotherapy-induced intestinal mucositis by inhibiting the DNA damage in crypt cell in an extracellular signal-regulated kinase 1- and 2- dependent manner

Guanyu Chen
Honghui Zeng
Bing Xue
ResearchOpen Access30 Oct 2021
Cell Death & Disease

Volume: 12, P: 1-15

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ADSL promotes autophagy and tumor growth through fumarate-mediated Beclin1 dimethylation

RETRACTED ARTICLE: Long non-coding RNA DIO3OS binds to microRNA-130b to restore radiosensitivity in esophageal squamous cell carcinoma by upregulating PAX9

High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

Genome-wide association studies provide insights into the genetic determination of fruit traits of pear

Microplastic fragmentation by rotifers in aquatic ecosystems contributes to global nanoplastic pollution

Investigation and application of data balancing and combined discriminant model in rock burst severity prediction

Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations

Death receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis

Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome

Activation of G protein coupled estrogen receptor prevents chemotherapy-induced intestinal mucositis by inhibiting the DNA damage in crypt cell in an extracellular signal-regulated kinase 1- and 2- dependent manner

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